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Autor:
Mark-Tilmann Seitz, Johannes Beismann, Heide Siggelkow, Martina Blaschke, Angelique Kragl, Regine Koepp, Frank Streit, Georg Manthey
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 210
11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1) plays an important role in pre-receptor glucocorticoid metabolism. This enzyme is expressed in bone, increases with age, and catalyzes the conversion of the inactive glucocorticoid cortisone into the ac