Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Johanne H. Egedal"'
Autor:
Thomas A. Packard, Roland Schwarzer, Eytan Herzig, Deepashri Rao, Xiaoyu Luo, Johanne H. Egedal, Feng Hsiao, Marek Widera, Judd F. Hultquist, Zachary W. Grimmett, Ronald J. Messer, Nevan J. Krogan, Steven G. Deeks, Nadia R. Roan, Ulf Dittmer, Kim J. Hasenkrug, Warner C. Greene
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT HIV infects long-lived CD4 memory T cells, establishing a latent viral reservoir that necessitates lifelong antiretroviral therapy (ART). How this reservoir is formed so quickly after infection remains unclear. We now show the innate inflamm
Externí odkaz:
https://doaj.org/article/0c31ebd503514659ba779d1be8395425
Autor:
Jesper G. Pedersen, Johanne H. Egedal, Thomas A. Packard, Karthiga Thavachelvam, Guorui Xie, Renée Marije van der Sluis, Warner C. Greene, Nadia R. Roan, Martin R. Jakobsen
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
The chemokine receptor CCR5 is expressed on multiple cell types, including macrophages, dendritic cells, and T cells, and is the major co-receptor used during HIV transmission. Using a standard αCD3/CD28 in vitro stimulation protocol to render CD4+
Externí odkaz:
https://doaj.org/article/645cdc5c0c3440dcb09dfb4688ca1a1b
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Dendritic cells (DCs) play a critical role in mediating innate and adaptive immune responses. Since their discovery in the late 1970's, DCs have been recognized as the most potent antigen-presenting cells (APCs). DCs have a superior capacity for acqu
Externí odkaz:
https://doaj.org/article/9ffa81afbf7e4e31a996d0c9fe86d8b5
Autor:
Søren Lomholt, Elena Neumann, Ulf Müller-Ladner, Bent Deleuran, Ditte Køster, Tue Wenzel Kragstrup, Hermann Eibel, Morten Aagaard Nielsen, Johanne H Egedal, Martin R. Jakobsen, Malene Hvid
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Køster, D, Egedal, J H, Lomholt, S, Hvid, M, Jakobsen, M R, Müller-Ladner, U, Eibel, H, Deleuran, B, Kragstrup, T W, Neumann, E & Nielsen, M A 2021, ' Phenotypic and functional characterization of synovial fluid-derived fibroblast-like synoviocytes in rheumatoid arthritis ', Scientific Reports, vol. 11, no. 1, 22168 . https://doi.org/10.1038/s41598-021-01692-7
Scientific Reports
Køster, D, Egedal, J H, Lomholt, S, Hvid, M, Jakobsen, M R, Müller-Ladner, U, Eibel, H, Deleuran, B, Kragstrup, T W, Neumann, E & Nielsen, M A 2021, ' Phenotypic and functional characterization of synovial fluid-derived fibroblast-like synoviocytes in rheumatoid arthritis ', Scientific Reports, vol. 11, no. 1, 22168 . https://doi.org/10.1038/s41598-021-01692-7
Scientific Reports
Fibroblast-like synoviocytes (FLS) play an important pathological role in persistent inflammatory joint diseases such as rheumatoid arthritis (RA). These cells have primarily been characterized in the RA synovial membrane. Here we aim to phenotypical
Autor:
Martin R Jakobsen, Warner C. Greene, Guorui Xie, Anders Laustsen, Jason Neidleman, Satish K. Pillai, Johanne H Egedal, Thomas A. Packard, Nadia R. Roan, Konstantinos Georgiou
Publikováno v:
Mucosal immunology, vol 14, iss 5
Egedal, J H, Xie, G, Packard, T A, Laustsen, A, Neidleman, J, Georgiou, K, Pillai, S K, Greene, W C, Jakobsen, M R & Roan, N R 2021, ' Hyaluronic acid is a negative regulator of mucosal fibroblast-mediated enhancement of HIV infection ', Mucosal Immunology, vol. 14, no. 5, pp. 1203-1213 . https://doi.org/10.1038/s41385-021-00409-3
Mucosal Immunology
Egedal, J H, Xie, G, Packard, T A, Laustsen, A, Neidleman, J, Georgiou, K, Pillai, S K, Greene, W C, Jakobsen, M R & Roan, N R 2021, ' Hyaluronic acid is a negative regulator of mucosal fibroblast-mediated enhancement of HIV infection ', Mucosal Immunology, vol. 14, no. 5, pp. 1203-1213 . https://doi.org/10.1038/s41385-021-00409-3
Mucosal Immunology
The majority of HIV infections are established through the genital or rectal mucosa. Fibroblasts are abundant in these tissues, and although not susceptible to infection, can potently enhance HIV infection of CD4+ T cells. Hyaluronic acid (HA) is a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73953fb13cd9e0152e4d4bbab72b84df
https://escholarship.org/uc/item/1c4954vc
https://escholarship.org/uc/item/1c4954vc
Autor:
Tue Wenzel Kragstrup, Ulf Müller-Ladner, Elena Neumann, Morten Nielsen, Johanne H Egedal, Ditte Køster, Martin R. Jakobsen, Malene Hvid, Bent Deleuran
Publikováno v:
Annals of the Rheumatic Diseases. 79:1349.1-1349
Background:Fibroblast-like synoviocytes (FLS) are central cellular components in persistent inflammatory joint diseases such as rheumatoid arthritis (RA). Pathological subsets of FLS have been identified from synovial tissue. However, the synovial ti
IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
Autor:
Jacob Giehm Mikkelsen, Mogens Johannsen, Mette Nyegaard, Anders Laustsen, Chenglong Sun, Mads Kjolby, Pejman Mohammadi, Martin R. Jakobsen, Dominik Hotter, Thaneas Prabakaran, Søren R. Paludan, Lambert K. Sørensen, Kristian Alsbjerg Skipper, Johanne H Egedal, Karthiga Thavachelvam, Kasper L Jønsson, Frank Kirchhoff, Søren B. Jensen, Christian K. Holm, Christian Krapp, Robert Jan Lebbink
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Jønsson, K L, Laustsen, A, Krapp, C, Skipper, K A, Thavachelvam, K, Hotter, D, Egedal, J H, Kjolby, M, Mohammadi, P, Prabakaran, T, Sørensen, L K, Sun, C, Jensen, S B, Holm, C K, Lebbink, R J, Johannsen, M, Nyegaard, M, Mikkelsen, J G, Kirchhoff, F, Paludan, S R & Jakobsen, M R 2017, ' IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP ', Nature Communications, vol. 8, 14391 . https://doi.org/10.1038/ncomms14391
Nature Communications
Nature Communications [E], 8. Nature Publishing Group
Jønsson, K L, Laustsen, A, Krapp, C, Skipper, K A, Thavachelvam, K, Hotter, D, Egedal, J H, Kjolby, M, Mohammadi, P, Prabakaran, T, Sørensen, L K, Sun, C, Jensen, S B, Holm, C K, Lebbink, R J, Johannsen, M, Nyegaard, M, Mikkelsen, J G, Kirchhoff, F, Paludan, S R & Jakobsen, M R 2017, ' IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP ', Nature Communications, vol. 8, 14391 . https://doi.org/10.1038/ncomms14391
Nature Communications
Nature Communications [E], 8. Nature Publishing Group
Innate immune activation by macrophages is an essential part of host defence against infection. Cytosolic recognition of microbial DNA in macrophages leads to induction of interferons and cytokines through activation of cyclic GMP-AMP synthase (cGAS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ce14ccd79c5928ca15f6b72d02c316
https://dspace.library.uu.nl/handle/1874/350466
https://dspace.library.uu.nl/handle/1874/350466
Autor:
Thomas Alexander Packard, Eytan Herzig, Xiaoyu Luo, Johanne H Egedal, Zachary W Grimmett, Kim J Hasenkrug, Nadia Roan, Warner C Greene
Publikováno v:
The Journal of Immunology. 202:197.2-197.2
Seeding of the latent HIV reservoir occurs quickly within hours to a few days after initial viral infection. It is the persistence of virus within this reservoir that thwarts an HIV cure and necessitates life-long antiretroviral therapy (ART). Centra