Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Johannes C, Hellmuth"'
Statistical biases due to anonymization evaluated in an open clinical dataset from COVID-19 patients
Autor:
Carolin E. M. Koll, Sina M. Hopff, Thierry Meurers, Chin Huang Lee, Mirjam Kohls, Christoph Stellbrink, Charlotte Thibeault, Lennart Reinke, Sarah Steinbrecher, Stefan Schreiber, Lazar Mitrov, Sandra Frank, Olga Miljukov, Johanna Erber, Johannes C. Hellmuth, Jens-Peter Reese, Fridolin Steinbeis, Thomas Bahmer, Marina Hagen, Patrick Meybohm, Stefan Hansch, István Vadász, Lilian Krist, Steffi Jiru-Hillmann, Fabian Prasser, Jörg Janne Vehreschild, NAPKON Study Group
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-15 (2022)
Abstract Anonymization has the potential to foster the sharing of medical data. State-of-the-art methods use mathematical models to modify data to reduce privacy risks. However, the degree of protection must be balanced against the impact on statisti
Externí odkaz:
https://doaj.org/article/28a3080393434801b72639368e05f863
Autor:
Bernd Uhl, Florian Haring, Julia Slotta-Huspenina, Joshua Luft, Vera Schneewind, Jonas Hildinger, Zhengquan Wu, Katja Steiger, Bojan Smiljanov, Aarif M. N. Batcha, Oliver T. Keppler, Johannes C. Hellmuth, Tobias Lahmer, Konrad Stock, Bernhard G. Weiss, Martin Canis, Konstantin Stark, Thomas Bromberger, Markus Moser, Christian Schulz, Wilko Weichert, Gabriele Zuchtriegel, Christoph A. Reichel
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Microvascular immunothrombotic dysregulation is a critical process in the pathogenesis of severe systemic inflammatory diseases. The mechanisms controlling immunothrombosis in inflamed microvessels, however, remain poorly understood. Here, we report
Externí odkaz:
https://doaj.org/article/ade407ee878a42518dbdd312efef54f7
Autor:
Kami Pekayvaz, Alexander Leunig, Rainer Kaiser, Markus Joppich, Sophia Brambs, Aleksandar Janjic, Oliver Popp, Daniel Nixdorf, Valeria Fumagalli, Nora Schmidt, Vivien Polewka, Afra Anjum, Viktoria Knottenberg, Luke Eivers, Lucas E. Wange, Christoph Gold, Marieluise Kirchner, Maximilian Muenchhoff, Johannes C. Hellmuth, Clemens Scherer, Raquel Rubio-Acero, Tabea Eser, Flora Deák, Kerstin Puchinger, Niklas Kuhl, Andreas Linder, Kathrin Saar, Lukas Tomas, Christian Schulz, Andreas Wieser, Wolfgang Enard, Inge Kroidl, Christof Geldmacher, Michael von Bergwelt-Baildon, Oliver T. Keppler, Mathias Munschauer, Matteo Iannacone, Ralf Zimmer, Philipp Mertins, Norbert Hubner, Michael Hoelscher, Steffen Massberg, Konstantin Stark, Leo Nicolai
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Infection with SARS-COV-2 can result in self-limited upper airway infection or progress to a more systemic inflammatory condition including pneumonic COVID-19. Here the authors utilise a multi-omics approach to interrogate the immune response of pati
Externí odkaz:
https://doaj.org/article/25f8c8382ab44535bbd9a714a216c8f8
Autor:
Lisa Rausch, Konstantin Lutz, Martina Schifferer, Elena Winheim, Rudi Gruber, Elina F. Oesterhaus, Linus Rinke, Johannes C. Hellmuth, Clemens Scherer, Maximilian Muenchhoff, Christopher Mandel, Michael Bergwelt‐Baildon, Mikael Simons, Tobias Straub, Anne B. Krug, Jan Kranich, Thomas Brocker
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 14, Pp n/a-n/a (2021)
Abstract Infection with SARS‐CoV‐2 is associated with thromboinflammation, involving thrombotic and inflammatory responses, in many COVID‐19 patients. In addition, immune dysfunction occurs in patients characterised by T cell exhaustion and sev
Externí odkaz:
https://doaj.org/article/90e56d7dcd8c4e7da4606b3b096736f2
Autor:
Elena Winheim, Linus Rinke, Konstantin Lutz, Anna Reischer, Alexandra Leutbecher, Lina Wolfram, Lisa Rausch, Jan Kranich, Paul R Wratil, Johanna E Huber, Dirk Baumjohann, Simon Rothenfusser, Benjamin Schubert, Anne Hilgendorff, Johannes C Hellmuth, Clemens Scherer, Maximilian Muenchhoff, Michael von Bergwelt-Baildon, Konstantin Stark, Tobias Straub, Thomas Brocker, Oliver T Keppler, Marion Subklewe, Anne B Krug
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10, p e1009742 (2021)
Disease manifestations in COVID-19 range from mild to severe illness associated with a dysregulated innate immune response. Alterations in function and regeneration of dendritic cells (DCs) and monocytes may contribute to immunopathology and influenc
Externí odkaz:
https://doaj.org/article/852e03dd622546c7b68aaac8583d6fbd
Autor:
Rainer Kaiser, Alexander Leunig, Kami Pekayvaz, Oliver Popp, Markus Joppich, Vivien Polewka, Raphael Escaig, Afra Anjum, Marie-Louise Hoffknecht, Christoph Gold, Sophia Brambs, Anouk Engel, Sven Stockhausen, Viktoria Knottenberg, Anna Titova, Mohamed Haji, Clemens Scherer, Maximilian Muenchhoff, Johannes C. Hellmuth, Kathrin Saar, Benjamin Schubert, Anne Hilgendorff, Christian Schulz, Stefan Kääb, Ralf Zimmer, Norbert Hübner, Steffen Massberg, Philipp Mertins, Leo Nicolai, Konstantin Stark
Publikováno v:
JCI Insight, Vol 6, Iss 18 (2021)
Neutrophils provide a critical line of defense in immune responses to various pathogens, inflicting self-damage upon transition to a hyperactivated, procoagulant state. Recent work has highlighted proinflammatory neutrophil phenotypes contributing to
Externí odkaz:
https://doaj.org/article/6c76effe0be0417985fb0f08c49e4b8c
Autor:
David M. Cordas dos Santos, Lian Liu, Melvin Gerisch, Johannes C. Hellmuth, Michael von Bergwelt-Baildon, Wolfgang G. Kunz, Sebastian Theurich
Publikováno v:
Nutrients, Vol 14, Iss 20, p 4280 (2022)
Overweight and obesity are associated with chronic low-grade inflammation and represent risk factors for various diseases, including COVID-19. However, most published studies on COVID-19 defined obesity by the body mass index (BMI), which does not en
Externí odkaz:
https://doaj.org/article/8e9db7ec710d43888525f1ab790a2579
Autor:
Viktoria Florentine Koehler, Thomas Knösel, Sandra Elisabeth Hasmann, Clemens Scherer, Johannes C. Hellmuth, Maximilian Muenchhoff, Stefan Micheal Munker, Eva Hoster, Roland Ladurner, Christine Spitzweg
Publikováno v:
Thyroid. 33:177-185
Autor:
Ari M. Melnick, Martin Carroll, Ross L. Levine, Elisabeth M. Paietta, Caretha L. Creasy, Ryan G. Kruger, Gail J. Roboz, H. Leighton Grimes, David Muench, Monica L. Guzman, Martin S. Tallman, Omar Abdel-Wahab, Alan H. Shih, Kimberly N. Smitheman, Helai P. Mohammad, Johannes C. Hellmuth, Meng Li, Jacob L. Glass, Cem Meydan, Tak C. Lee, Francine E. Garrett-Bakelman, Matt Teater, Cihangir Duy
Supplementary Figures S1-S6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03aea8478ab5c1365cf9f64a733af523
https://doi.org/10.1158/2159-8290.22536274.v1
https://doi.org/10.1158/2159-8290.22536274.v1
Autor:
Ari M. Melnick, Martin Carroll, Ross L. Levine, Elisabeth M. Paietta, Caretha L. Creasy, Ryan G. Kruger, Gail J. Roboz, H. Leighton Grimes, David Muench, Monica L. Guzman, Martin S. Tallman, Omar Abdel-Wahab, Alan H. Shih, Kimberly N. Smitheman, Helai P. Mohammad, Johannes C. Hellmuth, Meng Li, Jacob L. Glass, Cem Meydan, Tak C. Lee, Francine E. Garrett-Bakelman, Matt Teater, Cihangir Duy
Frequency of recurrent mutations in the AML cohort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::859becb8853e4d22156e17e8ab94b622
https://doi.org/10.1158/2159-8290.22536268.v1
https://doi.org/10.1158/2159-8290.22536268.v1