Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Johannes F. Hevler"'
Autor:
Elyse S. Fischer, Conny W. H. Yu, Johannes F. Hevler, Stephen H. McLaughlin, Sarah L. Maslen, Albert J. R. Heck, Stefan M. V. Freund, David Barford
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Formation of the mitotic checkpoint complex (MCC) is catalysed by a phosphorylation-dependent scaffold. This work provides structural details of how a tripartite Mad1:Bub1:Cdc20 complex presents Cdc20 to Mad2, triggering open-to-closed conversion of
Externí odkaz:
https://doaj.org/article/25af90ef4aa84deab038bcc19c9bacc5
Autor:
Johannes F. Hevler, Pascal Albanese, Alfredo Cabrera-Orefice, Alisa Potter, Andris Jankevics, Jelena Misic, Richard A. Scheltema, Ulrich Brandt, Susanne Arnold, Albert J. R. Heck
Publikováno v:
Open Biology, Vol 13, Iss 3 (2023)
The tricarboxylic acid cycle is the central pathway of energy production in eukaryotic cells and plays a key part in aerobic respiration throughout all kingdoms of life. One of the pivotal enzymes in this cycle is 2-oxoglutarate dehydrogenase complex
Externí odkaz:
https://doaj.org/article/6c26007c884f43f0908e9face6870b60
Autor:
Rachel J. Harding, Justin C. Deme, Johannes F. Hevler, Sem Tamara, Alexander Lemak, Jeffrey P. Cantle, Magdalena M. Szewczyk, Nola Begeja, Siobhan Goss, Xiaobing Zuo, Peter Loppnau, Alma Seitova, Ashley Hutchinson, Lixin Fan, Ray Truant, Matthieu Schapira, Jeffrey B. Carroll, Albert J. R. Heck, Susan M. Lea, Cheryl H. Arrowsmith
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Harding et al. present a biophysical and structural characterization of the complex between huntingtin (HTT) and HAP40 proteins. They show that the abundance of HAP40 is coupled with that of HTT and that there is greater conformational variety in the
Externí odkaz:
https://doaj.org/article/eb1fd59dd9ce42829c1dde1a83e58ffc
Autor:
Alfredo Cabrera-Orefice, Alisa Potter, Felix Evers, Johannes F. Hevler, Sergio Guerrero-Castillo
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2022)
Complexome profiling (CP) is a state-of-the-art approach that combines separation of native proteins by electrophoresis, size exclusion chromatography or density gradient centrifugation with tandem mass spectrometry identification and quantification.
Externí odkaz:
https://doaj.org/article/feee56a1dd134b8ea304faf8c46f695f
Autor:
null Johannes F. Hevler, null Pascal Albanese, null Alfredo Cabrera-Orefice, null Alisa Potter, null Andris Jankevics, null Jelena Misic, null Richard A. Scheltema, null Ulrich Brandt, null Susanne Arnold, null Albert J. R. Heck
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::944e45a5a96392c13a5c967b8f5435a3
https://doi.org/10.1098/rsob.220363/v2/response1
https://doi.org/10.1098/rsob.220363/v2/response1
Autor:
Johannes F. Hevler, Pascal Albanese, Alfredo Cabrera-Orefice, Alisa Potter, Andris Jankevics, Jelena Misic, Richard A. Scheltema, Ulrich Brandt, Susanne Arnold, Albert J.R. Heck
The tricarboxylic acid (TCA) cycle, or Krebs cycle, is the central pathway of energy production in eukaryotic cells and plays a key part in aerobic respiration throughout all kingdoms of life. The enzymes involved in this cycle generate the reducing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10c4b2572bbd41439ff058a3dad6a6b7
https://doi.org/10.1101/2022.10.08.511390
https://doi.org/10.1101/2022.10.08.511390
Autor:
Matthieu Schapira, Alexander Lemak, Alma Seitova, Justin C. Deme, Peter Loppnau, Cheryl H. Arrowsmith, Ashley Hutchinson, Sem Tamara, Rachel Harding, Albert J. R. Heck, Susan M. Lea, Jeffrey P. Cantle, Xiaobing Zuo, Magdalena M. Szewczyk, Johannes F. Hevler, Jeffrey B. Carroll, Lixin Fan
Huntington’s disease results from expansion of a glutamine-coding CAG tract in the huntingtin (HTT) gene, producing an aberrantly functioning form of HTT. Both wildtype and disease-state HTT form a hetero-dimer with HAP40 of unknown functional rele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10857a91400adeb011200148bab1c39c
https://doi.org/10.1101/2021.04.02.438217
https://doi.org/10.1101/2021.04.02.438217
Autor:
Susanne Arnold, Johannes F. Hevler, Ulrich Brandt, Albert J. R. Heck, Riccardo Zenezeni Chiozzi, Alfredo Cabrera-Orefice
Combining mass spectrometry based chemical cross-linking and complexome profiling, we analyzed the interactome of heart mitochondria. We focused on complexes of oxidative phosphorylation and found that dimeric apoptosis inducing factor 1 (AIFM1) form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cf9125f3fea36bdf8a7b509041897d4
https://doi.org/10.1101/2021.03.31.437858
https://doi.org/10.1101/2021.03.31.437858
Autor:
Albert J. R. Heck, Bart M. Gadella, Paula Maitan, Marc C. Roelofs, Heiko Henning, Tzviya Zeev-Ben-Mordehai, Miguel Ricardo Leung, Ravi Teja Ravi, Elizabeth G. Bromfield, Stuart C. Howes, Min Zhang, Riccardo Zenezini Chiozzi, Johannes F. Hevler
1 Mitochondria-cytoskeleton interactions modulate cellular 2 physiology by regulating mitochondrial transport, position-3 ing, and immobilization. However, there is very little struc-4 tural information defining mitochondria-cytoskeleton inter-5 face
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83288adf8e3f92a1411ec3933cbb2d77
https://doi.org/10.1101/2021.02.16.431372
https://doi.org/10.1101/2021.02.16.431372
Autor:
Marie V. Lukassen, Johannes F. Hevler, Matti F. Pronker, Alfredo Cabrera-Orefice, Vojtech Franc, Albert J. R. Heck, Susanne Arnold
Cross-linking mass spectrometry has developed into an important method to study protein structures and interactions. The in-solution cross-linking workflows involve time and sample consuming steps and do not provide sensible solutions for differentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::217d52c381cabc0e47bf9e477f126716
https://doi.org/10.1101/2020.07.10.193003
https://doi.org/10.1101/2020.07.10.193003