Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Johanne M. Kaplan"'
Autor:
Beibei Zhao, Catherine M. Cowan, Juliane A. Coutts, Darren D. Christy, Ananya Saraph, Shawn C. C. Hsueh, Stephen S. Plotkin, Ian R. Mackenzie, Johanne M. Kaplan, Neil R. Cashman
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract TAR DNA-binding protein 43 (TDP-43) and Fused in Sarcoma/Translocated in Sarcoma (FUS) are ribonucleoproteins associated with pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Under physiologic
Externí odkaz:
https://doaj.org/article/1d6e11bc4ae24e4888e214787663cda9
Autor:
Ebrima Gibbs, Beibei Zhao, Andrei Roman, Steven S. Plotkin, Xubiao Peng, Shawn C. C. Hsueh, Adekunle Aina, Jing Wang, Clay Shyu, Calvin K. Yip, Sung-Eun Nam, Johanne M. Kaplan, Neil R. Cashman
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2168 (2022)
Misfolded toxic forms of alpha-synuclein (α-Syn) have been implicated in the pathogenesis of synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). The α-Syn oligomers and solubl
Externí odkaz:
https://doaj.org/article/70f43dd6da744d4dbd18d14a33439f99
A Rationally Designed Humanized Antibody Selective for Amyloid Beta Oligomers in Alzheimer’s Disease
Autor:
Ebrima Gibbs, Judith M. Silverman, Beibei Zhao, Xubiao Peng, Jing Wang, Cheryl L. Wellington, Ian R. Mackenzie, Steven S. Plotkin, Johanne M. Kaplan, Neil R. Cashman
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Abstract Advances in the understanding of Alzheimer’s disease (AD) suggest that pathogenesis is not directly related to plaque burden, but rather to soluble toxic amyloid-beta oligomers (AßO). Therapeutic antibodies targeting Aß monomers and/or p
Externí odkaz:
https://doaj.org/article/7e17d617f44d4cba8b63f9167f89ea62
Autor:
Sambasiva P Rao, Jose Sancho, Juanita Campos-Rivera, Paula M Boutin, Peter B Severy, Timothy Weeden, Srinivas Shankara, Bruce L Roberts, Johanne M Kaplan
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39416 (2012)
Alemtuzumab is a monoclonal antibody that targets cell surface CD52 and is effective in depleting lymphocytes by cytolytic effects in vivo. Although the cytolytic effects of alemtuzumab are dependent on the density of CD52 antigen on cells, there is
Externí odkaz:
https://doaj.org/article/5deecdc8b16d435480f9c85d5a9e76d0
Publikováno v:
Circulation. 99:1776-1779
Background —Adenoviral constructs have been used for studies of injury-induced vascular hyperplasia in immunologically naive laboratory animals, but their usefulness for intra-arterial gene therapy may be limited by the prevalence of preexisting im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd911dbddf18fc14c31bb925b87a019
https://doi.org/10.1161/01.cir.99.14.1776
https://doi.org/10.1161/01.cir.99.14.1776
Autor:
Joan O'leary bartus, Peter J. Bugelski, Klaus Max Esser, Johanne M. Kaplan, Elizabeth V. Ruggieri, Danuta J. Herzyk
Publikováno v:
Toxicology. 95:187-196
BRL 61063 is a novel xanthine phosphodiesterase (PDE) type IV inhibitor with selective inhibitory activity for tumor necrosis factor (TNF) alpha production. This compound inhibits TNF alpha production by activated human blood monocytes in vitro and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28fc7b2243e0aea4c93902c8bb6f1638
https://doi.org/10.1016/0300-483x(94)02922-h
https://doi.org/10.1016/0300-483x(94)02922-h
Autor:
Elizabeth V. Ruggieri, Peter J. Bugelski, Johanne M. Kaplan, Alison M. Badger, Barbara A. Swift
Publikováno v:
International Journal of Immunopharmacology. 15:113-123
SK&F 105685 (N,N-dimethyl-8,8-dipropyl-2-azaspiro[4,5]decane-2-propanamine dihydrochloride) is a novel azaspirane with beneficial activity in animal models of autoimmune disease such as adjuvant-induced arthritis and experimental encephalomyelitis in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3062d031d727eea02e5fe08936d8d9
https://doi.org/10.1016/0192-0561(93)90087-f
https://doi.org/10.1016/0192-0561(93)90087-f
Autor:
Peter J. Bugelski, Timothy K. Hart, Richard Kirsh, John C. Lee, Johanne M. Kaplan, Geoffrey B. Dreyer, Joanne Miller, Jeffery T. Laydon
Publikováno v:
AIDS Research and Human Retroviruses. 8:1951-1958
Human immunodeficiency virus (HIV) is the cause of acquired immunodeficiency syndrome (AIDS). Encoded by the HIV genome are several precursor proteins that undergo proteolytic cleavage to yield functional proteins. The env precursor protein is cleave
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015a667af0db2ba99bc8826da419b7ce
https://doi.org/10.1089/aid.1992.8.1951
https://doi.org/10.1089/aid.1992.8.1951
Autor:
Peter J. Bugelski, Elizabeth V. Ruggieri, Johanne M. Kaplan, Patricia A. Thiem, Alison M. Badger
Publikováno v:
Immunopharmacology. 23:67-74
SKF 105.685 (N,N-dimethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamine+ ++ dihydrochloride) is a novel azaspirane with beneficial activity in rat models of adjuvant-induced arthritis and experimental autoimmune encephalomyelitis as well as in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ad8b4c97cc0ed9910f0965d1912aac4
https://doi.org/10.1016/0162-3109(92)90029-c
https://doi.org/10.1016/0162-3109(92)90029-c
Autor:
Peter J. Bugelski, Steven C. Boike, Diane K. Jorkasky, Francis D. Moore, John Lipani, Daniel Everitt, Frederick DeClement, Elizabeth V. Ruggieri, Johanne M. Kaplan, Danuta J. Herzyk
Publikováno v:
Journal of clinical immunology. 16(2)
The relationships between antibodies against human soluble complement receptor 1 (hsCR1) were studied in rodents, dogs, nonhuman primates, and humans. An antibody response occurred in all species except humans. The anti-hsCR1 antibodies from the vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fea97019e73df7447d5da452b50fdbeb
https://pubmed.ncbi.nlm.nih.gov/8690778
https://pubmed.ncbi.nlm.nih.gov/8690778