Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Johannes Hettich"'
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-30 (2022)
Abstract Background The temporal progression of many fundamental processes in cells and organisms, including homeostasis, differentiation and development, are governed by gene regulatory networks (GRNs). GRNs balance fluctuations in the output of the
Externí odkaz:
https://doaj.org/article/976e1273fb234b509ff9034a557e531a
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Imaging, tracking and analyzing individual biomolecules in living systems is a powerful technology to obtain quantitative kinetic and spatial information such as reaction rates, diffusion coefficients and localization maps. Common tracking t
Externí odkaz:
https://doaj.org/article/e322431a14bd43cda465d8be9e63666c
Autor:
Oliver Kuchler, Jule Gerlach, Thomas Vomhof, Johannes Hettich, Julia Steinmetz, J. Christof M. Gebhardt, Jens Michaelis, Bernd Knöll
Publikováno v:
Open Biology, Vol 12, Iss 5 (2022)
In cells, proteins encoded by the same gene do not all behave uniformly but engage in functional subpopulations induced by spatial or temporal segregation. While conventional microscopy has limitations in revealing such spatial and temporal diversity
Externí odkaz:
https://doaj.org/article/fbbd17f4d42c4c349cfa4af586970ff3
Autor:
null Oliver Kuchler, null Jule Gerlach, null Thomas Vomhof, null Johannes Hettich, null Julia Steinmetz, null J. Christof M. Gebhardt, null Jens Michaelis, null Bernd Knöll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::854d0896f0c992b509fc19068d655b93
https://doi.org/10.1098/rsob.210383/v2/response1
https://doi.org/10.1098/rsob.210383/v2/response1
Publikováno v:
bioRxiv
Transcription is a vital process activated by transcription factor (TF) binding. The active gene releases a burst of transcripts before turning inactive again. While the basic course of transcription is well understood, it is unclear how binding of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4b69e6477343f5e43ac63e55b47d6b
https://doi.org/10.1101/2020.11.26.400069
https://doi.org/10.1101/2020.11.26.400069
Publikováno v:
bioRxiv
Imaging, tracking and analyzing individual biomolecules in living systems is a powerful technology to obtain quantitative kinetic and spatial information such as reaction rates, diffusion coefficients and localization maps. Common tracking tools ofte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db474c07dc3461a36eb1f66130276b61
https://doi.org/10.1101/2020.11.25.398271
https://doi.org/10.1101/2020.11.25.398271
Autor:
Johannes Hettich, Matthias Reisser, J. Christof M. Gebhardt, Timo Kuhn, Andreas Große-Berkenbusch, Achim P. Popp
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Actions of molecular species, for example binding of transcription factors to chromatin, may comprise several superimposed reaction pathways. The number and the rate constants of such superimposed reactions can in principle be resolved by inverse Lap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e8869c35c6db983b44583f18e2e15e3
https://doi.org/10.1038/s41598-020-58634-y
https://doi.org/10.1038/s41598-020-58634-y
Autor:
J.C.M. Gebhardt, Johannes Hettich
Publikováno v:
Journal of Theoretical Biology
Highlights • Transcription factor target site search time calculated using dissociation rates. • Transcription factors are optimized for fast target site search. • Transcription factors are not optimized for high target site occupation. • Dim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2096702274494ce25dcd0b6c6ea8de1
https://doi.org/10.1016/j.jtbi.2018.05.037
https://doi.org/10.1016/j.jtbi.2018.05.037
Autor:
Gebhardt Jcm, Johannes Hettich
BackgroundThe temporal progression of many fundamental processes in cells and organisms, including homeostasis, differentiation and development, are governed by gene regulatory networks (GRNs). GRNs balance fluctuations in the output of their genes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53f21672cc97e8617fd504249f23bd1a
https://doi.org/10.1101/872374
https://doi.org/10.1101/872374
Actions of molecular species, for example binding of transcription factors to chromatin, are intrinsically stochastic and may comprise several mutually exclusive pathways. Inverse Laplace transformation in principle resolves the rate constants and fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75cc7728d524e1160c3666ec1e1eeb7