CDX2 expression and perioperative patient serum affects the adhesion properties of cultured colon cancer cells

Autor: Johanne Davidsen, Stine Bull Jessen, Sara Kehlet Watt, Sylvester Larsen, Katja Dahlgaard, Tove Kirkegaard, Ismail Gögenur, Jesper T. Troelsen

Publikováno v: BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020)

Abstract Background Colon cancer is one of the most commonly diagnosed types of cancer with surgical resection of the tumor being the primary choice of treatment. However, the surgical stress response induced during treatment may be related to a high

Externí odkaz: https://doaj.org/article/eba229a27dc84e4fbfbc33651debd881

CDX2 regulates interleukin‐33 gene expression in intestinal epithelial cells (LS174T)

Autor: Claus Henrik Nielsen, Jakob Benedict Seidelin, Mehmet Coşkun, Sylvester Larsen, Ole Birger Pedersen, Eric P. Bennett, Jesper T. Troelsen, Johanne Davidsen, Katja Dahlgaard

Publikováno v: FEBS Open Bio, Vol 11, Iss 6, Pp 1638-1644 (2021)
FEBS Open Bio
Larsen, S, Seidelin, J B, Davidsen, J, Dahlgaard, K, Nielsen, C H, Bennett, E P, Pedersen, O B, Coskun, M & Troelsen, J T 2021, ' CDX2 regulates interleukin-33 gene expression in intestinal epithelial cells (LS174T) ', FEBS Open Bio, vol. 11, no. 6, pp. 1638-1644 . https://doi.org/10.1002/2211-5463.13161

Dysregulation of interleukin‐33 (IL‐33) has been implicated in the pathogenesis of several autoimmune and inflammatory diseases, but few studies have examined transcriptional regulation of the IL33 gene. In the intestines, gene regulation is cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0fab30203152c777098587cfeab7452
https://doi.org/10.1002/2211-5463.13161

HNF4α and CDX2 Regulate Intestinal YAP1 Promoter Activity

Autor: Johanne Davidsen, Sylvester Larsen, Ole Birger Pedersen, Jesper Thorvald Troelsen, Katja Dahlgaard

Publikováno v: International Journal of Molecular Sciences
Volume 20
Issue 12
Larsen, S, Davidsen, J, Dahlgaard, K, Pedersen, O B & Troelsen, J T 2019, ' HNF4α and CDX2 Regulate Intestinal YAP1 Promoter Activity ', International Journal of Molecular Sciences, vol. 20, no. 12, 2981 . https://doi.org/10.3390/ijms20122981
International Journal of Molecular Sciences, Vol 20, Iss 12, p 2981 (2019)

The Hippo pathway is important for tissue homeostasis, regulation of organ size andgrowth in most tissues. The co‐transcription factor yes‐associated protein 1 (YAP1) serves as a maindownstream effector of the Hippo pathway and its dysregulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6571b87e911255c5919ab0bb220a85db

The VTI1A-TCF4 colon cancer fusion protein is a dominant negative regulator of Wnt signaling and is transcriptionally regulated by intestinal homeodomain factor CDX2

Autor: Mehmet Coskun, Eric P. Bennett, Katja Dahlgaard, Ismail Gögenur, Jesper T. Troelsen, Sylvester Larsen, Johanne Davidsen

Publikováno v: PLoS ONE
Davidsen, J, Larsen, S, Coskun, M, Gögenur, I, Dahlgaard, K, Bennett, E P & Troelsen, J T 2018, ' The VTI1A-TCF4 colon cancer fusion protein is a dominant negative regulator of Wnt signaling and is transcriptionally regulated by intestinal homeodomain factor CDX2 ', PLoS ONE, vol. 13, no. 7, e0200215 . https://doi.org/10.1371/journal.pone.0200215
PLoS ONE, Vol 13, Iss 7, p e0200215 (2018)

Sequencing of primary colorectal tumors has identified a gene fusion in approximately 3% of colorectal cancer patients of the VTI1A and TCF7L2 genes, encoding a VTI1A-TCF4 fusion protein containing a truncated TCF4. As dysregulation of the Wnt signal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b091b3f7f92a11aa39f9543a12f8659
https://pubmed.ncbi.nlm.nih.gov/29975781