Výsledky vyhledávání - "Johannes H Proost"

Akademický článek

Vancomycin pharmacokinetic model development in patients on intermittent online hemodiafiltration.

Autor: Niels Westra, Johannes H Proost, Casper F M Franssen, Erik B Wilms, Marjolijn van Buren, Daan J Touw

Publikováno v: PLoS ONE, Vol 14, Iss 5, p e0216801 (2019)

BackgroundVancomycin is frequently used in hemodialysis (HD) and in hemodiafiltration (HDF) patients and is usually administered in the last 30 or 60 minutes of a dialysis session. Vancomycin pharmacokinetics are not well described in HDF patients. T

Externí odkaz: https://doaj.org/article/75862af80f3840deab874975b766f807

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Akademický článek

Pharmacokinetic modeling of gentamicin in treatment of infective endocarditis: Model development and validation of existing models.

Autor: Anna Gomes, Lars van der Wijk, Johannes H Proost, Bhanu Sinha, Daan J Touw

Publikováno v: PLoS ONE, Vol 12, Iss 5, p e0177324 (2017)

Gentamicin shows large variations in half-life and volume of distribution (Vd) within and between individuals. Thus, monitoring and accurately predicting serum levels are required to optimize effectiveness and minimize toxicity. Currently, two popula

Externí odkaz: https://doaj.org/article/0a7fd192afe7484fa0723f0930fd594c

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Comparison of haemodynamic- and electroencephalographic-monitored effects evoked by four combinations of effect-site concentrations of propofol and remifentanil, yielding a predicted tolerance to laryngoscopy of 90%

Autor: Michel Struys, Johannes H. Proost, Hugo Vereecke, K. van Amsterdam, Alain Kalmar, Sascha Meier, Allart M. Venema, Anthony Absalom, Thomas Scheeren, Laura N. Hannivoort, J. P. van den Berg

Publikováno v: Journal of clinical monitoring and computing, 35. SPRINGER HEIDELBERG
JOURNAL OF CLINICAL MONITORING AND COMPUTING
Journal of Clinical Monitoring and Computing

This prospective study evaluates haemodynamic and electroencephalographic effects observed when administering four combinations of effect-site concentrations of propofol (CePROP) and remifentanil (CeREMI), all yielding a single predicted probability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50679a92c1d4005e4cfd41680f5b329
https://doi.org/10.1007/s10877-020-00540-9

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Population Pharmacodynamic Modeling Using the Sigmoid Emax Model: Influence of Inter-individual Variability on the Steepness of the Concentration–Effect Relationship. a Simulation Study

Autor: Douglas J. Eleveld, Michel Struys, Johannes H. Proost

Publikováno v: The AAPS Journal
Aaps journal, 23(1):10. SPRINGER
AAPS JOURNAL

The relationship between the concentration of a drug and its pharmacological effect is often described by empirical mathematical models. We investigated the relationship between the steepness of the concentration–effect relationship and inter-indiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8a183cffdefb4f4a7d3e5452205065
http://europepmc.org/articles/PMC7759489

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Expert Discussion of the Role of Rate Constant Versus Clearance Approaches to Define Drug Pharmacokinetics: Theoretical and Clinical Considerations

Autor: Roger W. Jelliffe, Johannes H. Proost, Marilyn N. Martinez

Publikováno v: Aaps journal, 22(2):25. SPRINGER

This article provides a dialogue covering an ongoing controversy on the use of clearance versus rate constant approaches for model parameterization when assessing pharmacokinetic (PK) data. It reflects the differences in opinions that can exist among

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e5d51996b47cb5161a2f1a21201805
https://research.rug.nl/en/publications/bd754ef5-7617-45bb-a7bb-4cccf266aaa0

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Development of a mechanistic biokinetic model for hepatic bile acid handling to predict possible cholestatic effects of drugs

Autor: Karl M. Weigand, Marola M.H. van Lipzig, Frans G. M. Russel, Sylvia Notenboom, Petra H.H. van den Broek, Geny M. M. Groothuis, Johannes H. Proost, Rick Greupink, Evita van de Steeg

Publikováno v: European Journal of Pharmaceutical Sciences, 115, pp. 175-184
European Journal of Pharmaceutical Sciences, 115, 175-184. ELSEVIER SCIENCE BV
European Journal of Pharmaceutical Sciences, 115, 175-184

Drug-induced liver injury (DILI) is a common reason for drug withdrawal from the market. An important cause of DILI is drug-induced cholestasis. One of the major players involved in drug-induced cholestasis is the bile salt efflux pump (BSEP; ABCB11)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f85c53580cf3aec25511d7a1d6d1135b
https://doi.org/10.1016/j.ejps.2018.01.007

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Predicting Drug Concentration-Time Profiles in Multiple CNS Compartments Using a Comprehensive Physiologically-Based Pharmacokinetic Model

Autor: Dirk-Jan van den Berg, Elizabeth C. M. de Lange, Pyry A. J. Välitalo, Margot W. Beukers, Johan G. C. van Hasselt, Walter Krauwinkel, An Vermeulen, Robin Hartman, Yumi Yamamoto, Meindert Danhof, Yin Cheong Wong, Dymphy Huntjens, Johannes H. Proost

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology

Drug development targeting the central nervous system (CNS) is challenging due to poor predictability of drug concentrations in various CNS compartments. We developed a generic physiologically based pharmacokinetic (PBPK) model for prediction of drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d4d715949a80a858f5da61710dffa0a
https://doi.org/10.1002/psp4.12250

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A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations

Autor: Willem van den Brink, Yin Cheong Wong, Meindert Danhof, Pyry A. J. Välitalo, Johannes H. Proost, Dymphy Huntjens, An Vermeulen, Elizabeth C. M. de Lange, William Couet, Walter Krauwinkel, Claire Dahyot-Fizelier, Dirk-Jan van den Berg, Robin Hartman, Vincent Aranzana-Climent, Sandrine Marchand, Suruchi Bakshi, Yumi Yamamoto, Johan G. C. van Hasselt

Publikováno v: Pharmaceutical Research, 34(2), 333-351. SPRINGER/PLENUM PUBLISHERS
Pharmaceutical Research
Pharmaceutical Research, 34(2), 333–351
Pharmaceutical Research, American Association of Pharmaceutical Scientists, 2017, 34 (2), pp.333-351. ⟨10.1007/s11095-016-2065-3⟩

Purpose Predicting target site drug concentration in the brain is of key importance for the successful development of drugs acting on the central nervous system. We propose a generic mathematical model to describe the pharmacokinetics in brain compar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f99545027cafeb7a51e50259063b93
https://hdl.handle.net/11370/3aa40e39-3c25-4321-922d-9c635d2c8422

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Pharmacokinetic and pharmacodynamic interactions in anaesthesia. A review of current knowledge and how it can be used to optimize anaesthetic drug administration

Autor: Hugo Vereecke, Anthony Absalom, Johann Wietasch, Douglas J. Eleveld, Johannes H. Proost, J. P. van den Berg, Michel Struys

Publikováno v: British Journal of Anaesthesia. 118:44-57

This review describes the basics of pharmacokinetic and pharmacodynamic drug interactions and methodological points of particular interest when designing drug interaction studies. It also provides an overview of the available literature concerning in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a61b3e72a63d3f629e2ee11eebe8db7d
https://doi.org/10.1093/bja/aew312

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Vancomycin pharmacokinetic model development in patients on intermittent online hemodiafiltration

Autor: Daan J Touw, Marjolijn van Buren, Erik B Wilms, Niels Westra, Casper F. M. Franssen, Johannes H. Proost

Publikováno v: PLoS ONE, 14(5):e0216801. PUBLIC LIBRARY SCIENCE
PLoS ONE, Vol 14, Iss 5, p e0216801 (2019)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1459ba8f1205d63648c2363307a761
https://research.rug.nl/en/publications/396f3dea-4566-426c-be44-ad4c51665d07

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