Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Johanneke E. Van der Harst"'
Autor:
Giuseppe Manfré, Erik K. H. Clemensson, Elisavet I. Kyriakou, Laura E. Clemensson, Johanneke E. van der Harst, Judith R. Homberg, Huu Phuc Nguyen
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 11 (2017)
Rationale: Huntington disease (HD) is a progressive neurodegenerative disorder characterized by motor, cognitive and neuropsychiatric symptoms. HD is usually diagnosed by the appearance of motor deficits, resulting in skilled hand use disruption, gai
Externí odkaz:
https://doaj.org/article/90bc0acc49f648deb6cc9a4e9edbf356
Autor:
Giuseppe Manfré, Arianna Novati, Ilaria Faccini, Andrea C Rossetti, Kari Bosch, Raffaella Molteni, Marco A Riva, Johanneke E Van der Harst, Huu Phuc Nguyen, Judith R Homberg
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192289 (2018)
BACKGROUND:Huntington disease (HD) is a devastating inherited neurodegenerative disorder characterized by progressive motor, cognitive, and psychiatric symptoms without any cure to slow down or stop the progress of the disease. The BACHD rat model fo
Externí odkaz:
https://doaj.org/article/7d1dde89d98946568d562c0ea895bf4e
Autor:
Johanneke E. Van der Harst, Robert Wronski, Judith R. Homberg, Huu Phuc Nguyen, Giuseppe Manfré, Arianna Novati, Stefanie Flunkert
Publikováno v:
Behavioural Brain Research, 393
Behavioural Brain Research
Behavioural Brain Research
Huntington disease (HD) is a neurodegenerative disorder caused by a polyglutamine expansion in the HTT gene. Various HD animal models have been generated to mimic the motor, cognitive and neuropsychiatric disturbances that affect HD patients. Reprodu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c371df903abd16fd74f30e40af6397
http://hdl.handle.net/2066/221717
http://hdl.handle.net/2066/221717
Publikováno v:
Journal of Neuroscience Methods, 300, 48-58
Journal of Neuroscience Methods, 300, pp. 48-58
Journal of Neuroscience Methods, 300, pp. 48-58
Background Measuring anxiety in a reliable manner is essential for behavioural phenotyping of rodent models such as the rat model for Spinocerebellar ataxia type 17 (SCA17) where anxiety is reported in patients. An automated tool for assessing anxiet
Autor:
Ilona J. Pinter, Berry M. Spruijt, Joe A. Tuffnell, Suzanne M. Peters, Johanneke E. van der Harst
Publikováno v:
Behavioural Brain Research. 325:34-43
Phencyclidine (PCP) has been suggested to induce symptoms of schizophrenia . However, animal models using PCP administration have produced ambiguous results thus far. It seems that acute effects are similar to symptoms of schizophrenia, however, it i
Autor:
Raymond C. de Heer, Judith R. Homberg, Andrew Spink, Elisavet I. Kyriakou, Huu Phuc Nguyen, Johanneke E. Van der Harst, Jan G. van der Kieft
Publikováno v:
Journal of Neuroscience Methods. 268:171-181
Background An objective and automated method for assessing alterations in gait and motor coordination in different animal models is important for proper gait analysis. The CatWalk system has been used in pain research, ischemia, arthritis, spinal cor
Autor:
Arianna Novati, Huu Phuc Nguyen, Judith R. Homberg, Giuseppe Manfré, Ilaria Faccini, Johanneke E. Van der Harst
Publikováno v:
Models for HD.
Background Social behavior related symptoms and sexual disturbances are frequently reported in Huntington disease (HD) patients, but scarcely studied in animal models. The BACHD rat model for HD carries the human full length mutated HTT with 97 CAG-C
Autor:
Huu Phuc Nguyen, Judith R. Homberg, Giuseppe Manfré, Jesús A. Spadaro, Elisavet I. Kyriakou, Johanneke E. Van der Harst
Publikováno v:
Behavioural Brain Research, 321, 106-112
Behavioural Brain Research, 321, pp. 106-112
Behavioural Brain Research, 321, pp. 106-112
Contains fulltext : 169896.pdf (Publisher’s version ) (Closed access) Anxiety as a common feature of several neurodegenerative/polyglutamine diseases is an important aspect for the face validity of an animal model for Spinocerebellar Ataxia type 17
Autor:
Kari Bosch, Raffaella Molteni, Johanneke E. Van der Harst, Judith R. Homberg, Andrea C. Rossetti, Giuseppe Manfré, Ilaria Faccini, Marco A. Riva, Huu Phuc Nguyen, Arianna Novati
Publikováno v:
PLoS One, 13
PLoS ONE, Vol 13, Iss 2, p e0192289 (2018)
PLoS ONE
PLoS One, 13, 2
PLoS ONE, Vol 13, Iss 2, p e0192289 (2018)
PLoS ONE
PLoS One, 13, 2
Background Huntington disease (HD) is a devastating inherited neurodegenerative disorder characterized by progressive motor, cognitive, and psychiatric symptoms without any cure to slow down or stop the progress of the disease. The BACHD rat model fo
Autor:
Johanneke E. van der Harst, Geert M.J. Ramakers, Berry M. Spruijt, Annemarie M. Baars, Chantal M. Kapteijn, Amer Kamal
Publikováno v:
Experimental Brain Research. Experimentelle Hirnforschung. Experimentation Cerebrale
Chronic stress causes insensitivity to rewards (anhedonia) in rats, reflected by the absence of anticipatory behavior for a sucrose-reward, which can be reversed by antidepressant treatment or repeated announced transfer to an enriched cage. It was,