Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Johannes C.M. Schlachetzki"'
Autor:
Patrick Süß, Alana Hoffmann, Tobias Rothe, Zhengyu Ouyang, Wolfgang Baum, Ori Staszewski, Georg Schett, Marco Prinz, Gerhard Krönke, Christopher K. Glass, Jürgen Winkler, Johannes C.M. Schlachetzki
Publikováno v:
Cell Reports, Vol 30, Iss 12, Pp 4082-4095.e6 (2020)
Summary: Systemic immune dysregulation contributes to the development of neuropsychiatric and neurodegenerative diseases. The precise effect of chronic peripheral immune stimulation on myeloid cells across anatomical brain regions is unclear. Here, w
Externí odkaz:
https://doaj.org/article/bd22cf9222c14c19a516a5d90377ff74
Autor:
Yongsung Kim, Xinde Zheng, Zoya Ansari, Mark C. Bunnell, Joseph R. Herdy, Larissa Traxler, Hyungjun Lee, Apua C.M. Paquola, Chrysanthi Blithikioti, Manching Ku, Johannes C.M. Schlachetzki, Jürgen Winkler, Frank Edenhofer, Christopher K. Glass, Andres A. Paucar, Baptiste N. Jaeger, Son Pham, Leah Boyer, Benjamin C. Campbell, Tony Hunter, Jerome Mertens, Fred H. Gage
Publikováno v:
Cell Reports, Vol 23, Iss 9, Pp 2550-2558 (2018)
Mitochondria are a major target for aging and are instrumental in the age-dependent deterioration of the human brain, but studying mitochondria in aging human neurons has been challenging. Direct fibroblast-to-induced neuron (iN) conversion yields fu
Externí odkaz:
https://doaj.org/article/745b25dfd2684290864d22273782c442
Publikováno v:
Brazilian Journal of Psychiatry, Vol 35, Iss suppl 2, Pp S92-S100 (2013)
Neurodegenerative diseases are pathological conditions that have an insidious onset and chronic progression. Different models have been established to study these diseases in order to understand their underlying mechanisms and to investigate new ther
Externí odkaz:
https://doaj.org/article/ad9c71849a89417985ddf6454a1144f7
Autor:
Rafael T. Han, Ilia D. Vainchtein, Johannes C.M. Schlachetzki, Frances S. Cho, Leah C. Dorman, Eunji Ahn, Dong Kyu Kim, Jerika J. Barron, Hiromi Nakao-Inoue, Ari B. Molofsky, Christopher K. Glass, Jeanne T. Paz, Anna V. Molofsky
Publikováno v:
The Journal of experimental medicine, vol 220, iss 2
Microglia are critical regulators of brain development that engulf synaptic proteins during postnatal synapse remodeling. However, the mechanisms through which microglia sense the brain environment are not well defined. Here, we characterized the reg
Autor:
Joseph R. Herdy, Larissa Traxler, Ravi K. Agarwal, Lukas Karbacher, Johannes C.M. Schlachetzki, Lena Boehnke, Dina Zangwill, Doug Galasko, Christopher K. Glass, Jerome Mertens, Fred H. Gage
Publikováno v:
Cell Stem Cell
The concept of senescence as a phenomenon limited to proliferating cells has been challenged by growing evidence of senescence-like features in terminally differentiated cells, including neurons. The persistence of senescent cells late in life is ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9086903782b873f3bf38da30838300c7
https://europepmc.org/articles/PMC10093780/
https://europepmc.org/articles/PMC10093780/
Autor:
Reem Abdel-Haq, Johannes C.M. Schlachetzki, Joseph C. Boktor, Thaisa M. Cantu-Jungles, Taren Thron, Mengying Zhang, John W. Bostick, Tahmineh Khazaei, Sujatha Chilakala, Livia H. Morais, Greg Humphrey, Ali Keshavarzian, Jonathan E. Katz, Matt Thomson, Rob Knight, Viviana Gradinaru, Bruce R. Hamaker, Christopher K. Glass, Sarkis K. Mazmanian
Parkinson’s disease (PD) is a movement disorder characterized by neuroinflammation, α-synuclein pathology, and neurodegeneration. Most cases of PD are non-hereditary, suggesting a strong role for environmental factors, and it has been speculated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe6626d20e5651ffb76be99ca581efc3
https://escholarship.org/uc/item/91s3d9q7
https://escholarship.org/uc/item/91s3d9q7
Autor:
Simon T. Schafer, Abed AlFatah Mansour, Johannes C.M. Schlachetzki, Monique Pena, Saeed Ghassemzadeh, Lisa Mitchell, Amanda Mar, Daphne Quang, Sarah Stumpf, Irene Santisteban Ortiz, Addison J. Lana, Clara Baek, Raghad Zaghal, Christopher K. Glass, Axel Nimmerjahn, Fred H. Gage
Publikováno v:
Cell. 186:2111-2126.e20
Autor:
Reem Abdel-haq, Sarkis Mazmanian, Johannes C.M. Schlachetzki, Joseph C. Boktor, Thaisa M. Cantu-Jungles, Taren Thron, Mengying Zhang, John W. Bostick, Tahmineh Khazaei, Sujatha Chilakala, Livia H. Morais, Greg Humphrey, Ali Keshavarzian, Bruce R. Hamaker, Jonathan E. Katz, Matt Thomson, Rob Knight, Christopher K. Glass, Viviana Gradinaru
Parkinson’s disease (PD) is a movement disorder characterized by neuroinflammation, α-synuclein pathology, and neurodegeneration. Most cases of PD are non-hereditary, suggesting a strong role for environmental factors, and it has been speculated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a8783611bbd2b33b07b1984619bc76
Autor:
Maud Gratuze, Johannes C.M. Schlachetzki, Ricardo D’Oliveira Albanus, Nimansha Jain, Brenna Novotny, Logan Brase, Lea Rodriguez, Clayton Mansel, Michal Kipnis, Sydney O’Brien, Martina P. Pasillas, Choonghee Lee, Melissa Manis, Marco Colonna, Oscar Harari, Christopher K. Glass, Jason D. Ulrich, David M. Holtzman
Publikováno v:
Neuron.
In addition to tau and Aβ pathologies, inflammation plays an important role in Alzheimer's disease (AD). Variants in APOE and TREM2 increase AD risk. ApoE4 exacerbates tau-linked neurodegeneration and inflammation in P301S tau mice and removal of mi
Publikováno v:
Current opinion in neurobiology. 77
Cognitive impairment in individuals infected with HIV is highly prevalent despite life-long antiretroviral therapy. A growing line of evidence suggests that the human brain serves as a sanctuary for HIV persistence. Microglia, the innate immune cells