Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Johannes Graumann"'
Autor:
Mohamed A. Elhadad, Mónica del C. Gómez-Alonso, Chien-Wei Chen, Sonja Neumeyer, Thomas Delerue, Wolfgang Rathmann, Michael Näbauer, Christa Meisinger, Stefan Kääb, Jochen Seissler, Johannes Graumann, Wolfgang Koenig, Karsten Suhre, Christian Gieger, Uwe Völker, Annette Peters, Elke Hammer, Melanie Waldenberger
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-12 (2024)
Abstract Background and aims Atherosclerosis is the main cause of stroke and coronary heart disease (CHD), both leading mortality causes worldwide. Proteomics, as a high-throughput method, could provide helpful insights into the pathological mechanis
Externí odkaz:
https://doaj.org/article/27d62746d13f4cb9b09770b2fb66f876
Autor:
Felix Neuhaus, Sonja Lieber, Veronika Shinkevich, Anna Mary Steitz, Hartmann Raifer, Kathrin Roth, Florian Finkernagel, Thomas Worzfeld, Andreas Burchert, Corinna Keber, Andrea Nist, Thorsten Stiewe, Silke Reinartz, Vanessa M. Beutgen, Johannes Graumann, Kim Pauck, Holger Garn, Matthias Gaida, Rolf Müller, Magdalena Huber
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 4, Pp n/a-n/a (2024)
Abstract Background IL‐17A and TNF synergistically promote inflammation and tumorigenesis. Their interplay and impact on ovarian carcinoma (OC) progression are, however, poorly understood. We addressed this question focusing on mesothelial cells, w
Externí odkaz:
https://doaj.org/article/34a4cb60682e4aa7997d2f9cd82ee079
Autor:
Vanessa M. Beutgen, Johannes Graumann
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Altered protein levels in the aqueous humor (AH) may be a valuable source of novel biomarkers in neurodegenerative retinal disease. The proximity of this body fluid to the disease focus, and its corresponding enrichment for tissue specific proteins,
Externí odkaz:
https://doaj.org/article/61545760b4fe4e0ab2935d9cdb7cd9d3
Autor:
Anna Mary Steitz, Clarissa Schröder, Isabel Knuth, Corinna U. Keber, Leah Sommerfeld, Florian Finkernagel, Julia M. Jansen, Uwe Wagner, Sabine Müller-Brüsselbach, Thomas Worzfeld, Magdalena Huber, Vanessa M. Beutgen, Johannes Graumann, Elke Pogge von Strandmann, Rolf Müller, Silke Reinartz
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108401- (2023)
Summary: A crucial requirement for metastasis formation in ovarian high-grade serous carcinoma (HGSC) is the disruption of the protective peritoneal mesothelium. Using co-culture systems of primary human cells, we discovered that tumor-associated NK
Externí odkaz:
https://doaj.org/article/e9c08e3135684fc89cfce67f8891a099
Autor:
Aina Lluch, Jessica Latorre, Angela Serena-Maione, Isabel Espadas, Estefanía Caballano-Infantes, José M. Moreno-Navarrete, Núria Oliveras-Cañellas, Wifredo Ricart, María M. Malagón, Alejandro Martin-Montalvo, Walter Birchmeier, Witold Szymanski, Johannes Graumann, María Gómez-Serrano, Elena Sommariva, José M. Fernández-Real, Francisco J. Ortega
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Plakophilin-2 (PKP2) is a key component of desmosomes, which, when defective, is known to promote the fibro-fatty infiltration of heart muscle. Less attention has been given to its role in adipose tissue. We report here that levels of PKP2 s
Externí odkaz:
https://doaj.org/article/c9aab534331a4f3fa90b32b90c48e65f
Autor:
María Ángeles de Pedro, Esther López, Francisco Manuel González-Nuño, María Pulido, Verónica Álvarez, Ana María Marchena, Christian Preußer, Witold Szymański, Elke Pogge von Strandmann, Johannes Graumann, Francisco Miguel Sánchez-Margallo, Javier G. Casado, María Gómez-Serrano
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Background Mesenchymal stromal cells (MSCs) have been shown to exert their therapeutic effects through the secretion of broad spectrum of paracrine factors, including extracellular vesicles (EVs). Accordingly, EVs are being pursued as a prom
Externí odkaz:
https://doaj.org/article/6fbe152b6a68418d9e51b718ab38fc09
Autor:
Raimund Dietze, Witold Szymanski, Kaire Ojasalu, Florian Finkernagel, Andrea Nist, Thorsten Stiewe, Johannes Graumann, Rolf Müller
Publikováno v:
Cells, Vol 13, Iss 10, p 810 (2024)
Lysophosphatidic acid (LPA) species, prevalent in the tumor microenvironment (TME), adversely impact various cancers. In ovarian cancer, the 18:0 and 20:4 LPA species are selectively associated with shorter relapse-free survival, indicating distinct
Externí odkaz:
https://doaj.org/article/5ea8148ce6c84ceaa25edad6fe6fbbc0
Autor:
Karsten Grote, Ann-Christin Schaefer, Muhidien Soufi, Volker Ruppert, Uwe Linne, Aditya Mukund Bhagwat, Witold Szymanski, Johannes Graumann, Yana Gercke, Sümeya Aldudak, Denise Hilfiker-Kleiner, Elisabeth Schieffer, Bernhard Schieffer
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4522 (2024)
Here, we target the high-density lipoprotein (HDL) proteome in a case series of 16 patients with post-COVID-19 symptoms treated with HMG-Co-A reductase inhibitors (statin) plus angiotensin II type 1 receptor blockers (ARBs) for 6 weeks. Patients suff
Externí odkaz:
https://doaj.org/article/42a0da89015b4997a71cd8c5df4fc69e
Autor:
Reem Alkhayer, Viviane Ponath, Miriam Frech, Till Adhikary, Johannes Graumann, Andreas Neubauer, Elke Pogge von Strandmann
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract The immunoreceptor NKG2D, which is expressed on NK cells and T cell subsets is critically involved in tumor immune surveillance. This applies in particular to acute myeloid leukemia (AML), which evades immune detection by downregulation of N
Externí odkaz:
https://doaj.org/article/dc6b4274aced429fa28f5022f9dff929
Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2
Autor:
Rui Li, Jingchen Shao, Young-June Jin, Haruya Kawase, Yu Ting Ong, Kerstin Troidl, Qi Quan, Lei Wang, Remy Bonnavion, Astrid Wietelmann, Francoise Helmbacher, Michael Potente, Johannes Graumann, Nina Wettschureck, Stefan Offermanns
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
The authors report that endothelial protocadherin FAT1 inhibits endothelial proliferation and angiogenesis by promoting degradation of the transcriptional cofactors YAP and TAZ by direct interaction with the E3 ubiquitin ligase Mind Bomb-2 (MIB2).
Externí odkaz:
https://doaj.org/article/ae8cf225971e49d0b6bc0f0653d4b7c5