Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Johannes B Huppa"'
Autor:
Torsten Tonn, Hans Klingemann, Winfried S Wels, Jiri Eitler, Natalie Wotschel, Laurent Boissel, Michael Bachmann, Wiebke Rackwitz, Venugopal Gudipati, Nivedha Murali Shankar, Anastasia Sidorenkova, Johannes B Huppa, Paola Ortiz-Montero, Corinna Opitz, Stephan R Künzel, Susanne Michen, Achim Temme, Liliana Rodrigues Loureiro, Anja Feldmann
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 2 (2024)
Background The antitumor activity of natural killer (NK) cells can be enhanced by specific targeting with therapeutic antibodies that trigger antibody-dependent cell-mediated cytotoxicity (ADCC) or by genetic engineering to express chimeric antigen r
Externí odkaz:
https://doaj.org/article/635e8a9c7ed146e6934cedabb216012a
Autor:
Janett Göhring, Florian Kellner, Lukas Schrangl, René Platzer, Enrico Klotzsch, Hannes Stockinger, Johannes B. Huppa, Gerhard J. Schütz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Mechanical forces acting on ligand-engaged T-cell receptors (TCRs) have previously been implicated in T-cell antigen recognition, yet their sensitivity and specificity are still poorly defined. Here, authors report a FRET-based sensor that informs di
Externí odkaz:
https://doaj.org/article/9aaa195dbacc438b8940b42f235fb0e2
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Efficient scanning of tissue that T cells encounter during their migratory life is pivotal to protective adaptive immunity. In fact, T cells can detect even a single antigenic peptide/MHC complex (pMHC) among thousands of structurally similar yet non
Externí odkaz:
https://doaj.org/article/f1ba4d92a052403e9b4a4fc397e205ba
Autor:
René Platzer, Benedikt K. Rossboth, Magdalena C. Schneider, Eva Sevcsik, Florian Baumgart, Hannes Stockinger, Gerhard J. Schütz, Johannes B. Huppa, Mario Brameshuber
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Determining molecular clustering in Photoactivated Localization Microscopy (PALM) experiments requires knowledge of the blinking properties of the fluorophore to prevent overcounting artefacts. Here the authors develop an experimental and analytical
Externí odkaz:
https://doaj.org/article/d92f7a805d0a4aa697e8c1c2b9ffabca
Autor:
Benjamin Salzer, Christina M. Schueller, Charlotte U. Zajc, Timo Peters, Michael A. Schoeber, Boris Kovacic, Michelle C. Buri, Elisabeth Lobner, Omer Dushek, Johannes B. Huppa, Christian Obinger, Eva M. Putz, Wolfgang Holter, Michael W. Traxlmayr, Manfred Lehner
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The lack of tumour-specific antigens and control over T-cell activity limits the development of CAR-T cell therapies for solid tumours. Here the authors present an avidity-controlled CAR platform with inducible logic control functions.
Externí odkaz:
https://doaj.org/article/8783689044924d8ba5fdd958f3eeabd4
Autor:
Erika Garner-Spitzer, Angelika Wagner, Michael Kundi, Hannes Stockinger, Anna Ohradanova-Repic, Laura Gebetsberger, Anna-Margarita Schoetta, Venugopal Gudipati, Johannes B. Huppa, Renate Kunert, Patrick Mayrhofer, Thomas R. Kreil, Maria R. Farcet, Eva Hoeltl, Ursula Wiedermann
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
In a SARS-CoV-2 seroprevalence study conducted with 1,655 working adults in spring of 2020, 12 of the subjects presented with positive neutralization test (NT) titers (>1:10). They were here followed up for 1 year to assess their Ab persistence. We r
Externí odkaz:
https://doaj.org/article/b4ff2729839b47aca362fe1b6114797c
Autor:
Mark Smyth, Kseniya Khamina, Alexandra Popa, Venugopal Gudipati, Benedikt Agerer, Alexander Lercher, Lindsay Kosack, Lukas Endler, Hatoon Baazim, Csilla Viczenczova, Johannes B. Huppa, Andreas Bergthaler
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Cytotoxic T lymphocytes (CTLs) represent key immune effectors of the host response against chronic viruses, due to their cytotoxic response to virus-infected cells. In response to this selection pressure, viruses may accumulate escape mutations that
Externí odkaz:
https://doaj.org/article/189e3d41775e41b897b0e95c658d10e2
Autor:
Veronika Horkova, Ales Drobek, Darina Paprckova, Veronika Niederlova, Avishek Prasai, Valeria Uleri, Daniela Glatzova, Markus Kraller, Michaela Cesnekova, Sarka Janusova, Eva Salyova, Oksana Tsyklauri, Theresa A. Kadlecek, Katerina Krizova, René Platzer, Kilian Schober, Dirk H. Busch, Arthur Weiss, Johannes B. Huppa, Ondrej Stepanek
Publikováno v:
Nature Immunology. 24:174-185
The kinase LCK and CD4/CD8 co-receptors are crucial components of the T cell antigen receptor (TCR) signaling machinery, leading to key T cell fate decisions. Despite decades of research, the roles of CD4–LCK and CD8–LCK interactions in TCR trigg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::558e5771858f2dd70484f422099c8b4e
https://doi.org/10.1038/s41590-022-01366-0
https://doi.org/10.1038/s41590-022-01366-0
Autor:
Elisabeth Lobner, Anna Wachernig, Venugopal Gudipati, Patrick Mayrhofer, Benjamin Salzer, Manfred Lehner, Johannes B. Huppa, Renate Kunert
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
The transmembrane protein CD19 is exclusively expressed on normal and malignant B cells and therefore constitutes the target of approved CAR-T cell-based cancer immunotherapies. Current efforts to assess CAR-T cell functionality in a quantitative fas
Externí odkaz:
https://doaj.org/article/0f365f4fccb444509b2ae58a3233f0cf
Autor:
Anthea Wirges, Mario Bunse, Jara J. Joedicke, Eric Blanc, Venugopal Gudipati, Michael W. Moles, Hiroshi Shiku, Dieter Beule, Johannes B. Huppa, Uta E. Höpken, Armin Rehm
Publikováno v:
Molecular Therapy. 30:3358-3378
Chimeric antigen receptor (CAR) T cells have revolutionized treatment of B cell malignancies. However, enhancing the efficacy of engineered T cells without compromising their safety is warranted. The estrogen receptor-binding fragment-associated anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf8f3cde4606133d57bf5b7f34934ef
https://doi.org/10.1016/j.ymthe.2022.07.009
https://doi.org/10.1016/j.ymthe.2022.07.009