Zobrazeno 1 - 10
of 9 281
pro vyhledávání: '"Johannes B"'
Autor:
Daniel L. van den Kroonenberg, Auke Jager, Anna Garrido-Utrilla, Johannes B. Reitsma, Arnoud W. Postema, Harrie P. Beerlage, Jorg R. Oddens
Publikováno v:
European Urology Open Science, Vol 66, Iss , Pp 60-66 (2024)
We present the protocol for a study testing the hypothesis that a computer-aided diagnosis (CAD) system for three-dimensional multiparametric ultrasound (3D mpUS) is noninferior to magnetic resonance imaging (MRI) in guiding prostate biopsies for det
Externí odkaz:
https://doaj.org/article/e1036b0af8ba4d59a470702f98f68af6
Autor:
Haressh Sajiir, Sahar Keshvari, Kuan Yau Wong, Danielle J. Borg, Frederik J. Steyn, Christian Fercher, Karin Taylor, Breten Taylor, Ross T. Barnard, Alexandra Müller, Md Moniruzzaman, Gregory Miller, Ran Wang, Amelia Fotheringham, Veronika Schreiber, Yong Hua Sheng, Janelle Louise Hancock, Dorothy Loo, Lucy Burr, Tony Huynh, Jack Lockett, Grant A. Ramm, Graeme A. Macdonald, Johannes B. Prins, Michael A. McGuckin, Sumaira Z. Hasnain
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Metabolic dysfunction-associated steatohepatitis (MASH) is the most prevalent cause of liver disease worldwide, with a single approved therapeutic. Previous research has shown that interleukin-22 (IL-22) can suppress β-cell stress, reduce l
Externí odkaz:
https://doaj.org/article/5c697ee738e34e89bcba2d1629c34f97
Autor:
Haressh Sajiir, Kuan Yau Wong, Alexandra Müller, Sahar Keshvari, Lucy Burr, Elena Aiello, Teresa Mezza, Andrea Giaccari, Guido Sebastiani, Francesco Dotta, Grant A. Ramm, Graeme A. Macdonald, Michael A. McGuckin, Johannes B. Prins, Sumaira Z. Hasnain
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The IL-22RA1 receptor is highly expressed in the pancreas, and exogenous IL-22 has been shown to reduce endoplasmic reticulum and oxidative stress in human pancreatic islets and promote secretion of high-quality insulin from beta-cells. Howe
Externí odkaz:
https://doaj.org/article/2dd7271812bb4bb1928d16716fbb7ba1
Autor:
Irene Andreu-Saumell, Alba Rodriguez-Garcia, Vanessa Mühlgrabner, Marta Gimenez-Alejandre, Berta Marzal, Joan Castellsagué, Fara Brasó-Maristany, Hugo Calderon, Laura Angelats, Salut Colell, Mara Nuding, Marta Soria-Castellano, Paula Barbao, Aleix Prat, Alvaro Urbano-Ispizua, Johannes B. Huppa, Sonia Guedan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Chimeric antigen receptor (CAR)-T cell therapy for solid tumors faces significant hurdles, including T-cell inhibition mediated by the PD-1/PD-L1 axis. The effects of disrupting this pathway on T-cells are being actively explored and controv
Externí odkaz:
https://doaj.org/article/7804df0598d54b5bb293efc2b4f633cf
Publikováno v:
Stress, Vol 27, Iss 1 (2024)
AbstractThe cold pressor test (CPT) elicits strong cardiovascular reactions via activation of the sympathetic nervous system (SNS), yielding subsequent increases in heart rate (HR) and blood pressure (BP). However, little is known on how exposure to
Externí odkaz:
https://doaj.org/article/3004922b8482496b9564c11774be59c9
Autor:
Ashwathi Puravankara Menon, Helena Villanueva, Daniel Meraviglia-Crivelli, Hisse M. van Santen, Joschka Hellmeier, Angelina Zheleva, Francesca Nonateli, Timo Peters, Tassilo L.A. Wachsmann, Mercedes Hernandez-Rueda, Johannes B. Huppa, Gerhard J. Schütz, Eva Sevcsik, Beatriz Moreno, Fernando Pastor
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102198- (2024)
The CD3/T cell receptor (TCR) complex is responsible for antigen-specific pathogen recognition by T cells, and initiates the signaling cascade necessary for activation of effector functions. CD3 agonistic antibodies are commonly used to expand T lymp
Externí odkaz:
https://doaj.org/article/6c3ef753dfa94901b0ef2480454cb96e
Autor:
Michael W. Moles, Henry Erdlei, Lutz Menzel, Marialucia Massaro, Agnese Fiori, Mario Bunse, Moritz Schrimpf, Kerstin Gerlach, Venugopal Gudipati, John Reiser, Ketan Mathavan, Jodie P. Goodrich, Johannes B. Huppa, Jan Krönke, Bahram Valamehr, Uta E. Höpken, Armin Rehm
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Multiple myeloma (MM) is a plasma cell disease with a preferential bone marrow (BM) tropism. Enforced expression of tissue-specific chemokine receptors has been shown to successfully guide adoptively-transferred CAR NK cells towards the malignant mil
Externí odkaz:
https://doaj.org/article/2dd8f8910e9849f68e43bc637bdeee21
Publikováno v:
BMC Medical Education, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background Assessing trainees is crucial for development of their competence, yet it remains a challenging endeavour. Identifying contributing and influencing factors affecting this process is imperative for improvement. Methods We surveyed
Externí odkaz:
https://doaj.org/article/a4ed1fc2319c432ca568d51eadce962c
Autor:
Richard F. Silver, Mei Xia, Chad E. Storer, Jessica R. Jarvela, Michelle C. Moyer, Azra Blazevic, David A. Stoeckel, Erin K. Rakey, Jan M. Tennant, Johannes B. Goll, Richard D. Head, Daniel F. Hoft
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Tuberculosis remains an international health threat partly because of limited protection from pulmonary tuberculosis provided by standard intradermal vaccination with Bacillus of Calmette and Guérin (BCG); this may reflect the inability of
Externí odkaz:
https://doaj.org/article/f8f84a0fa65143f59a7acea80e7cee39
Autor:
Amit Frishberg, Neta Milman, Ayelet Alpert, Hannah Spitzer, Ben Asani, Johannes B. Schiefelbein, Evgeny Bakin, Karen Regev-Berman, Siegfried G. Priglinger, Joachim L. Schultze, Fabian J. Theis, Shai S. Shen-Orr
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Diseases change over time, both phenotypically and in their underlying molecular processes. Though understanding disease progression dynamics is critical for diagnostics and treatment, capturing these dynamics is difficult due to their compl
Externí odkaz:
https://doaj.org/article/bd7fa885149a45ffa2a623393e803d3b