Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Johannes Doescher"'
Autor:
Tsima Abou Kors, Matthias Meier, Lena Mühlenbruch, Annika C. Betzler, Franziska Oliveri, Martin Bens, Jaya Thomas, Johann M. Kraus, Johannes Doescher, Adrian von Witzleben, Linda Hofmann, Jasmin Ezic, Diana Huber, Julian Benckendorff, Thomas F. E. Barth, Jens Greve, Patrick J. Schuler, Cornelia Brunner, Jonathan M. Blackburn, Thomas K. Hoffmann, Christian Ottensmeier, Hans A. Kestler, Hans-Georg Rammensee, Juliane S. Walz, Simon Laban
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe human leukocyte antigen complex (HLA) is essential for inducing specific immune responses to cancer by presenting tumor-associated peptides (TAP) to T cells. Overexpressed tumor associated antigens, mainly cancer-testis antigens (CTA)
Externí odkaz:
https://doaj.org/article/395296b0c62b42a7af04bb14da175331
Autor:
Johannes Doescher, Adrian von Witzleben, Konstantinos Boukas, Stephanie E. Weissinger, Gareth J. Thomas, Simon Laban, Jaya Thomas, Thomas K. Hoffmann, Christian H. Ottensmeier
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Chemoradiotherapy (CRT) is a standard treatment for advanced head and neck squamous cell carcinoma (HNSCC). Unfortunately, not all patients respond to this therapy and require further treatment, either salvage surgery or palliative therapy. The addit
Externí odkaz:
https://doaj.org/article/0f6a2dfd86bf46f089d4d00e59c62b60
Autor:
Lena Mühlenbruch, Tsima Abou-Kors, Marissa L. Dubbelaar, Leon Bichmann, Oliver Kohlbacher, Martin Bens, Jaya Thomas, Jasmin Ezić, Johann M. Kraus, Hans A. Kestler, Adrian von Witzleben, Joannis Mytilineos, Daniel Fürst, Daphne Engelhardt, Johannes Doescher, Jens Greve, Patrick J. Schuler, Marie-Nicole Theodoraki, Cornelia Brunner, Thomas K. Hoffmann, Hans-Georg Rammensee, Juliane S. Walz, Simon Laban
Publikováno v:
British Journal of Cancer. 128:1777-1787
Background The immune peptidome of OPSCC has not previously been studied. Cancer-antigen specific vaccination may improve clinical outcome and efficacy of immune checkpoint inhibitors such as PD1/PD-L1 antibodies. Methods Mapping of the OPSCC HLA lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dced82b3d981ef6845aecbb8f9e667e6
https://doi.org/10.1038/s41416-023-02197-y
https://doi.org/10.1038/s41416-023-02197-y
Autor:
Julia Butt, Tim Waterboer, Michael Pawlita, Thomas K. Hoffmann, Johannes Doescher, Marie-Nicole Theodoraki, Marlene C. Wigand, Patrick J. Schuler, Cornelia Brunner, Hans A. Kestler, Gunnar Völkel, Johann M. Kraus, Peter Möller, Ralf Marienfeld, Jasmin Ezić, Paolo Boscolo-Rizzo, Gerhard Dyckhoff, Christel C. Herold-Mende, Martina A. Broglie, Andreas Dietz, Gunnar Wichmann, Dirk Jäger, Inka Zörnig, Stefan B. Eichmüller, Lea Schroeder, Dana Holzinger, Dominik S. Gangkofner, Simon Laban
Overall survival by HPV-status. Overall survival stratified by HPV-status based on A) molecular HPV-status, B) seropositivity to HPV-16 E6, C) seropositivity to any high-risk HPV-types and D) by molecular HPV-status if available and seropositivity to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f4bf30bee3bb4df8662e93d73396bf
https://doi.org/10.1158/1078-0432.22470929.v1
https://doi.org/10.1158/1078-0432.22470929.v1
Autor:
Julia Butt, Tim Waterboer, Michael Pawlita, Thomas K. Hoffmann, Johannes Doescher, Marie-Nicole Theodoraki, Marlene C. Wigand, Patrick J. Schuler, Cornelia Brunner, Hans A. Kestler, Gunnar Völkel, Johann M. Kraus, Peter Möller, Ralf Marienfeld, Jasmin Ezić, Paolo Boscolo-Rizzo, Gerhard Dyckhoff, Christel C. Herold-Mende, Martina A. Broglie, Andreas Dietz, Gunnar Wichmann, Dirk Jäger, Inka Zörnig, Stefan B. Eichmüller, Lea Schroeder, Dana Holzinger, Dominik S. Gangkofner, Simon Laban
Patient characteristics (non-oropharyngeal patients)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8196839c19b9f3f07c4969e583cd964d
https://doi.org/10.1158/1078-0432.22470923.v1
https://doi.org/10.1158/1078-0432.22470923.v1
Autor:
Julia Butt, Tim Waterboer, Michael Pawlita, Thomas K. Hoffmann, Johannes Doescher, Marie-Nicole Theodoraki, Marlene C. Wigand, Patrick J. Schuler, Cornelia Brunner, Hans A. Kestler, Gunnar Völkel, Johann M. Kraus, Peter Möller, Ralf Marienfeld, Jasmin Ezić, Paolo Boscolo-Rizzo, Gerhard Dyckhoff, Christel C. Herold-Mende, Martina A. Broglie, Andreas Dietz, Gunnar Wichmann, Dirk Jäger, Inka Zörnig, Stefan B. Eichmüller, Lea Schroeder, Dana Holzinger, Dominik S. Gangkofner, Simon Laban
Purpose:The identification of high-risk patients within human papillomavirus (HPV)-positive and -negative head and neck squamous cell carcinoma (HNSCC) is needed for improved treatment and surveillance strategies. In this study, we set out to discove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146121ebca10785ff09a0867fe6663f7
https://doi.org/10.1158/1078-0432.c.6527735.v1
https://doi.org/10.1158/1078-0432.c.6527735.v1
Autor:
Ying-Chu CHOI, Po-Chung Chan, Kai-Wai Cheung, Jia-Jie Huang, Kwok-Leung Wong, Johannes Doescher, Tai-Chung Lam
Purpose: Malnutrition is of high prevalence in head and neck cancer (HNC) patients with weight loss being one of the major nutrition indicators. The objective of this study is to investigate the impact of weight loss on treatment interruptions and un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e333e237e6247ba4a2195d87c3edbdd8
https://doi.org/10.21203/rs.3.rs-2553707/v1
https://doi.org/10.21203/rs.3.rs-2553707/v1
Autor:
Annika C. Betzler, Hannah Strobel, Tsima Abou Kors, Jasmin Ezić, Kristina Lesakova, Ronja Pscheid, Ninel Azoitei, Johanna Sporleder, Anna-Rebekka Staufenberg, Robert Drees, Stephanie E. Weissinger, Jens Greve, Johannes Doescher, Marie-Nicole Theodoraki, Patrick J. Schuler, Simon Laban, Toshiro Kibe, Michiko Kishida, Shosei Kishida, Christian Idel, Thomas K. Hoffmann, Marialuisa Lavitrano, Emanuela Grassilli, Cornelia Brunner
Publikováno v:
Cancers; Volume 15; Issue 1; Pages: 310
Here, we describe the expression of Bruton’s Tyrosine Kinase (BTK) in head and neck squamous cell carcinoma (HNSCC) cell lines as well as in primary HNSCC samples. BTK is a kinase initially thought to be expressed exclusively in cells of hematopoie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::067b47e8094518dc123c0fafb62814d2
https://hdl.handle.net/10281/402357
https://hdl.handle.net/10281/402357
Autor:
Adrian von Witzleben, Urs Müller-Richter, Katja Maurus, Stephanie Brändlein, Marie-Nicole Theodoraki, Cornelia Brunner, Simon Laban, Jochen Lennerz, Peter Möller, Thomas K. Hoffmann, Johannes Doescher, Patrick J. Schuler
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 24; Pages: 15835
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of cancers and patients have limited therapy options if primary treatment fails. Therefore, additional information about the biology of the tumor is essential. Here we performed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e172aa73b63c5f84c50e2ce3782686b
Autor:
M-N Theodoraki, M Brand, A von Witzleben, Claudia Welke, Pj. Schuler, Tk. Hoffmann, J M Vahl, Johannes Doescher, Jens Greve, Simon Laban
Publikováno v:
European Archives of Oto-Rhino-Laryngology. 278:4535-4543
Cancer patients have to overcome various barriers to obtain diagnostics and treatment at head and neck cancer centers. Travel distance to a specialized hospital may result in psychosocial and financial distress, thus interfering with diagnostics, tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4f8699a818e29fd051c6a7a5d7acf25
https://doi.org/10.1007/s00405-021-06816-3
https://doi.org/10.1007/s00405-021-06816-3