Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Johannes H. Hegemann"'
Autor:
Fabienne Kocher, Violetta Applegate, Jens Reiners, Astrid Port, Dominik Spona, Sebastian Hänsch, Amin Mirzaiebadizi, Mohammad Reza Ahmadian, Sander H. J. Smits, Johannes H. Hegemann, Katja Mölleken
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract To enter epithelial cells, the obligate intracellular pathogen Chlamydia pneumoniae secretes early effector proteins, which bind to and modulate the host-cell’s plasma membrane and recruit several pivotal endocytic host proteins. Here, we
Externí odkaz:
https://doaj.org/article/2a73c453c2a44f94808310ce7e6a6a97
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Uptake of obligate intracellular bacterial pathogens into mammalian epithelial cells is critically dependent on modulation of the host’s endocytic machinery. It is an open question how the invading pathogens generate a membrane-bound vesic
Externí odkaz:
https://doaj.org/article/a091387f29e2433899ea6bb654af7fe0
Autor:
Isabelle N. Erenburg, Sebastian Hänsch, Feby M. Chacko, Anna Hamacher, Sebastian Wintgens, Fabian Stuhldreier, Gereon Poschmann, Olivia Spitz, Kai Stühler, Sebastian Wesselborg, Johannes H. Hegemann, Sander H. J. Smits, Stefanie Weidtkamp-Peters, Lutz Schmitt
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Many proteins of the Repeats in Toxins (RTX) protein family are toxins of Gram-negative pathogens including hemolysin A (HlyA) of uropathogenic E. coli. RTX proteins are secreted via Type I secretion systems (T1SS) and adopt their native con
Externí odkaz:
https://doaj.org/article/37bf837447c345038a8921ad00a7000f
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Chlamydia psittaci (C. psittaci) is an obligate intracellular, gram-negative bacterium, and mainly causes systemic disease in psittacine birds, domestic poultry, and wild fowl. The pathogen is threating to human beings due to closely contacted to emp
Externí odkaz:
https://doaj.org/article/22087df194bb4e37a939e1eb291aed11
Autor:
Alison Favaroni, Johannes H. Hegemann
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Chlamydiae are Gram-negative, obligate intracellular bacteria, which infect animals and humans. Adhesion to host cells, the first step in the infection process, is mediated by polymorphic membrane proteins (Pmps). Pmps constitute the largest chlamydi
Externí odkaz:
https://doaj.org/article/ecec97e666df4de0ac456dae972d402b
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
The Chlamydia pneumoniae adhesin LIPP plays a role in host cell entry and infection. Here, the authors find that LIPP binds to the host plasma membrane and mediates phosphatidylserine translocation, enhancing pathogen internalization without inductio
Externí odkaz:
https://doaj.org/article/1643ac98c9124ac98254b991fe40a290
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Chlamydia psittaci is the etiological agent of chlamydiosis in birds and can be transmitted to humans, causing severe systemic disease. C. psittaci infects a broad range of hosts; strains are isolated not only from birds but also from mammals, where
Externí odkaz:
https://doaj.org/article/b05027af6c2c4ffa8610a55f32948be7
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Chlamydia pneumoniae is an obligate intracellular pathogen that causes diseases of the upper and lower respiratory tract and is linked to a number of severe and chronic conditions. Here, we describe a large, C. pneumoniae-specific cluster of 13 genes
Externí odkaz:
https://doaj.org/article/421d72bc50fc45e1b936b9705fdbb4eb
Autor:
Christian Lanfermann, Sebastian Wintgens, Thomas Ebensen, Martin Kohn, Robert Laudeley, Kai Schulze, Claudia Rheinheimer, Johannes H. Hegemann, Carlos Alberto Guzmán, Andreas Klos
Publikováno v:
Vaccines, Vol 9, Iss 6, p 609 (2021)
Chlamydia trachomatis is the most frequent sexually-transmitted disease-causing bacterium. Urogenital serovars of this intracellular pathogen lead to urethritis and cervicitis. Ascending infections result in pelvic inflammatory disease, salpingitis,
Externí odkaz:
https://doaj.org/article/58475f704f05430bbf6420ed8f041d22
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)
Pathogenic Chlamydia species force entry into human cells via specific adhesin-receptor interactions and subsequently secrete effector proteins into the host cytoplasm, which in turn modulate host-cell processes to promote infection. One such effecto
Externí odkaz:
https://doaj.org/article/bbab595677ba40dda25b47d7fd433864