Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Johannes Benedum"'
Autor:
Sylvia Kerschbaum-Gruber, Ava Kleinwächter, Katerina Popova, Alexandra Kneringer, Lisa-Marie Appel, Katharina Stasny, Anna Röhrer, Ana Beatriz Dias, Johannes Benedum, Lena Walch, Andreas Postl, Sandra Barna, Bernhard Kratzer, Winfried F. Pickl, Altuna Akalin, Filip Horvat, Vedran Franke, Joachim Widder, Dietmar Georg, Dea Slade
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionPancreatic ductal adenocarcinoma (PDAC) remains a leading cause of cancer-related deaths worldwide with limited treatment options due to extensive radiation and chemotherapy resistance. Monotherapy with immune checkpoint blockade showed n
Externí odkaz:
https://doaj.org/article/3025e223cab047d6828e139b1e21af01
Autor:
Johannes Benedum, Vedran Franke, Lisa-Marie Appel, Lena Walch, Melania Bruno, Rebecca Schneeweiss, Juliane Gruber, Helena Oberndorfer, Emma Frank, Xué Strobl, Anton Polyansky, Bojan Zagrovic, Altuna Akalin, Dea Slade
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Transcription is regulated by a multitude of activators and repressors, which bind to the RNA polymerase II (Pol II) machinery and modulate its progression. Death-inducer obliterator 3 (DIDO3) and PHD finger protein 3 (PHF3) are paralogue pr
Externí odkaz:
https://doaj.org/article/7e2958cf4ca145b5b98cf2019cfa7806
Autor:
Lisa-Marie Appel, Vedran Franke, Johannes Benedum, Irina Grishkovskaya, Xué Strobl, Anton Polyansky, Gregor Ammann, Sebastian Platzer, Andrea Neudolt, Anna Wunder, Lena Walch, Stefanie Kaiser, Bojan Zagrovic, Kristina Djinovic-Carugo, Altuna Akalin, Dea Slade
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Here the authors establish the SPOC domain as a universal reader of the RNA Pol II CTD code and a versatile reader of phosphoserine marks found in co- and post-transcriptional regulators such as m6A writer and reader proteins.
Externí odkaz:
https://doaj.org/article/c385ebe5d8ab489ea14decc0dad9379b
Autor:
Lisa-Marie Appel, Johannes Benedum, Magdalena Engl, Sebastian Platzer, Alexander Schleiffer, Xué Strobl, Dea Slade
Publikováno v:
Genes & Development. 37:140-170
Since it was first described >20 yr ago, the SPOC domain (Spen paralog and ortholog C-terminal domain) has been identified in many proteins all across eukaryotic species. SPOC-containing proteins regulate gene expression on various levels ranging fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20df419ae8de85294359e86eef1fcc92
https://doi.org/10.1101/gad.350314.122
https://doi.org/10.1101/gad.350314.122
Autor:
Lisa-Marie Appel, Irina Grishkovskaya, Johannes Benedum, Vedran Franke, Anton Polyansky, Andrea Neudolt, Anna Wunder, Bojan Zagrovic, Altuna Akalin, Kristina Djinovic-Carugo, Dea Slade
The heptarepeats of the C-terminal domain (CTD) of RNA polymerase II (Pol II) are extensively modified throughout the transcription cycle. The CTD coordinates RNA synthesis and processing by recruiting transcription regulation factors as well as RNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e731145958750e0e3031211f34d394fd
https://doi.org/10.1101/2022.02.26.482114
https://doi.org/10.1101/2022.02.26.482114
