Protein O-Mannosyltransferases Associate with the Translocon to Modify Translocating Polypeptide Chains

Autor: Johannes Hutzler, Markus Aebi, Martin Loibl, Lina Wunderle, Benjamin L. Schulz, Sabine Strahl

Publikováno v: Journal of Biological Chemistry. 289:8599-8611

O-Mannosylation and N-glycosylation are essential protein modifications that are initiated in the endoplasmic reticulum (ER). Protein translocation across the ER membrane and N-glycosylation are highly coordinated processes that take place at the tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9c73f75adcbf6583a2298a630de7968
https://doi.org/10.1074/jbc.m113.543116

On the mode of action of the herbicides cinmethylin and 5-benzyloxymethyl-1, 2-isoxazolines: putative inhibitors of plant tyrosine aminotransferase

Autor: Thomas Ehrhardt, Johannes Hutzler, Ralf Looser, Klaus Grossmann, Stefan Tresch, Nicole Christiansen

Publikováno v: Pest Management Science. 68:482-492

BACKGROUND: The mode of action of the grass herbicides cinmethylin and 5-benzyloxymethyl-1,2-isoxazolines substituted with methylthiophene (methiozolin) or pyridine (ISO1, ISO2) was investigated. RESULTS: Physiological profiling using a series of bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baca9819376eb86c1f31bbaa75af90db
https://doi.org/10.1002/ps.2319

Functional and genomic analyses of blocked protein O-mannosylation in baker's yeast

Autor: Pedro Botías, Johannes Hutzler, Andrea Schott, Jesús García-Cantalejo, Enrico Ragni, Heidi Piberger, Sabine Strahl, Ana Belen Sanz, Javier Arroyo, Clara Bermejo

Publikováno v: Molecular Microbiology. 79:1529-1546

Summary O-mannosylation is a crucial protein modification in eukaryotes that is initiated by the essential family of protein O-mannosyltransferases (PMTs). Here we demonstrate that in the model yeast Saccharomyces cerevisiae rhodanine-3-acetic acid d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08d363ea36db10e4c81a2c4b83734d1b
https://doi.org/10.1111/j.1365-2958.2011.07537.x

Physionomics and metabolomics-two key approaches in herbicidal mode of action discovery

Autor: Klaus Grossmann, Stefan Tresch, Ralf Looser, Johannes Hutzler, Thomas Ehrhardt, Nicole Christiansen, Stephan Pollmann

Publikováno v: Pest management science. 68(4)

BACKGROUND: For novel herbicides identified in greenhouse screens, efficient research is important to discover and chemically optimise new leads with new modes of action (MoAs). RESULTS: The metabolic and physiological response pattern to a herbicide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06cff79061d460d7c651dac7286361e8
https://pubmed.ncbi.nlm.nih.gov/22076706

Effects of the aglycone of ascaulitoxin on amino acid metabolism in Lemna paucicostata

Autor: Maurizio Vurro, Antonio Evidente, Michele Fiore, Ralf Looser, Stephen O. Duke, Nicole Christiansen, Johannes Hutzler, Agnes M. Rimando, Klaus Grossmann, Franck E. Dayan

Publikováno v: Pesticide biochemistry and physiology 100 (2011): 41–50. doi:10.1016/j.pestbp.2011.02.002
info:cnr-pdr/source/autori:Duke S.O., Evidente A., Fiore M., Rimando A.M., Dayan F.E., Vurro M., Christiansen N., Looser R., Hutzler J., Grossmann K./titolo:Effects of the aglycone of ascaulitoxin on amino acid metabolism in Lemna paucicostata./doi:10.1016%2Fj.pestbp.2011.02.002/rivista:Pesticide biochemistry and physiology/anno:2011/pagina_da:41/pagina_a:50/intervallo_pagine:41–50/volume:100

Ascaulitoxin and its aglycone (2,4,7-triamino-5-hydroxyoctanoic acid, CAS 212268-55-8) are potent phytotoxins produced by Ascochyta caulina , a plant pathogen being developed for biocontrol of weeds. The mode of action of this non-protein amino acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d32ff7da322d1c2211905f1922083d2