Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Johannes F. Coy"'
Autor:
Johannes F. Coy
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 4, p 878 (2017)
Epitope detection in monocytes (EDIM) represents a liquid biopsy exploiting the innate immune system. Activated monocytes (macrophages) phagocytose unwanted cells/cell fragments from the whole body including solid tissues. As they return to the blood
Externí odkaz:
https://doaj.org/article/9336a7f924be46a2a1c6abd73128b442
Autor:
Johannes F. Coy
Publikováno v:
gynäkologie + geburtshilfe. 21:20-24
In die Tumordiagnostik kommt Bewegung. Wahrend klassische Tumormarker bei Fruhdiagnostik oder Screening nicht bedeutsam sind, erlaubt die durchflusszytometrische Bestimmung von Biomarkern in Makrophagen eine neue Form einer nicht invasiven Diagnostik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f89b776e782e01fe4e7596ab7804fe76
https://doi.org/10.1007/s15013-016-0966-1
https://doi.org/10.1007/s15013-016-0966-1
Publikováno v:
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 121:301-306
Objectives Monocytes/macrophages are regarded as the first line of defense in tumors. Therefore, analyzing monocyte subtypes in oral squamous cell carcinoma (OSCC) may be of value in disease monitoring and to explore immunotherapeutic strategies for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e57c1b78d6033f7d21536360d15b42b
https://doi.org/10.1016/j.oooo.2015.10.024
https://doi.org/10.1016/j.oooo.2015.10.024
Autor:
Dennis Japink, Meindert N. Sosef, Math P.G. Leers, Maarten F. von Meyenfeldt, Geerard L. Beets, Marius Nap, Johannes F. Coy, Patty J. Nelemans
Publikováno v:
Journal of Immunological Methods, 407, 40-47. Elsevier Science
INTRODUCTION: We have recently described epitope detection in macrophages (EDIM) by flow cytometry. This is a promising tool for the diagnosis and follow-up of malignancies. However, biological and technical validation is warranted before clinical ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e578ad57725af474419854e15c013b15
https://doi.org/10.1016/j.jim.2014.03.018
https://doi.org/10.1016/j.jim.2014.03.018
Autor:
Peter Carmeliet, Timothy M. Thomson, Leen Notebaert, Maciek R. Antoniewicz, Marta Cascante, Mieke Dewerchin, Johannes F. Coy, Guy Eelen, Óscar Meca-Cortés, Esther Aguilar, Santiago Diaz-Moralli, Bart Ghesquière, Silvia Marin
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Oncotarget
instname
Oncotarget
Metabolic reprogramming, a crucial cancer hallmark, shifts metabolic pathways such as glycolysis, tricarboxylic acid cycle or lipogenesis, to enable the growth characteristics of cancer cells. Here, we provide evidence that transketolase-like 1 (TKTL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd7dc5808608f9e2838e7e20e486749d
http://hdl.handle.net/10261/160079
http://hdl.handle.net/10261/160079
Publikováno v:
Future Oncology. 8:1349-1359
Aim: To determine whether the TKTL1 protein epitope detection in monocytes (EDIM) test allows detection of upregulated glucose metabolism in malignancies. Materials & methods: The EDIM-TKTL1 blood test was conducted in 240 patients with 17 different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf642637e14395e1ae203bba69e9909
https://doi.org/10.2217/fon.12.98
https://doi.org/10.2217/fon.12.98
Autor:
German Ott, Johannes F. Coy, Godehard Friedel, Thomas E. Mürdter, Peter Fritz, Mark Dominik Alscher
Publikováno v:
Pathology - Research and Practice. 208:203-209
Study of the physiological changes associated with the development of malignancy demonstrates a metabolic signature for the different stages of tumorigenesis. Increased glucose uptake and lactate production have been detected during malignant transfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e4c65432d2ccc2bbe5b9c22da26844
https://doi.org/10.1016/j.prp.2012.01.007
https://doi.org/10.1016/j.prp.2012.01.007
Publikováno v:
gynäkologie + geburtshilfe. 19:60-62
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a52f8b5b71e5aa572121c44e0932348c
https://doi.org/10.1007/s15013-014-0402-3
https://doi.org/10.1007/s15013-014-0402-3
Autor:
Johannes F. Coy, Dieter H. Möller
Publikováno v:
Erfahrungsheilkunde. 58:61-69
Glucose can contribute to the fact, that a cancer cell becomes aggressive, when the energy in the cell is produced by fermentation and not by oxidation. In this process, the gene Transketolase-like-1 (TKTL1) is of vital importance: if cancer cells ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2985184060e2a152a2dde5ee89ba5db6
https://doi.org/10.1055/s-0029-1213516
https://doi.org/10.1055/s-0029-1213516
Autor:
Stephanie Sommer, Carsten Hagemann, Giles Hamilton Vince, Rainer Wittig, Imme Haubitz, Johannes F. Coy, Ulrike Kämmerer, Hans-Ullrich Völker, Camelia-Maria Monoranu, Jelena Stojic
Publikováno v:
American Journal of Clinical Pathology. 130:50-57
Transketolases link the Embden-Meyerhof pathway to the pentose phosphate pathway. An influence of p-Akt on this metabolism was described. This study was performed to compare the expression of transketolase-like 1 (TKTL1) and p-Akt in glioblastoma mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2aa2b65f30c8b059c478af11f029479
https://doi.org/10.1309/6h9844ammet82dbj
https://doi.org/10.1309/6h9844ammet82dbj