Výsledky vyhledávání - "Johannes, Wedel"

Abstract 3866: Targeting AXL can effectively inhibit c-Met-induced therapeutic resistance in renal cancer

Autor: Akash Sabarwal, Laxminarayan Rawat, Johannes Wedel, Yuzuru Sasamoto, Sabina Signoretti, Toni K. Choueiri, Murugabaskar Balan, Soumitro Pal

Publikováno v: Cancer Research. 83:3866-3866

Advanced stage renal cell carcinoma (RCC) often becomes resistant to the currently available therapeutic options. Receptor Tyrosine Kinase (RTK), c-Met, is overexpressed and hyperactivated in renal cancer; and it promotes tumor-promoting pathways fol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c090f6d2aaa27a13cad4082db54eadb
https://doi.org/10.1158/1538-7445.am2023-3866

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A Combination therapy using an mTOR inhibitor and Honokiol effectively induces autophagy through the modulation of AXL and Rubicon in renal cancer cells and restricts renal tumor growth following organ transplantation

Autor: Akash Sabarwal, Johannes Wedel, Kaifeng Liu, David Zurakowski, Samik Chakraborty, Evelyn Flynn, David M Briscoe, Murugabaskar Balan, Soumitro Pal

Publikováno v: Carcinogenesis

Development of cancer, including renal cancer, is a major problem in immunosuppressed patients. The mTOR inhibitor Rapamycin (RAPA) is used as an immunosuppressive agent in patients with organ transplants and other immunological disorders; and it als

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91cde526fc364383acb4ae0372d37ba3
https://europepmc.org/articles/PMC9118982/

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Inhibition of mevalonate metabolism by statins augments the immunoregulatory phenotype of vascular endothelial cells and inhibits the costimulation of CD4

Autor: Sek Wong Kong, Daniel Goodman, David M. Briscoe, Johannes Wedel, Sayantan Bose, Timna Agur, A.G. Pramoda Sahankumari, Chandra C. Ghosh

Publikováno v: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsREFERENCES. 22(3)

The statin family of therapeutics is widely used clinically as cholesterol lowering agents, and their effects to target intracellular mevalonate production is a key mechanism of action. In this study, we performed full transcriptomic RNA sequencing a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01231ca93c0caaa7a4e8c0f4e1ef68d7
https://pubmed.ncbi.nlm.nih.gov/34687147

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T Cell–Specific Adaptor Protein Regulates Mitochondrial Function and CD4+ T Regulatory Cell Activity In Vivo following Transplantation

Autor: Kaifeng Liu, Johannes Wedel, David M. Briscoe, Evelyn Flynn, Isaac E. Stillman, Tatsuichiro Seto, Maria P. Stack, Matthew M. Sheehan, Sek Won Kong

Publikováno v: The Journal of Immunology. 203:2328-2338

The T cell–specific adaptor protein (TSAd), encoded by the SH2D2A gene, is an intracellular molecule that binds Lck to elicit signals that result in cytokine production in CD4+ T effector cells (Teff). Nevertheless, using Sh2d2a knockout (KO; also

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https://doi.org/10.4049/jimmunol.1801604

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Treatment with 2,4-Dihydroxybenzoic Acid Prevents FSGS Progression and Renal Fibrosis in Podocyte-Specific Coq6 Knockout Mice

Autor: Makiko Nakayama, Johannes Wedel, Eugen Widmeier, Merlin Airik, Anish Nag, Catherine F. Clarke, Hannah Hugo, Rannar Airik, Jang Cho, Ronen Schneider, Markus Schueler, David Schapiro, Friedhelm Hildebrandt, Chandra C. Ghosh, Agape M. Awad

Publikováno v: Journal of the American Society of Nephrology. 30:393-405

Background Although studies have identified >55 genes as causing steroid-resistant nephrotic syndrome (SRNS) and localized its pathogenesis to glomerular podocytes, the disease mechanisms of SRNS remain largely enigmatic. We recently reported that in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e187d4bc474e38b49c2ffe1fc453489
https://doi.org/10.1681/asn.2018060625

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Akademický článek

N-octanoyl dopamine treatment of endothelial cells induces the unfolded protein response and results in hypometabolism and tolerance to hypothermia.

Autor: Eleni Stamellou, Johann Fontana, Johannes Wedel, Emmanouil Ntasis, Carsten Sticht, Anja Becker, Prama Pallavi, Kerstin Wolf, Bernhard K Krämer, Mathias Hafner, Willem J van Son, Benito A Yard

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e99298 (2014)

N-acyl dopamines (NADD) are gaining attention in the field of inflammatory and neurological disorders. Due to their hydrophobicity, NADD may have access to the endoplasmic reticulum (ER). We therefore investigated if NADD induce the unfolded protein

Externí odkaz: https://doaj.org/article/2728dad1171b4a3682aca89dcf18cfcf

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Akademický článek

N-octanoyl dopamine inhibits the expression of a subset of κB regulated genes: potential role of p65 Ser276 phosphorylation.

Autor: Maximilia C Hottenrott, Johannes Wedel, Sophie Gaertner, Eleni Stamellou, Tineke Kraaij, Linda Mandel, Ralf Loesel, Carsten Sticht, Simone Hoeger, Lamia Ait-Hsiko, Angelika Schedel, Mathias Hafner, Benito Yard, Charalambos Tsagogiorgas

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e73122 (2013)

Background and purposeCatechol containing compounds have anti-inflammatory properties, yet for catecholamines these properties are modest. Since we have previously demonstrated that the synthetic dopamine derivative N-octanoyl dopamine (NOD) has supe

Externí odkaz: https://doaj.org/article/65788b7d3f5d42a0b68082d001b8a47a

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Akademický článek

N-octanoyl-dopamine is an agonist at the capsaicin receptor TRPV1 and mitigates ischemia-induced [corrected] acute kidney injury in rat.

Autor: Charalambos Tsagogiorgas, Johannes Wedel, Maximilia Hottenrott, Michael O Schneider, Uta Binzen, Wolfgang Greffrath, Rolf-Detlef Treede, Bastian Theisinger, Sonja Theisinger, Rüdiger Waldherr, Bernhard K Krämer, Manfred Thiel, Peter Schnuelle, Benito A Yard, Simone Hoeger

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e43525 (2012)

Since stimulation of transient receptor potential channels of the vanilloid receptor subtype 1 (TRPV1) mitigates acute kidney injury (AKI) and endogenous N-acyl dopamine derivatives are able to activate TRPV1, we tested if synthetic N-octanoyl-dopami

Externí odkaz: https://doaj.org/article/b3fd39bb2d0146e4bf4a838d722eda7d

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The intragraft microenvironment as a central determinant of chronic rejection or local immunoregulation/tolerance

Autor: David M. Briscoe, Josephine Koch, Diane R. Bielenberg, Nora Kochupurakkal, Hironao Nakayama, Johannes Wedel, Michael Klagsbrun

Publikováno v: Current Opinion in Organ Transplantation. 22:55-63

Purpose of review Chronic rejection is associated with persistent mononuclear cell recruitment, endothelial activation and proliferation, local tissue hypoxia and related biology that enhance effector immune responses. In contrast, the tumor microenv

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https://doi.org/10.1097/mot.0000000000000373

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