Zobrazeno 1 - 10
of 220
pro vyhledávání: '"Johannes A, Eble"'
Autor:
Mari Palviainen, Johanna Puutio, Rikke Halse Østergaard, Johannes A. Eble, Katariina Maaninka, Umar Butt, Joseph Ndika, Otto K. Kari, Masood Kamali‐Moghaddam, Kasper Kjaer‐Sorensen, Claus Oxvig, Ana M. Aransay, Juan M. Falcon‐Perez, Antonio Federico, Dario Greco, Saara Laitinen, Yuya Hayashi, Pia R.‐M. Siljander
Publikováno v:
Journal of Extracellular Vesicles, Vol 13, Iss 10, Pp n/a-n/a (2024)
Abstract Renowned for their role in haemostasis and thrombosis, platelets are also increasingly recognized for their contribution in innate immunity, immunothrombosis and inflammatory diseases. Platelets express a wide range of receptors, which allow
Externí odkaz:
https://doaj.org/article/d1bacf0104064fd49990f7e4e0293c8c
Autor:
Katrin Brockhaus, Isabel Hemsen, Saskia-Larissa Jauch-Speer, Stephan Niland, Thomas Vogl, Johannes A. Eble
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
IntroductionOsteoclasts determine bone tissue turnover. Their increased activity causes osteoporosis, their dysfunction osteopetrosis.Methods and ResultsMurine monocytic ER-Hoxb8 cells differentiate into OCs upon treatment with M-CSF and RANKL and up
Externí odkaz:
https://doaj.org/article/9c6ccbee248248e183bb79b6ccfd7d25
Autor:
Brice Nzigou Mombo, Brent M. Bijonowski, Christopher A. Raab, Stephan Niland, Katrin Brockhaus, Marc Müller, Johannes A. Eble, Seraphine V. Wegner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract E-cadherin-based cell-cell adhesions are dynamically and locally regulated in many essential processes, including embryogenesis, wound healing and tissue organization, with dysregulation manifesting as tumorigenesis and metastasis. However,
Externí odkaz:
https://doaj.org/article/95180b5c11be448fa2645bf8fa403228
Autor:
Emily Hoffmann, Daniel Schache, Carsten Höltke, Jens Soltwisch, Stephan Niland, Tobias Krähling, Klaus Bergander, Martin Grewer, Christiane Geyer, Linda Groeneweg, Johannes A. Eble, Thomas Vogl, Johannes Roth, Walter Heindel, Bastian Maus, Anne Helfen, Cornelius Faber, Moritz Wildgruber, Mirjam Gerwing, Verena Hoerr
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background With metabolic alterations of the tumor microenvironment (TME) contributing to cancer progression, metastatic spread and response to targeted therapies, non-invasive and repetitive imaging of tumor metabolism is of major importanc
Externí odkaz:
https://doaj.org/article/76432bd0b33048e585ea50f788f241f8
Autor:
Joanne C. Clark, Eleyna M. Martin, Luis A. Morán, Ying Di, Xueqing Wang, Malou Zuidscherwoude, Helena C. Brown, Deirdre M. Kavanagh, Johan Hummert, Johannes A. Eble, Bernhard Nieswandt, David Stegner, Alice Y. Pollitt, Dirk-Peter Herten, Michael G. Tomlinson, Angel García, Steve P. Watson
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
Fluorescence correlation spectroscopy on crosslinked nanobodies tested on C-type lectin-like receptor 2 (CLEC-2) show different outcomes for divalent and tetravalent nanobody ligands on CLEC-2 clustering, also dependent on CLEC-2 expression levels.
Externí odkaz:
https://doaj.org/article/7459f6954fe94e3e8043691e4c0d8e5b
Autor:
Majdi Saleem Naamneh, Tatjana Momic, Michal Klazas, Julius Grosche, Johannes A. Eble, Cezary Marcinkiewicz, Netaly Khazanov, Hanoch Senderowitz, Amnon Hoffman, Chaim Gilon, Jehoshua Katzhendler, Philip Lazarovici
Publikováno v:
Pharmaceuticals, Vol 17, Iss 5, p 549 (2024)
To develop peptide drugs targeting integrin receptors, synthetic peptide ligands endowed with well-defined selective binding motifs are necessary. The snake venom KTS-containing disintegrins, which selectively block collagen α1β1 integrin, were use
Externí odkaz:
https://doaj.org/article/a2507c50643f46cfb8943819957681cd
Autor:
Silke Niemann, Minh-Thu Nguyen, Johannes A. Eble, Achmet I. Chasan, Maria Mrakovcic, Klaus T. Preissner, Steffen Roßlenbroich, Georg Peters, Mathias Herrmann
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
Externí odkaz:
https://doaj.org/article/2279771809c547608f85c21fca8038e6
Autor:
Marleen Leidecker, Anne Bertling, Muzaffar Hussain, Markus Bischoff, Johannes A. Eble, Anke C. Fender, Kerstin Jurk, Christine Rumpf, Mathias Herrmann, Beate E. Kehrel, Silke Niemann
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Invasion of host cells is an important feature of Staphylococcus aureus. The main internalization pathway involves binding of the bacteria to host cells, e.g., endothelial cells, via a fibronectin (Fn) bridge between S. aureus Fn binding pro
Externí odkaz:
https://doaj.org/article/73e69fcca14b4482af13cb2f5dceb691
Autor:
Thomas Vogl, Moritz Wildgruber, Cornelius Faber, Emily Hoffmann, Mirjam Gerwing, Stephan Niland, Rolf Niehoff, Max Masthoff, Christiane Geyer, Lydia Wachsmuth, Enrica Wilken, Carsten Höltke, Walter L Heindel, Verena Hoerr, Regina Schinner, Philipp Berger, Johannes A Eble, Bastian Maus, Anne Helfen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 3 (2023)
Background The inflammatory tumor microenvironment (TME) is formed by various immune cells, being closely associated with tumorigenesis. Especially, the interaction between tumor-infiltrating T-cells and macrophages has a crucial impact on tumor prog
Externí odkaz:
https://doaj.org/article/e0037d62af4746e08616a8d85ec2720a
Autor:
Bibian M.E. Tullemans, Mieke F.A. Karel, Valentine Léopold, Marieke S. ten Brink, Constance C.F.M.J. Baaten, Sanne L. Maas, Alex F. deVos, Johannes A. Eble, Marten R. Nijziel, Emiel P.C. van derVorst, Judith M.E.M. Cosemans, Johan W.M. Heemskerk, Theodora A.M. Claushuis, Marijke J.E. Kuijpers
Publikováno v:
eJHaem, Vol 2, Iss 4, Pp 685-699 (2021)
Abstract All irreversible Bruton tyrosine kinase (Btk) inhibitors including ibrutinib and acalabrutinib induce platelet dysfunction and increased bleeding risk. New reversible Btk inhibitors were developed, like MK‐1026. The mechanism underlying in
Externí odkaz:
https://doaj.org/article/44007a92296c4e6e8eb464bf7bca834a