Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Johannes CW"'
Autor:
Johannes CW Hermeling, Marija Herholz, Linda Baumann, Estela Cepeda Cores, Aleksandra Zečić, Thorsten Hoppe, Jan Riemer, Aleksandra Trifunovic
Publikováno v:
Redox Biology, Vol 58, Iss , Pp 102533- (2022)
Alternations of redox metabolism have been associated with the extension of lifespan in roundworm Caenorhabditis elegans, caused by moderate mitochondrial dysfunction, although the underlying signalling cascades are largely unknown. Previously, we id
Externí odkaz:
https://doaj.org/article/b431503942404f30838c5e9c463607a3
Autor:
Johannes Cw Hermeling, Hasse M Bossenbroek, Mélanie Héroult, Laura Schöckel, Werner J.H. Koopman, Lisanne M.P.E. van Oppen, Farhan Basit, Sander Grefte, Sjenet E. van Emst-de Vries, Charlotte Christine Kopitz, Peter H.G.M. Willems
Publikováno v:
Cell Death & Disease, 8(3)
Cell Death and Disease, 8, e2716-e2716
Cell Death & Disease
Cell Death and Disease, 8, 3, pp. e2716-e2716
Cell Death & Disease 8 (2017) 3
Cell Death and Disease, 8, e2716-e2716
Cell Death & Disease
Cell Death and Disease, 8, 3, pp. e2716-e2716
Cell Death & Disease 8 (2017) 3
Inhibition of complex I (CI) of the mitochondrial respiratory chain by BAY 87-2243 (‘BAY’) triggers death of BRAFV600E melanoma cell lines and inhibits in vivo tumor growth. Here we studied the mechanism by which this inhibition induces melanoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544da234dd63742f1a2b0b78010d5719
https://research.wur.nl/en/publications/mitochondrial-complex-i-inhibition-triggers-a-mitophagy-dependent
https://research.wur.nl/en/publications/mitochondrial-complex-i-inhibition-triggers-a-mitophagy-dependent
Akademický článek
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Akademický článek
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Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists.
Autor:
Chandramohan A; MSD International, Singapore, 138665, Singapore., Josien H; Merck & Co., Inc., Kenilworth, NJ, 07033, USA., Yuen TY; Institute of Sustainability for Chemicals, Energy and Environment, Agency for Science, Technology and Research (ASTAR), Singapore, 138665, Singapore., Duggal R; Merck & Co., Inc., Boston, MA, 02115, USA., Spiegelberg D; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Yan L; Merck & Co., Inc., Kenilworth, NJ, 07033, USA., Juang YA; MSD International, Singapore, 138665, Singapore., Ge L; Merck & Co., Inc., Kenilworth, NJ, 07033, USA., Aronica PG; Bioinformatics Institute, Agency for Science, Technology and Research (ASTAR), Singapore, 138671, Singapore., Kaan HYK; MSD International, Singapore, 138665, Singapore., Lim YH; Institute of Sustainability for Chemicals, Energy and Environment, Agency for Science, Technology and Research (ASTAR), Singapore, 138665, Singapore., Peier A; Merck & Co., Inc., Kenilworth, NJ, 07033, USA., Sherborne B; Merck & Co., Inc., Kenilworth, NJ, 07033, USA., Hochman J; Merck & Co., Inc., West Point, PA, 19486, USA., Lin S; Merck & Co., Inc., Kenilworth, NJ, 07033, USA., Biswas K; Merck & Co., Inc., Boston, MA, 02115, USA., Nestor M; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Verma CS; Bioinformatics Institute, Agency for Science, Technology and Research (ASTAR), Singapore, 138671, Singapore., Lane DP; Institute of Molecular and Cell Biology, Singapore, 138673, Singapore., Sawyer TK; Merck & Co., Inc., Boston, MA, 02115, USA., Garbaccio R; Merck & Co., Inc., Kenilworth, NJ, 07033, USA., Henry B; MSD International, Singapore, 138665, Singapore. brian.henry3@msd.com., Kannan S; Bioinformatics Institute, Agency for Science, Technology and Research (ASTAR), Singapore, 138671, Singapore. raghavk@bii.a-star.edu.sg., Brown CJ; Institute of Molecular and Cell Biology, Singapore, 138673, Singapore. CJBrown@imcb.a-star.edu.sg., Johannes CW; Institute of Sustainability for Chemicals, Energy and Environment, Agency for Science, Technology and Research (ASTAR), Singapore, 138665, Singapore. cwjohannes@gmail.com.; Institute of Molecular and Cell Biology, Singapore, 138673, Singapore. cwjohannes@gmail.com.; EPOC Scientific LLC, Stoneham, MA, 02180, USA. cwjohannes@gmail.com., Partridge AW; MSD International, Singapore, 138665, Singapore. partridge.anthony@gene.com.; Genentech, South San Francisco, CA, 94080, USA. partridge.anthony@gene.com.
Publikováno v:
Nature communications [Nat Commun] 2024 Jan 12; Vol. 15 (1), pp. 489. Date of Electronic Publication: 2024 Jan 12.
Autor:
Jelinska C; NTU Institute of Structural Biology, Experimental Medicine Building Level 06-01, 59 Nanyang Drive 636921 Singapore csiclar@nus.edu.sg.; NTU School of Biological Sciences, 60 Nanyang Drive 637551 Singapore chandra@bii.a-star.edu.sg.; NTU Lee Kong Chian School of Medicine, Experimental Medicine Building, 59 Nanyang Drive 636921 Singapore., Kannan S; Bioinformatics institute (A*STAR), 30 Biopolis Street, Matrix Level 07-01 138671 Singapore., Frosi Y; DITL, Institute of Cellular and Molecular Biology (A*STAR), 8a Biomedical Grove 138648 Singapore., Ramlan SR; DITL, Institute of Cellular and Molecular Biology (A*STAR), 8a Biomedical Grove 138648 Singapore., Winnerdy F; NTU Institute of Structural Biology, Experimental Medicine Building Level 06-01, 59 Nanyang Drive 636921 Singapore csiclar@nus.edu.sg., Lakshminarayanan R; Ocular Infections and Anti-Microbials Research Group, Singapore Eye Research Institute, The Academia, 20 College Road Singapore 169856 Singapore.; Department of Pharmacy, National University of Singapore Singapore 117543 Singapore.; Academic Clinical Program in Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School 169857 Singapore., Johannes CW; DITL, Institute of Cellular and Molecular Biology (A*STAR), 8a Biomedical Grove 138648 Singapore., Brown CJ; DITL, Institute of Cellular and Molecular Biology (A*STAR), 8a Biomedical Grove 138648 Singapore., Phan AT; NTU Institute of Structural Biology, Experimental Medicine Building Level 06-01, 59 Nanyang Drive 636921 Singapore csiclar@nus.edu.sg.; NTU School of Physical and Mathematical Sciences. 21 Nanyang link 637371 Singapore., Rhodes D; NTU Institute of Structural Biology, Experimental Medicine Building Level 06-01, 59 Nanyang Drive 636921 Singapore csiclar@nus.edu.sg.; NTU School of Biological Sciences, 60 Nanyang Drive 637551 Singapore chandra@bii.a-star.edu.sg.; NTU Lee Kong Chian School of Medicine, Experimental Medicine Building, 59 Nanyang Drive 636921 Singapore., Verma CS; NTU School of Biological Sciences, 60 Nanyang Drive 637551 Singapore chandra@bii.a-star.edu.sg.; Bioinformatics institute (A*STAR), 30 Biopolis Street, Matrix Level 07-01 138671 Singapore.; Department of Biological Sciences, National University of Singapore Block S3 #05-01 16 Science Drive 4 117558 Singapore.
Publikováno v:
RSC chemical biology [RSC Chem Biol] 2023 Oct 11; Vol. 4 (12), pp. 1096-1110. Date of Electronic Publication: 2023 Oct 11 (Print Publication: 2023).
Autor:
Chen Z; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Republic of Singapore.; Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science, Technology and Research (A*STAR), 8 Biomedical Grove, #07-01 Neuros, Singapore 138665, Republic of Singapore., Lim YW; Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science, Technology and Research (A*STAR), 8 Biomedical Grove, #07-01 Neuros, Singapore 138665, Republic of Singapore., Neo JY; Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science, Technology and Research (A*STAR), 8 Biomedical Grove, #07-01 Neuros, Singapore 138665, Republic of Singapore., Ting Chan RS; Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science, Technology and Research (A*STAR), 8 Biomedical Grove, #07-01 Neuros, Singapore 138665, Republic of Singapore., Koh LQ; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Republic of Singapore.; Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science, Technology and Research (A*STAR), 8 Biomedical Grove, #07-01 Neuros, Singapore 138665, Republic of Singapore., Yuen TY; Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science, Technology and Research (A*STAR), 8 Biomedical Grove, #07-01 Neuros, Singapore 138665, Republic of Singapore., Lim YH; Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science, Technology and Research (A*STAR), 8 Biomedical Grove, #07-01 Neuros, Singapore 138665, Republic of Singapore., Johannes CW; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Republic of Singapore., Gates ZP; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Republic of Singapore.; Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science, Technology and Research (A*STAR), 8 Biomedical Grove, #07-01 Neuros, Singapore 138665, Republic of Singapore.
Publikováno v:
Analytical chemistry [Anal Chem] 2023 Oct 10; Vol. 95 (40), pp. 14870-14878. Date of Electronic Publication: 2023 Sep 19.
Autor:
Kasper SH; Merck & Co., Inc. Cambridge Massachusetts USA., Otten S; Merck & Co., Inc. Cambridge Massachusetts USA., Squadroni B; Merck & Co., Inc. West Point Pennsylvania USA., Orr-Terry C; Merck & Co., Inc. Cambridge Massachusetts USA., Kuang Y; Merck & Co., Inc. Cambridge Massachusetts USA., Mussallem L; Merck & Co., Inc. West Point Pennsylvania USA., Ge L; Merck & Co., Inc. Kenilworth New Jersey USA., Yan L; Merck & Co., Inc. Kenilworth New Jersey USA., Kannan S; Agency for Science, Technology and Research (A*STAR) Singapore Singapore., Verma CS; Agency for Science, Technology and Research (A*STAR) Singapore Singapore., Brown CJ; Agency for Science, Technology and Research (A*STAR) Singapore Singapore., Johannes CW; Agency for Science, Technology and Research (A*STAR) Singapore Singapore., Lane DP; Agency for Science, Technology and Research (A*STAR) Singapore Singapore., Chandramohan A; MSD International Singapore Singapore., Partridge AW; MSD International Singapore Singapore., Roberts LR; Merck & Co., Inc. Cambridge Massachusetts USA., Josien H; Merck & Co., Inc. Kenilworth New Jersey USA., Therien AG; Merck & Co., Inc. Cambridge Massachusetts USA., Hett EC; Merck & Co., Inc. Cambridge Massachusetts USA., Howell BJ; Merck & Co., Inc. West Point Pennsylvania USA., Peier A; Merck & Co., Inc. Kenilworth New Jersey USA., Ai X; Merck & Co., Inc. Kenilworth New Jersey USA., Cassaday J; Merck & Co., Inc. West Point Pennsylvania USA.
Publikováno v:
Bioengineering & translational medicine [Bioeng Transl Med] 2023 May 13; Vol. 8 (5), pp. e10542. Date of Electronic Publication: 2023 May 13 (Print Publication: 2023).
Autor:
Hermeling JC; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Germany; Institute for Mitochondrial Diseases and Ageing, Medical Faculty, University of Cologne, Cologne, D-50931, Germany., Herholz M; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Germany; Institute for Mitochondrial Diseases and Ageing, Medical Faculty, University of Cologne, Cologne, D-50931, Germany., Baumann L; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Germany; Institute for Mitochondrial Diseases and Ageing, Medical Faculty, University of Cologne, Cologne, D-50931, Germany., Cores EC; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Germany; Institute for Mitochondrial Diseases and Ageing, Medical Faculty, University of Cologne, Cologne, D-50931, Germany., Zečić A; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Germany; Institute for Mitochondrial Diseases and Ageing, Medical Faculty, University of Cologne, Cologne, D-50931, Germany., Hoppe T; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Germany; Center for Molecular Medicine Cologne (CMMC), Cologne, D-50931, Germany; Institute for Genetics, University of Cologne, Cologne, D-50674, Germany., Riemer J; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Germany; Institute for Biochemistry, University of Cologne, Cologne, D-50931, Germany., Trifunovic A; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Germany; Institute for Mitochondrial Diseases and Ageing, Medical Faculty, University of Cologne, Cologne, D-50931, Germany; Center for Molecular Medicine Cologne (CMMC), Cologne, D-50931, Germany. Electronic address: aleksandra.trifunovic@uk-koeln.de.
Publikováno v:
Redox biology [Redox Biol] 2022 Dec; Vol. 58, pp. 102533. Date of Electronic Publication: 2022 Nov 19.
Autor:
Lim S; MSD International Singapore 138665 Singapore awpartridge@gmail.com., Boyer N; Merck & Co., Inc. Boston Massachusetts 02115 USA kaustav.biswas@merck.com., Boo N; MSD International Singapore 138665 Singapore awpartridge@gmail.com., Huang C; Merck & Co., Inc. Boston Massachusetts 02115 USA kaustav.biswas@merck.com., Venkatachalam G; MSD International Singapore 138665 Singapore awpartridge@gmail.com., Angela Juang YC; MSD International Singapore 138665 Singapore awpartridge@gmail.com., Garrigou M; Merck & Co., Inc. Boston Massachusetts 02115 USA kaustav.biswas@merck.com., Kaan HYK; MSD International Singapore 138665 Singapore awpartridge@gmail.com., Duggal R; Merck & Co., Inc. Boston Massachusetts 02115 USA kaustav.biswas@merck.com., Peh KM; MSD International Singapore 138665 Singapore awpartridge@gmail.com., Sadruddin A; MSD International Singapore 138665 Singapore awpartridge@gmail.com., Gopal P; MSD International Singapore 138665 Singapore awpartridge@gmail.com., Yuen TY; Agency for Science, Technology and Research (ASTAR) Singapore 138665 Singapore cwjohannes@gmail.com., Ng S; Agency for Science, Technology and Research (ASTAR) Singapore 138665 Singapore cwjohannes@gmail.com., Kannan S; Agency for Science, Technology and Research (ASTAR) Singapore 138665 Singapore cwjohannes@gmail.com., Brown CJ; Agency for Science, Technology and Research (ASTAR) Singapore 138665 Singapore cwjohannes@gmail.com., Verma CS; Agency for Science, Technology and Research (ASTAR) Singapore 138665 Singapore cwjohannes@gmail.com., Orth P; Merck & Co., Inc. Kenilworth New Jersey 07033 USA., Peier A; Merck & Co., Inc. Kenilworth New Jersey 07033 USA., Ge L; Merck & Co., Inc. Kenilworth New Jersey 07033 USA., Yu X; Merck & Co., Inc. West Point Pennsylvania 19486 USA., Bhatt B; Merck & Co., Inc. West Point Pennsylvania 19486 USA., Chen F; Merck & Co., Inc. West Point Pennsylvania 19486 USA., Wang E; Merck & Co., Inc. West Point Pennsylvania 19486 USA., Li NJ; Merck & Co., Inc. West Point Pennsylvania 19486 USA., Gonzales RJ; Merck & Co., Inc. West Point Pennsylvania 19486 USA., Stoeck A; Merck & Co., Inc. Boston Massachusetts 02115 USA kaustav.biswas@merck.com., Henry B; MSD International Singapore 138665 Singapore awpartridge@gmail.com., Sawyer TK; Merck & Co., Inc. Boston Massachusetts 02115 USA kaustav.biswas@merck.com., Lane DP; Agency for Science, Technology and Research (ASTAR) Singapore 138665 Singapore cwjohannes@gmail.com., Johannes CW; Agency for Science, Technology and Research (ASTAR) Singapore 138665 Singapore cwjohannes@gmail.com., Biswas K; Merck & Co., Inc. Boston Massachusetts 02115 USA kaustav.biswas@merck.com., Partridge AW; MSD International Singapore 138665 Singapore awpartridge@gmail.com.
Publikováno v:
Chemical science [Chem Sci] 2021 Nov 25; Vol. 12 (48), pp. 15975-15987. Date of Electronic Publication: 2021 Nov 25 (Print Publication: 2021).