Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Johannes, Winkler"'
Autor:
Dominika Lukovic, Ena Hasimbegovic, Johannes Winkler, Julia Mester-Tonczar, Katrin Müller-Zlabinger, Emilie Han, Andreas Spannbauer, Denise Traxler-Weidenauer, Jutta Bergler-Klein, Noemi Pavo, Georg Goliasch, Sandor Batkai, Thomas Thum, Faiez Zannad, Mariann Gyöngyösi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7461 (2023)
We have designed translational animal models to investigate cardiac profibrotic gene signatures. Domestic pigs were treated with cardiotoxic drugs (doxorubicin, DOX, n = 5 or Myocet®, MYO, n = 5) to induce replacement fibrosis via cardiotoxicity. Re
Externí odkaz:
https://doaj.org/article/96e9f9621bfb4daba2689ff6da6ae936
Autor:
Edit Gara, Sang-Ging Ong, Johannes Winkler, Katrin Zlabinger, Dominika Lukovic, Bela Merkely, Maximilian Y. Emmert, Petra Wolint, Simon P. Hoerstrup, Mariann Gyöngyösi, Joseph C. Wu, Noemi Pavo
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Recent preclinical investigations and clinical trials with stem cells mostly studied bone-marrow-derived mononuclear cells (BM-MNCs), which so far failed to meet clinically significant functional study endpoints. BM-MNCs containing small proportions
Externí odkaz:
https://doaj.org/article/70555f8610974d02a82f41484bd3bc49
Autor:
Johannes Winkler, Dominika Lukovic, Julia Mester-Tonczar, Katrin Zlabinger, Alfred Gugerell, Noemi Pavo, András Jakab, Zsuzsanna Szankai, Denise Traxler, Claudia Müller, Andreas Spannbauer, Martin Riesenhuber, Ena Hašimbegović, James Dawkins, Matthias Zimmermann, Hendrik J. Ankersmit, Eduardo Marbán, Mariann Gyöngyösi
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 354-366 (2020)
Cardiosphere-derived cells (CDCs) are progenitor cells derived from heart tissue and have shown promising results in preclinical models. APOSEC, the secretome of irradiated peripheral blood mononuclear cells, has decreased infarct size in acute and c
Externí odkaz:
https://doaj.org/article/8fb9d32870534bee944827176257791e
Autor:
Ariana Foinquinos, Sandor Batkai, Celina Genschel, Janika Viereck, Steffen Rump, Mariann Gyöngyösi, Denise Traxler, Martin Riesenhuber, Andreas Spannbauer, Dominika Lukovic, Natalie Weber, Katrin Zlabinger, Ena Hašimbegović, Johannes Winkler, Jan Fiedler, Seema Dangwal, Martin Fischer, Jeanne de la Roche, Daniel Wojciechowski, Theresia Kraft, Rita Garamvölgyi, Sonja Neitzel, Shambhabi Chatterjee, Xiaoke Yin, Christian Bär, Manuel Mayr, Ke Xiao, Thomas Thum
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
miR-132 was shown to drive pathological cardiac remodeling, a hallmark of heart failure. Here, the authors show that an antisense inhibitor of miR-132 has favourable pharmacokinetics, safety-tolerability and preclinical efficacy in mouse and porcine
Externí odkaz:
https://doaj.org/article/33579ddb7f504de8ad9792e4fd12c4d2
Autor:
Nina Kastner, Julia Mester-Tonczar, Johannes Winkler, Denise Traxler, Andreas Spannbauer, Beate M. Rüger, Georg Goliasch, Noemi Pavo, Mariann Gyöngyösi, Katrin Zlabinger
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
IntroductionDespite major leaps in regenerative medicine, the regeneration of cardiomyocytes after ischemic conditions remains to elucidate. It is crucial to understand hypoxia induced cellular mechanisms to provide advanced treatment options, includ
Externí odkaz:
https://doaj.org/article/79685fd8ed864589baea4244251209aa
Autor:
Mariann Gyöngyösi, Noemi Pavo, Dominika Lukovic, Katrin Zlabinger, Andreas Spannbauer, Denise Traxler, Georg Goliasch, Ljubica Mandic, Jutta Bergler-Klein, Alfred Gugerell, Andras Jakab, Zsuzsanna Szankai, Levente Toth, Rita Garamvölgyi, Gerald Maurer, Frederic Jaisser, Faiez Zannad, Thomas Thum, Sándor Bátkai, Johannes Winkler
Publikováno v:
Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-15 (2017)
Abstract Background Meaningful translational large animal models for cardiac diseases are indispensable for studying disease mechanisms, development of novel therapeutic strategies, and evaluation of potential drugs. Methods For induction of heart fa
Externí odkaz:
https://doaj.org/article/e9011016638048b8a2c017f7acbe8f45
Supplementary Data from EpCAM-targeted delivery of nanocomplexed siRNA to tumor cells with designed ankyrin repeat proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1ebbb56ef666705e35a19ac5b07b79
https://doi.org/10.1158/1535-7163.22485132.v1
https://doi.org/10.1158/1535-7163.22485132.v1
Specific delivery to tumors and efficient cellular uptake of nucleic acids remain major challenges for gene-targeted cancer therapies. Here we report the use of a designed ankyrin repeat protein (DARPin) specific for the epithelial cell adhesion mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4aca48e2aa99f456a41fda1c04e52e
https://doi.org/10.1158/1535-7163.c.6531792
https://doi.org/10.1158/1535-7163.c.6531792
Autor:
Julia Mester-Tonczar, Patrick Einzinger, Johannes Winkler, Nina Kastner, Andreas Spannbauer, Katrin Zlabinger, Denise Traxler, Dominika Lukovic, Ena Hasimbegovic, Georg Goliasch, Noemi Pavo, Mariann Gyöngyösi
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1390 (2021)
Circular RNAs (circRNAs) are crucial in gene regulatory networks and disease development, yet circRNA expression in myocardial infarction (MI) is poorly understood. Here, we harvested myocardium samples from domestic pigs 3 days after closed-chest re
Externí odkaz:
https://doaj.org/article/d49253552e204667a99fd7387e0a79c9
Autor:
Julia Mester-Tonczar, Johannes Winkler, Patrick Einzinger, Ena Hasimbegovic, Nina Kastner, Dominika Lukovic, Katrin Zlabinger, Andreas Spannbauer, Denise Traxler, Sandor Batkai, Thomas Thum, Mariann Gyöngyösi
Publikováno v:
Biomolecules, Vol 10, Iss 8, p 1180 (2020)
Anti-fibrotic therapies are of increasing interest to combat cardiac remodeling and heart failure progression. Recently, anti-fibrotic circular RNAs (circRNAs) have been identified in human and rodent cardiac tissue. In vivo (rodent) experiments prov
Externí odkaz:
https://doaj.org/article/6053f1c4f13a4385887f65779b510cbc