Study protocol of a phase 2, randomised, placebo-controlled, double-blind, adaptive, parallel group clinical study to evaluate the efficacy and safety of recombinant alpha-1-microglobulin in subjects at high risk for acute kidney injury following open-chest cardiac surgery (AKITA trial)

Autor: Alexander Zarbock, Jay L Koyner, Andre Lamy, C David Mazer, Nicolas Noiseux, Benoit de Varennes, Johannes Boehm, Matthias Thielmann, Claudio Ronco, Thilo von Groote, Niloufar Siadati-Fini, Felix Wirth, Andrej Myjavec, Craig D Brown, Andreas Boening, Daniel T Engelman, Tobias E Larsson, Ronny Renfurm, Maxime Laflamme

Publikováno v: BMJ Open, Vol 13, Iss 4 (2023)

Introduction Acute kidney injury (AKI) is a common complication after cardiac surgery (CS) and is associated with adverse short-term and long-term outcomes. Alpha-1-microglobulin (A1M) is a circulating glycoprotein with antioxidant, heme binding and

Externí odkaz: https://doaj.org/article/0d3d023ac8cf44fcbf4b88db2d4a2c83

Vertical Integration and Foreclosure: Evidence from Production Network Data

Autor: Johannes Boehm, Jan Sonntag

Publikováno v: Management Science. 69:141-161

This paper studies the prevalence of potential anticompetitive effects of vertical mergers using a novel data set on U.S. and international buyer-seller relationships and across a large range of industries. We find that relationships are more likely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0c1ec20969ac13c84be596108257d6
https://doi.org/10.1287/mnsc.2022.4363

The Impact of Contract Enforcement Costs on Value Chains and Aggregate Productivity

Autor: Johannes Boehm

Publikováno v: The Review of Economics and Statistics. 104:34-50

I study how supplier contracting frictions shape the patterns of intermediate input use and quantify the impact of these distortions on aggregate productivity. Using the frequency of litigation between US firms as a novel measure to capture the need

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3cc08b0cad100361cb12fb22f007a569
https://doi.org/10.1162/rest_a_00940

Excellent Hemodynamic Performance After Aortic Valve Neocuspidization Using Autologous Pericardium

Autor: Johannes Boehm, Rüdiger Lange, Johannes Holfeld, Anatol Prinzing, Markus Krane, Johannes Amadeus Ziegelmueller

Publikováno v: The Annals of Thoracic Surgery. 111:126-133

Aortic valve neocuspidization (AVNeo) for trileaflet aortic valve reconstruction using autologous pericardium (Ozaki procedure) offers an alternative treatment modality to overcome drawbacks of conventional prosthetic aortic valve replacement.Between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d627f60467b8e2370a1511fad4b5f75b
https://doi.org/10.1016/j.athoracsur.2020.04.108

Surgical Aortic Valve Replacement—Age-Dependent Choice of Prosthesis Type

Autor: Markus Krane, Melchior Burri, Keti Vitanova, Rüdiger Lange, Felix Wirth, Johannes Boehm

Publikováno v: Journal of Clinical Medicine; Volume 10; Issue 23; Pages: 5554
Journal of Clinical Medicine
Journal of Clinical Medicine, Vol 10, Iss 5554, p 5554 (2021)

Background: Recently, the use of surgically implanted aortic bioprostheses has been favoured in younger patients. We aimed to analyse the long-term survival and postoperative MACCE (Major Adverse Cardiovascular and Cerebral Event) rates in patients a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d206dbc2baeab79fd8d476899a1e9af4