Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Johannes Herkel"'
Autor:
Daria Krzikalla, Alena Laschtowitz, Lisa Leypoldt, Cornelia Gottwick, Pia Averhoff, Sören Weidemann, Ansgar W. Lohse, Samuel Huber, Christoph Schramm, Dorothee Schwinge, Johannes Herkel, Antonella Carambia
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 1, Pp 79-91 (2024)
Background & Aims: The liver has a distinct capacity to induce immune tolerance to hepatic antigens. Although liver tolerance can be advantageous for preventing autoimmune and inflammatory diseases, it also can be detrimental by preventing immune sur
Externí odkaz:
https://doaj.org/article/5bdb57d96fae45dab3880fcdea472873
Autor:
Max Preti, Lena Schlott, David Lübbering, Daria Krzikalla, Anna-Lena Müller, Fenja A. Schuran, Tobias Poch, Miriam Schakat, Sören Weidemann, Ansgar W. Lohse, Christina Weiler-Normann, Marcial Sebode, Dorothee Schwinge, Christoph Schramm, Antonella Carambia, Johannes Herkel
Publikováno v:
JCI Insight, Vol 6, Iss 6 (2021)
The liver is an immune-privileged organ that can deactivate autoreactive T cells. Yet in autoimmune hepatitis (AIH), autoreactive T cells can defy hepatic control and attack the liver. To elucidate how tolerance to self-antigens is lost during AIH pa
Externí odkaz:
https://doaj.org/article/562c142691284b8baadaf1974c991cea
Autor:
Marcial Sebode, Jennifer Wigger, Pamela Filpe, Lutz Fischer, Sören Weidemann, Till Krech, Christina Weiler-Normann, Moritz Peiseler, Johannes Hartl, Eva Tolosa, Johannes Herkel, Christoph Schramm, Ansgar W. Lohse, Philomena Arrenberg
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Background: Natural Killer T (NKT) cells are CD1d-restricted innate-like T cells that can rapidly release stored cytokines upon recognition of lipid antigens. In mice, type I NKT cells seem to promote liver inflammation, whereas type II NKT cells see
Externí odkaz:
https://doaj.org/article/54c5a1a0385d42709a8bec56900a540d
Autor:
May Brundert, Joerg Heeren, Martin Merkel, Antonella Carambia, Johannes Herkel, Peter Groitl, Thomas Dobner, Rajasekhar Ramakrishnan, Kathryn J. Moore, Franz Rinninger
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 4, Pp 745-758 (2011)
The mechanisms of HDL-mediated cholesterol transport from peripheral tissues to the liver are incompletely defined. Here the function of scavenger receptor cluster of differentiation 36 (CD36) for HDL uptake by the liver was investigated. CD36 knocko
Externí odkaz:
https://doaj.org/article/c313385d40ab41eebf6bec15f5919260
Autor:
Tanja Trautmann, Jan-Hendrik Kozik, Antonella Carambia, Kirsten Richter, Timo Lischke, Dorothee Schwinge, Hans-Willi Mittrücker, Ansgar W Lohse, Annette Oxenius, Christiane Wiegard, Johannes Herkel
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86348 (2014)
Cytotoxic CD8+ T cells are essential for the control of viral liver infections, such as those caused by HBV or HCV. It is not entirely clear whether CD4+ T-cell help is necessary for establishing anti-viral CD8+ T cell responses that successfully con
Externí odkaz:
https://doaj.org/article/df0c44a94aae4620b2011e6b311ee2af
Autor:
Samuel Huber, Jörg Schrader, Gerhard Fritz, Katrin Presser, Steffen Schmitt, Ari Waisman, Stefan Lüth, Manfred Blessing, Johannes Herkel, Christoph Schramm
Publikováno v:
PLoS ONE, Vol 3, Iss 10, p e3302 (2008)
CD4+CD25+ regulatory T cells (Treg) are important mediators of immune tolerance. A subset of Treg can be generated in the periphery by TGF-beta dependent conversion of conventional CD4+CD25- T cells into induced Treg (iTreg). In chronic viral infecti
Externí odkaz:
https://doaj.org/article/cea96cd8600041a5aab4cd67cfc71bad
Publikováno v:
Seminars in Immunopathology. 44:475-484
Autoimmune diseases develop when the adaptive immune system attacks the body’s own antigens leading to tissue damage. At least 80 different conditions are believed to have an autoimmune aetiology, including rheumatoid arthritis, type I diabetes, mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04aa6dae12e137a5af1d0ece88a3f6cc
https://doi.org/10.1007/s00281-022-00942-8
https://doi.org/10.1007/s00281-022-00942-8
Autor:
David Lübbering, Max Preti, Lena Schlott, Christoph Schultheiß, Sören Weidemann, AnsgarW. Lohse, Mascha Binder, Antonella Carambia, Johannes Herkel
Publikováno v:
39. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c81e8da1a4d6823fe7425914b466c852
https://doi.org/10.1055/s-0042-1760071
https://doi.org/10.1055/s-0042-1760071
Autor:
Tobias Poch, Johannes Herkel, Luisa Marie Müller, Romina Fiorotto, Antonella Carambia, Till Krech, Lutz Fischer, Dorothee Schwinge, Mario Strazzabosco, S Stein, Lara Henze, Jun Li, M Reich, Nicola Gagliani, M Preti, Christoph Schramm, Verena Keitel, Jonas Wagner, Fenja Amrei Schuran
Publikováno v:
J Hepatol
Background & Aims IL-17A-producing T cells are present in autoimmune cholestatic liver diseases; however, little is known about the contribution of IL-17 to periductal immune responses. Herein, we investigated the role of IL-17 produced by antigen-sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72ec9bbf95fed1e7626bf78224b6fb5
https://doi.org/10.1016/j.jhep.2020.10.035
https://doi.org/10.1016/j.jhep.2020.10.035
Autor:
Christina Weiler-Normann, Ansgar W. Lohse, Anna Woestemeier, Claudia S Bovensiepen, Miriam Schakat, Johannes Herkel, Christoph Schramm, Roman Zenouzi, Moritz Peiseler, Johannes Hartl, Marcial Sebode, Jun Li, Lara Henze
Publikováno v:
The Journal of Immunology. 203:3148-3156
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease that is believed to be driven by a CD4+ T cell response to liver Ags. However, the pathogenic function of CD4+ effector T cells in AIH is not fully understood. To characterize liver-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644333d1664f511faba9acef96674a4b
https://doi.org/10.4049/jimmunol.1900124
https://doi.org/10.4049/jimmunol.1900124