Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Johannes C Melms"'
Autor:
Charles G Drake, Benjamin Izar, Casey R Ager, Aleksandar Obradovic, Matthew Chaimowitz, Catherine Spina, Mingxuan Zhang, Shruti Bansal, Somnath Tagore, Collin Jugler, Meri Rogava, Johannes C Melms, Patrick McCann, Matthew C Dallos
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 9 (2023)
Current methods for biomarker discovery and target identification in immuno-oncology rely on static snapshots of tumor immunity. To thoroughly characterize the temporal nature of antitumor immune responses, we developed a 34-parameter spectral flow c
Externí odkaz:
https://doaj.org/article/e9829ce92dbf4e9c97cb167d068ea152
Autor:
Huachao Huang, Yinshan Fang, Ming Jiang, Yihan Zhang, Jana Biermann, Johannes C Melms, Jennifer A Danielsson, Ying Yang, Li Qiang, Jia Liu, Yiwu Zhou, Manli Wang, Zhihong Hu, Timothy C Wang, Anjali Saqi, Jie Sun, Ichiro Matsumoto, Wellington V Cardoso, Charles W Emala, Jian Zhu, Benjamin Izar, Hongmei Mou, Jianwen Que
Publikováno v:
eLife, Vol 11 (2022)
Viral infection often causes severe damage to the lungs, leading to the appearance of ectopic basal cells (EBCs) and tuft cells in the lung parenchyma. Thus far, the roles of these ectopic epithelial cells in alveolar regeneration remain controversia
Externí odkaz:
https://doaj.org/article/a89690d63c0b4788974d3765d808f613
Autor:
Samuel F. Bakhoum, Benjamin Izar, Eileen E. Parkes, Alexander N. Shoushtari, Charles Swanton, Olivier Elemento, Jedd D. Wolchok, Simon N. Powell, Neil Vasan, Anusha Kalbasi, Shin-San Michael Su, Nadeem Riaz, Jorge S. Reis-Filho, Hannah Y. Wen, Taha Merghoub, Travis J. Hollmann, Benjamin J. DiPardo, Lee Gottesdiener, Chantal Pauli, Peng Li, Julie-Ann Cavallo, Princesca Dorsaint, Maria Laura Martin, Hao Wei Li, Rohan Bareja, Dhruva Biswas, Ieva Usaite, Kevin Litchfield, Sreeram Vallabhaneni, Johannes C. Melms, Matthew G. Hanna, Jacqueline A. James, Manuel Salto-Tellez, Matthew P. Humphries, Roshan K. Sriram, John Kwon, Sarah E. Bettigole, Walid K. Chatila, Ninjit Dhanota, Mercedes A. Duran, Jun Li
Supplementary Figures and Methods in PDF format
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635ea996437975f580871317155e428c
https://doi.org/10.1158/2159-8290.22540268.v1
https://doi.org/10.1158/2159-8290.22540268.v1
Autor:
Samuel F. Bakhoum, Benjamin Izar, Eileen E. Parkes, Alexander N. Shoushtari, Charles Swanton, Olivier Elemento, Jedd D. Wolchok, Simon N. Powell, Neil Vasan, Anusha Kalbasi, Shin-San Michael Su, Nadeem Riaz, Jorge S. Reis-Filho, Hannah Y. Wen, Taha Merghoub, Travis J. Hollmann, Benjamin J. DiPardo, Lee Gottesdiener, Chantal Pauli, Peng Li, Julie-Ann Cavallo, Princesca Dorsaint, Maria Laura Martin, Hao Wei Li, Rohan Bareja, Dhruva Biswas, Ieva Usaite, Kevin Litchfield, Sreeram Vallabhaneni, Johannes C. Melms, Matthew G. Hanna, Jacqueline A. James, Manuel Salto-Tellez, Matthew P. Humphries, Roshan K. Sriram, John Kwon, Sarah E. Bettigole, Walid K. Chatila, Ninjit Dhanota, Mercedes A. Duran, Jun Li
Cytosolic DNA is characteristic of chromosomally unstable metastatic cancer cells, resulting in constitutive activation of the cGAS–STING innate immune pathway. How tumors co-opt inflammatory signaling while evading immune surveillance remains unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af51a233154e60a4e2bb2d77e8270d96
https://doi.org/10.1158/2159-8290.c.6549335
https://doi.org/10.1158/2159-8290.c.6549335
Autor:
Benjamin Izar, Peter K. Sorger, Kai W. Wucherpfennig, Nicolo Riggi, Dirk Schadendorf, Alexander Spektor, David M. Miller, Titus J. Brinker, Shaolin Mei, Adrienne Luoma, Adam N.R. Cartwright, Meri Rogava, Kartik Subramanian, Steven Rodriguez, Nienke Moret, Derrick Deming, Sushil Kumar, Patricia Waszyk, Eugenio Morelli, Jia-Yun Chen, Clarence Yapp, Caitlin E. Mills, Sreeram Vallabhaneni, Johannes C. Melms
Video Control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3237604ff2aef693a606b4656d387ffb
https://doi.org/10.1158/0008-5472.22424536.v1
https://doi.org/10.1158/0008-5472.22424536.v1
Autor:
Benjamin Izar, Peter K. Sorger, Kai W. Wucherpfennig, Nicolo Riggi, Dirk Schadendorf, Alexander Spektor, David M. Miller, Titus J. Brinker, Shaolin Mei, Adrienne Luoma, Adam N.R. Cartwright, Meri Rogava, Kartik Subramanian, Steven Rodriguez, Nienke Moret, Derrick Deming, Sushil Kumar, Patricia Waszyk, Eugenio Morelli, Jia-Yun Chen, Clarence Yapp, Caitlin E. Mills, Sreeram Vallabhaneni, Johannes C. Melms
Suppl. F1: On-target activity and toxicity of CX-6258 Suppl. F2: On-target activity of CX-6258 and siRNA KD of Haspin Suppl. F3: Effects of CX-6258 on cell-cycle and cGAS recruitment Suppl. F4: In vivo effects of CX-6258
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43780310e141ae60c3bee4c382b66886
https://doi.org/10.1158/0008-5472.22424545.v1
https://doi.org/10.1158/0008-5472.22424545.v1
Autor:
Benjamin Izar, Peter K. Sorger, Kai W. Wucherpfennig, Nicolo Riggi, Dirk Schadendorf, Alexander Spektor, David M. Miller, Titus J. Brinker, Shaolin Mei, Adrienne Luoma, Adam N.R. Cartwright, Meri Rogava, Kartik Subramanian, Steven Rodriguez, Nienke Moret, Derrick Deming, Sushil Kumar, Patricia Waszyk, Eugenio Morelli, Jia-Yun Chen, Clarence Yapp, Caitlin E. Mills, Sreeram Vallabhaneni, Johannes C. Melms
Suppl. Table 1: Compounds used in drug screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e33535b11bcb7c5abea9a3aea35e5f4
https://doi.org/10.1158/0008-5472.22424542
https://doi.org/10.1158/0008-5472.22424542
Autor:
Benjamin Izar, Peter K. Sorger, Kai W. Wucherpfennig, Nicolo Riggi, Dirk Schadendorf, Alexander Spektor, David M. Miller, Titus J. Brinker, Shaolin Mei, Adrienne Luoma, Adam N.R. Cartwright, Meri Rogava, Kartik Subramanian, Steven Rodriguez, Nienke Moret, Derrick Deming, Sushil Kumar, Patricia Waszyk, Eugenio Morelli, Jia-Yun Chen, Clarence Yapp, Caitlin E. Mills, Sreeram Vallabhaneni, Johannes C. Melms
Patients with melanoma resistant to RAF/MEK inhibitors (RMi) are frequently resistant to other therapies, such as immune checkpoint inhibitors (ICI), and individuals succumb to their disease. New drugs that control tumor growth and favorably modulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2891e1ec303291c1ea2162f2b73af53b
https://doi.org/10.1158/0008-5472.c.6511807.v1
https://doi.org/10.1158/0008-5472.c.6511807.v1
Autor:
Benjamin Izar, Peter K. Sorger, Kai W. Wucherpfennig, Nicolo Riggi, Dirk Schadendorf, Alexander Spektor, David M. Miller, Titus J. Brinker, Shaolin Mei, Adrienne Luoma, Adam N.R. Cartwright, Meri Rogava, Kartik Subramanian, Steven Rodriguez, Nienke Moret, Derrick Deming, Sushil Kumar, Patricia Waszyk, Eugenio Morelli, Jia-Yun Chen, Clarence Yapp, Caitlin E. Mills, Sreeram Vallabhaneni, Johannes C. Melms
Methods and Suppl. Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1274467e9887ffe96759fa0e782083a6
https://doi.org/10.1158/0008-5472.22424548
https://doi.org/10.1158/0008-5472.22424548
Autor:
Casey R. Ager, Mingxuan Zhang, Matthew Chaimowitz, Shruti Bansal, Aleksandar Obradovic, Meri Rogava, Johannes C. Melms, Patrick McCann, Catherine Spina, Charles G. Drake, Matthew C. Dallos, Benjamin Izar
Publikováno v:
bioRxiv
Current methods for biomarker discovery and target identification in immuno-oncology rely on static snapshots of tumor immunity. To thoroughly characterize the temporal nature of antitumor immune responses, we developed a 34-parameter spectral flow c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128612c8fc76e22b3ac3869baaba18b5
https://europepmc.org/articles/PMC9881861/
https://europepmc.org/articles/PMC9881861/