Výsledky vyhledávání - "Johannes, Heemskerk"

Phase I Trial of 131I-GMIB-Anti-HER2-VHH1, a New Promising Candidate for HER2-Targeted Radionuclide Therapy in Breast Cancer Patients

Autor: Marleen Keyaerts, Frank van der Aa, Ilse Vaneycken, Matthias D'Huyvetter, Tony Lahoutte, Hendrik Everaert, Albert D. Windhorst, Vicky Caveliers, Nick Devoogdt, Pieterjan Gykiere, Geert Raes, N. Harry Hendrikse, Jens De Vos, Jos L E Eersels, Johannes Heemskerk, Christel Fontaine, Marian Vanhoeij, François Duhoux

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 62(8), 1097-1105
D'Huyvetter, M, Vos, J D, Caveliers, V, Vaneycken, I, Heemskerk, J, Duhoux, F P, Fontaine, C, Vanhoeij, M, Windhorst, A D, Aa, F V D, Hendrikse, N H, Eersels, J L E, Everaert, H, Gykiere, P, Devoogdt, N, Raes, G, Lahoutte, T & Keyaerts, M 2021, ' Phase I Trial of 131I-GMIB-Anti-HER2-VHH1, a New Promising Candidate for HER2-Targeted Radionuclide Therapy in Breast Cancer Patients ', Journal of nuclear medicine : official publication, Society of Nuclear Medicine, vol. 62, no. 8, pp. 1097-1105 . https://doi.org/10.2967/jnumed.120.255679

Introduction:131I-GMIB-Anti-HER2-VHH1 is a targeted radionuclide theranostic agent directed at HER2 expressing cancers. VHH1 is a single domain antibody fragment covalently linked to therapeutic radio-iodine 131I via the linker SGMIB. The Phase I stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5332bb7a8f8e41c596fc523593f63dc0
https://research.vumc.nl/en/publications/8c6852db-7dae-40ad-b98a-16a2ca7c2938

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Population pharmacokinetic approach applied to positron emission tomography: Computed tomography for tumor tissue identification in patients with glioma

Autor: Bart Neyns, Etienne Chatelut, Peggy Gandia, Johnny Duerinck, Didier Concordet, Johannes Heemskerk, Mark De Ridder, Hendrik Everaert, Johan De Mey, Anne Vanbinst, Cyril Jaudet

Publikováno v: Clinical Pharmacokinetics
Clinical Pharmacokinetics, Springer Verlag, 2017, 56 (8), pp.953-961. ⟨10.1007/s40262-016-0490-4⟩

BACKGROUND AND AIMS: 18F-fluoro-ethyl-tyrosine (FET) is a radiopharmaceutical used in positron emission tomography (PET)-computed tomography in patients with glioma. We propose an original approach combining a radiotracer-pharmacokinetic exploration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ab926883cc46a4545d136d6465ba7b
https://hal.archives-ouvertes.fr/hal-01601882

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Improved EMCCD gamma camera performance by SiPM pre-localization

Autor: J. Huizenga, R. Kreuger, Freek J Beekman, Dennis R. Schaart, S. Salvador, Johannes Heemskerk, Marc A N Korevaar, Stefan Seifert

Publikováno v: Physics in Medicine and Biology. 57:7709-7724

High spatial resolution γ-imaging can be achieved with scintillator readout by low-noise, fast, electron-multiplying charge-coupled devices (EMCCDs). Previously we have shown that false-positive events due to EMCCD noise can be rejected by using the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ce317927d17ffcaaf848224ce98025
https://doi.org/10.1088/0031-9155/57/22/7709

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Phase I Study of 68Ga-HER2-Nanobody for PET/CT Assessment of HER2 Expression in Breast Carcinoma

Autor: Ilse Vaneycken, Catarina Xavier, Chloé Ackaert, Nick Devoogdt, Christian Vanhove, Thierry Gevaert, Christel Fontaine, Tony Lahoutte, Hendrik Everaert, Denis Schallier, François Duhoux, Johannes Heemskerk, Marian Vanhoeij, Jan Lamote, Marleen Keyaerts, Vicky Caveliers, Philippe Simon, Jacques De Greve

Publikováno v: JOURNAL OF NUCLEAR MEDICINE

UNLABELLED: Human epidermal growth factor receptor 2 (HER2) status is one of the major tumor characteristics in breast cancer to guide therapy. Anti-HER2 treatment has clear survival advantages in HER2-positive breast carcinoma patients. Heterogeneit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e3d404e5422d656391c2ac077a9749
https://pubmed.ncbi.nlm.nih.gov/26449837

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PET Imaging of Macrophage Mannose Receptor-Expressing Macrophages in Tumor Stroma Using 18F-Radiolabeled Camelid Single-Domain Antibody Fragments

Autor: Johannes Heemskerk, Steve Schoonooghe, Guy Bormans, Damya Laoui, Patrick De Baetselier, Ilse Vaneycken, Frederik Cleeren, Kevin D’hoe, Matthias D'Huyvetter, Jo A. Van Ginderachter, Tony Lahoutte, Vicky Caveliers, Catarina Xavier, Anneleen Blykers, Nick Devoogdt, Geert Raes

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 56(8)

UNLABELLED: Tumor-associated macrophages constitute a major component of the stroma of solid tumors, encompassing distinct subpopulations with different characteristics and functions. We aimed to identify M2-oriented tumor-supporting macrophages with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba0e9241265f61e0a7002b286c30a82
https://pubmed.ncbi.nlm.nih.gov/26069306

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Radiolabeled mannosylated dextran derivatives bearing an NIR-fluorophore for sentinel lymph node imaging

Autor: Catarina Xavier, Vicky Caveliers, Johannes Heemskerk, Sophie Hernot, Isabel Santos, Maurício Morais, João D. G. Correia, Maria Paula Cabral Campello, Tony Lahoutte

Publikováno v: Bioconjugate chemistry. 25(11)

Current methods for sentinel lymph node (SLN) mapping involve the use of radioactivity detection with technetium-99m sulfur colloid and/or visually guided identification using a blue dye. To overcome the kinetic variations of two individual imaging a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d53d65a7557a5a60be88a5e5d1c979
https://pubmed.ncbi.nlm.nih.gov/25529056

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