Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Johannes, Delp"'
Autor:
Ilinca Suciu, Johannes Delp, Simon Gutbier, Julian Suess, Lars Henschke, Ivana Celardo, Thomas U. Mayer, Ivano Amelio, Marcel Leist
Publikováno v:
Antioxidants, Vol 13, Iss 1, p 49 (2023)
To characterize the hits from a phenotypic neurotoxicity screen, we obtained transcriptomics data for valinomycin, diethylstilbestrol, colchicine, rotenone, 1-methyl-4-phenylpyridinium (MPP), carbaryl and berberine (Ber). For all compounds, the conce
Externí odkaz:
https://doaj.org/article/d14bd21b61f34faebef6551f3883bb2f
Autor:
Ilinca Suciu, Johannes Delp, Simon Gutbier, Anna-Katharina Ückert, Anna-Sophie Spreng, Philipp Eberhard, Christiaan Karreman, Falk Schreiber, Katrin Madjar, Jörg Rahnenführer, Ivana Celardo, Ivano Amelio, Marcel Leist
Publikováno v:
Antioxidants, Vol 12, Iss 1, p 164 (2023)
Proteasome inhibition is associated with parkinsonian pathology in vivo and degeneration of dopaminergic neurons in vitro. We explored here the metabolome (386 metabolites) and transcriptome (3257 transcripts) regulations of human LUHMES neurons, fol
Externí odkaz:
https://doaj.org/article/aba2f698f7c54e15a5b78be17f1451a9
Autor:
Cleo Tebby, Wang Gao, Johannes Delp, Giada Carta, Wanda van der Stel, Marcel Leist, Paul Jennings, Bob van de Water, Frederic Y. Bois
Publikováno v:
Toxicology in Vitro, 81:105345, 1-16. Elsevier Limited
Toxicology in Vitro
Tebby, C, Gao, W, Delp, J, Carta, G, van der Stel, W, Leist, M, Jennings, P, van de Water, B & Bois, F Y 2022, ' A quantitative AOP of mitochondrial toxicity based on data from three cell lines ', Toxicology in Vitro, vol. 81, 105345, pp. 1-16 . https://doi.org/10.1016/j.tiv.2022.105345
Toxicology In Vitro, 81:105345
Toxicology in Vitro
Tebby, C, Gao, W, Delp, J, Carta, G, van der Stel, W, Leist, M, Jennings, P, van de Water, B & Bois, F Y 2022, ' A quantitative AOP of mitochondrial toxicity based on data from three cell lines ', Toxicology in Vitro, vol. 81, 105345, pp. 1-16 . https://doi.org/10.1016/j.tiv.2022.105345
Toxicology In Vitro, 81:105345
Adverse Outcome Pathways (AOPs) are increasingly used to support the integration of in vitro data in hazard assessment for chemicals. Quantitative AOPs (qAOPs) use mathematical models to describe the relationship between key events (KEs). In this pap
Autor:
Hanne R. Gerding, Christiaan Karreman, Andreas Daiber, Johannes Delp, Daniel Hammler, Martin Mex, Stefan Schildknecht, Marcel Leist
Publikováno v:
Redox Biology, Vol 26, Iss , Pp - (2019)
Tyrosine nitration is a post-translational protein modification relevant to various pathophysiological processes. Chemical nitration procedures have been used to generate and study nitrated proteins, but these methods regularly lead to modifications
Externí odkaz:
https://doaj.org/article/aec6c6ca0aba411db5a5b5b4b3a6eb25
Autor:
Wanda van der Stel, Susanne Hougaard Bennekou, Anna Forsby, Paul Jennings, Johannes Delp, Marcel Leist, Bob van de Water, Ilinca Suciu, Petra Kranaster, Giada Carta, Vesna Munic Kos, Andrea Cediel-Ulloa, Barbara M.A. van Vugt-Lussenburg
Publikováno v:
Archives of Toxicology
Delp, J, Cediel-Ulloa, A, Suciu, I, Kranaster, P, van Vugt-Lussenburg, B M, Munic Kos, V, van der Stel, W, Carta, G, Bennekou, S H, Jennings, P, van de Water, B, Forsby, A & Leist, M 2021, ' Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors ', Archives of Toxicology, vol. 95, no. 2, pp. 591-615 . https://doi.org/10.1007/s00204-020-02970-5
Archives of Toxicology, 95, 591-615. Springer Science and Business Media LLC
Archives of Toxicology, 95(2), 591-615. Springer Verlag
Delp, J, Cediel-Ulloa, A, Suciu, I, Kranaster, P, van Vugt-Lussenburg, B M, Munic Kos, V, van der Stel, W, Carta, G, Bennekou, S H, Jennings, P, van de Water, B, Forsby, A & Leist, M 2021, ' Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors ', Archives of Toxicology, vol. 95, pp. 591–615 . https://doi.org/10.1007/s00204-020-02970-5
Delp, J, Cediel-Ulloa, A, Suciu, I, Kranaster, P, van Vugt-Lussenburg, B M, Munic Kos, V, van der Stel, W, Carta, G, Bennekou, S H, Jennings, P, van de Water, B, Forsby, A & Leist, M 2021, ' Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors ', Archives of Toxicology, vol. 95, no. 2, pp. 591-615 . https://doi.org/10.1007/s00204-020-02970-5
Archives of Toxicology, 95, 591-615. Springer Science and Business Media LLC
Archives of Toxicology, 95(2), 591-615. Springer Verlag
Delp, J, Cediel-Ulloa, A, Suciu, I, Kranaster, P, van Vugt-Lussenburg, B M, Munic Kos, V, van der Stel, W, Carta, G, Bennekou, S H, Jennings, P, van de Water, B, Forsby, A & Leist, M 2021, ' Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors ', Archives of Toxicology, vol. 95, pp. 591–615 . https://doi.org/10.1007/s00204-020-02970-5
Inhibition of complex I of the mitochondrial respiratory chain (cI) by rotenone and methyl-phenylpyridinium (MPP +) leads to the degeneration of dopaminergic neurons in man and rodents. To formally describe this mechanism of toxicity, an adverse outc
Autor:
Paul Jennings, Giada Carta, Johannes P Schimming, Erik H.J. Danen, Marcel Leist, Giulia Callegaro, Nanette G Vrijenhoek, Joost B. Beltman, Anna Forsby, Johannes Delp, Andrew White, Bob van de Water, Sylvia E. Le Dévédec, Huan Yang, Wanda van der Stel, Salihanur Darici
Publikováno v:
van der Stel, W, Yang, H, Vrijenhoek, N G, Schimming, J P, Callegaro, G, Carta, G, Darici, S, Delp, J, Forsby, A, White, A, le Dévédec, S, Leist, M, Jennings, P, Beltman, J B, van de Water, B & Danen, E H J 2022, ' Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation ', Archives of Toxicology, vol. 96, no. 1, pp. 259-285 . https://doi.org/10.1007/s00204-021-03160-7
Archives of Toxicology, 96
Archives of Toxicology
Archives of Toxicology, 96(1), 259-285. Springer Verlag
Archives of Toxicology, 96
Archives of Toxicology
Archives of Toxicology, 96(1), 259-285. Springer Verlag
Mitochondrial perturbation is a key event in chemical-induced organ toxicities that is incompletely understood. Here, we studied how electron transport chain (ETC) complex I, II, or III (CI, CII and CIII) inhibitors affect mitochondrial functionality
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e5ec3b4fb4c6608dfe265e2934a630
https://hdl.handle.net/1871.1/e0b19077-5a27-48fb-bc1b-0dc3bbb415f8
https://hdl.handle.net/1871.1/e0b19077-5a27-48fb-bc1b-0dc3bbb415f8
Autor:
P Ripani, V M Betzler, Johannes Delp, Thomas Brunner, N Yan, Konstantin J. Bode, Thomas U. Mayer, M E Delgado, Marcel Leist, G von Scheven, Lea Dietrich
Publikováno v:
Oncogene
Systemic toxicity and tumor cell resistance still limit the efficacy of chemotherapy in colorectal cancer. Therefore, alternative treatments are desperately needed. The thiazolide Nitazoxanide (NTZ) is an FDA-approved drug for the treatment of parasi
Autor:
Karla Aparecida Guimarães Gusmão Gomes, Vivian Louise Soares de Oliveira, Patrícia Silva Cisalpino, Simone Odília Antunes Fernandes, Johannes Delp, Jarbas M. Resende, Luiz de Macêdo Farias, Daiane Boff, Maria Elena de Lima, Adriano Monteiro de Castro Pimenta, Flávio A. Amaral, Paula Prazeres Magalhães, Leonardo Lima Fuscaldi, Marcel Leist, Daniel Moreira dos Santos, Rosana de Carvalho Cruz, Elaine M. Souza-Fagundes, Valbert Nascimento Cardoso, Joaquim Teixeira de Avelar Júnior, Patrícia Luciana de Oliveira
Publikováno v:
Repositório Institucional da UFMG
Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior In the continuing search for novel ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b86ba66a75e11c027918b66fe7217e
Autor:
Leonardo Lima, Fuscaldi, Joaquim Teixeira, de Avelar Júnior, Daniel Moreira, Dos Santos, Daiane, Boff, Vívian Louise Soares, de Oliveira, Karla Aparecida Guimarães Gusmão, Gomes, Rosana de Carvalho, Cruz, Patrícia Luciana, de Oliveira, Paula Prazeres, Magalhães, Patricia Silva, Cisalpino, Luiz de Macêdo, Farias, Elaine Maria, de Souza-Fagundes, Johannes, Delp, Marcel, Leist, Jarbas Magalhães, Resende, Flávio Almeida, Amaral, Adriano Monteiro de Castro, Pimenta, Simone Odília Antunes, Fernandes, Valbert Nascimento, Cardoso, Maria Elena, de Lima
Publikováno v:
Exp Biol Med (Maywood)
In the continuing search for novel antibiotics, antimicrobial peptides are promising molecules, due to different mechanisms of action compared to classic antibiotics and to their selectivity for interaction with microorganism cells rather than with m
Autor:
Anna Forsby, Iain Gardner, Erik H.J. Danen, Paul Jennings, Julie Eakins, Susanne Hougaard Bennekou, Marcel Leist, Wanda van der Stel, Salihanur Darici, Giada Carta, Johannes Delp, Bob van de Water, Paul Walker
Publikováno v:
Arch Toxicol
van der Stel, W, Carta, G, Eakins, J, Darici, S, Delp, J, Forsby, A, Bennekou, S H, Gardner, I, Leist, M, Danen, E H J, Walker, P, van de Water, B & Jennings, P 2020, ' Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals ', Archives of Toxicology, vol. 94, pp. 2707–2729 . https://doi.org/10.1007/s00204-020-02792-5
Archives of Toxicology
van der Stel, W, Carta, G, Eakins, J, Darici, S, Delp, J, Forsby, A, Bennekou, S H, Gardner, I, Leist, M, Danen, E H J, Walker, P, van de Water, B & Jennings, P 2020, ' Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals ', Archives of Toxicology, vol. 94, no. 8, pp. 2707-2729 . https://doi.org/10.1007/s00204-020-02792-5
Archives of Toxicology, 94(8), 2707-2729
Archives of Toxicology, 94(8), 2707-2729. Springer Verlag
van der Stel, W, Carta, G, Eakins, J, Darici, S, Delp, J, Forsby, A, Bennekou, S H, Gardner, I, Leist, M, Danen, E H J, Walker, P, van de Water, B & Jennings, P 2020, ' Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals ', Archives of Toxicology, vol. 94, pp. 2707–2729 . https://doi.org/10.1007/s00204-020-02792-5
Archives of Toxicology
van der Stel, W, Carta, G, Eakins, J, Darici, S, Delp, J, Forsby, A, Bennekou, S H, Gardner, I, Leist, M, Danen, E H J, Walker, P, van de Water, B & Jennings, P 2020, ' Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals ', Archives of Toxicology, vol. 94, no. 8, pp. 2707-2729 . https://doi.org/10.1007/s00204-020-02792-5
Archives of Toxicology, 94(8), 2707-2729
Archives of Toxicology, 94(8), 2707-2729. Springer Verlag
Evidence is mounting for the central role of mitochondrial dysfunction in several pathologies including metabolic diseases, accelerated ageing, neurodegenerative diseases and in certain xenobiotic-induced organ toxicity. Assessing mitochondrial pertu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c62e4a962eeafee36938d0bc3f7c14
https://doi.org/10.1007/s00204-020-02792-5
https://doi.org/10.1007/s00204-020-02792-5