Zobrazeno 1 - 10
of 332
pro vyhledávání: '"Johannes, Kirchmair"'
Autor:
Fabian Giehler, Michael S. Ostertag, Thomas Sommermann, Daniel Weidl, Kai R. Sterz, Helmut Kutz, Andreas Moosmann, Stephan M. Feller, Arie Geerlof, Brigitte Biesinger, Grzegorz M. Popowicz, Johannes Kirchmair, Arnd Kieser
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) drives viral B cell transformation and oncogenesis. LMP1’s transforming activity depends on its C-terminal activation region 2 (CTAR2), which induces NF-κB and JNK by engaging TNF
Externí odkaz:
https://doaj.org/article/6129e63ef175431f88dcfe4bca0f1328
Autor:
Vincenzo Palmacci, Steffen Hirte, Jorge Enrique Hernández González, Floriane Montanari, Johannes Kirchmair
Publikováno v:
Artificial Intelligence in the Life Sciences, Vol 5, Iss , Pp 100099- (2024)
High throughput screening (HTS) technologies allow the biological testing of hundreds of thousands of compounds per day. Typically, a substantial proportion of the initial hits obtained by HTS are artifacts caused by assay interference. Therefore, gl
Externí odkaz:
https://doaj.org/article/c09d82e891d14583a42d03d919ea9a5e
Autor:
Valeria Iobbi, Giuliana Donadio, Anna Paola Lanteri, Norbert Maggi, Johannes Kirchmair, Valentina Parisi, Giovanni Minuto, Andrea Copetta, Mauro Giacomini, Angela Bisio, Nunziatina De Tommasi, Giuliana Drava
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
IntroductionThe development of agriculture in terms of sustainability and low environmental impact is, at present, a great challenge, mainly in underdeveloped and marginal geographical areas. The Salvia rosmarinus “Eretto Liguria” ecotype is wide
Externí odkaz:
https://doaj.org/article/bb330c3c39014432b4181ae0b29fb027
Autor:
Karla Gonzalez-Ponce, Carolina Horta Andrade, Fiona Hunter, Johannes Kirchmair, Karina Martinez-Mayorga, José L. Medina-Franco, Matthias Rarey, Alexander Tropsha, Alexandre Varnek, Barbara Zdrazil
Publikováno v:
Journal of Cheminformatics, Vol 15, Iss 1, Pp 1-8 (2023)
Abstract We report the major highlights of the School of Cheminformatics in Latin America, Mexico City, November 24–25, 2022. Six lectures, one workshop, and one roundtable with four editors were presented during an online public event with speaker
Externí odkaz:
https://doaj.org/article/c9a69d2acfea4f7f825f83006b877516
Autor:
Jürgen Bajorath, Steve Gardner, Francesca Grisoni, Carolina Horta Andrade, Johannes Kirchmair, Melissa Landon, José L. Medina-Franco, Filip Miljković, Floriane Montantari, Raquel Rodríguez-Pérez
Publikováno v:
Artificial Intelligence in the Life Sciences, Vol 4, Iss , Pp 100088- (2023)
Externí odkaz:
https://doaj.org/article/1f45f11c49974156a8e5aacbd3647dc9
Autor:
Wenjie Xue, Yaling Wang, Xu Lian, Xueyao Li, Jing Pang, Johannes Kirchmair, Kebin Wu, Zunsheng Han, Xuefu You, Hongmin Zhang, Jie Xia, Song Wu
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1620-1631 (2022)
Emerging drug resistance is generating an urgent need for novel and effective antibiotics. A promising target that has not yet been addressed by approved antibiotics is the bacterial DNA gyrase subunit B (GyrB), and GyrB inhibitors could be effective
Externí odkaz:
https://doaj.org/article/65d67e69c852493f8927843607a0ecb4
Autor:
Andrea Morger, Marina Garcia de Lomana, Ulf Norinder, Fredrik Svensson, Johannes Kirchmair, Miriam Mathea, Andrea Volkamer
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Machine learning models are widely applied to predict molecular properties or the biological activity of small molecules on a specific protein. Models can be integrated in a conformal prediction (CP) framework which adds a calibration step t
Externí odkaz:
https://doaj.org/article/9640412f156b4083ba647cd502b86051
Autor:
Fidele Ntie-Kang, Kiran K. Telukunta, Serge A. T. Fobofou, Victor Chukwudi Osamor, Samuel A. Egieyeh, Marilia Valli, Yannick Djoumbou-Feunang, Maria Sorokina, Conrad Stork, Neann Mathai, Paul Zierep, Ana L. Chávez-Hernández, Miquel Duran-Frigola, Smith B. Babiaka, Romuald Tematio Fouedjou, Donatus B. Eni, Simeon Akame, Augustine B. Arreyetta-Bawak, Oyere T. Ebob, Jonathan A. Metuge, Boris D. Bekono, Mustafa A. Isa, Raphael Onuku, Daniel M. Shadrack, Thommas M. Musyoka, Vaishali M. Patil, Justin J. J. van der Hooft, Vanderlan da Silva Bolzani, José L. Medina-Franco, Johannes Kirchmair, Tilmann Weber, Özlem Tastan Bishop, Marnix H. Medema, Ludger A. Wessjohann, Jutta Ludwig-Müller
Publikováno v:
Journal of Cheminformatics, Vol 13, Iss 1, Pp 1-11 (2021)
Abstract We report the major conclusions of the online open-access workshop “Computational Applications in Secondary Metabolite Discovery (CAiSMD)” that took place from 08 to 10 March 2021. Invited speakers from academia and industry and about 20
Externí odkaz:
https://doaj.org/article/dc580d833d694863bc03b9de2b1575e5
Autor:
Thies Ingwersen, Christian Linnenberg, Emanuela D’Acunto, Shabnam Temori, Irene Paolucci, David Wasilewski, Behnam Mohammadi, Johannes Kirchmair, Robert C. Glen, Elena Miranda, Markus Glatzel, Giovanna Galliciotti
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Familial encephalopathy with neuroserpin inclusion bodies (FENIB) is a progressive neurodegenerative disease caused by point mutations in the gene for neuroserpin, a serine protease inhibitor of the nervous system. Different mutations are kn
Externí odkaz:
https://doaj.org/article/82d3602c215e4fa28f209ae781dcc486
Autor:
Lars Olsen
Publikováno v:
ChemMedChem. 11:144-144