Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Johanne Ahrenfeldt"'
Autor:
Huiqiang Cai, Bin Zhang, Johanne Ahrenfeldt, Justin V. Joseph, Maria Riedel, Zongliang Gao, Sofie K. Thomsen, Ditte S. Christensen, Rasmus O. Bak, Henrik Hager, Mikkel H. Vendelbo, Xin Gao, Nicolai Birkbak, Martin K. Thomsen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Metastatic prostate cancer (PCa) poses a significant therapeutic challenge with high mortality rates. Utilizing CRISPR-Cas9 in vivo, we target five potential tumor suppressor genes (Pten, Trp53, Rb1, Stk11, and RnaseL) in the mouse prostate,
Externí odkaz:
https://doaj.org/article/b26426d9b48c4a0dba41510dd87eb43f
Autor:
Laura Iisager, Johanne Ahrenfeldt, Frede Donskov, Börje Ljungberg, Axel Bex, Lars Lund, Iben Lyskjær, Niels Fristrup
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-8 (2024)
Abstract Background Primary tumor removal by cytoreductive nephrectomy in synchronous metastatic renal cell carcinoma patients has been investigated in the context of various treatment regimens. Two randomized controlled trials investigated the role
Externí odkaz:
https://doaj.org/article/76866e452a284449961d4a715fa97939
Autor:
Laura Iisager, Johanne Ahrenfeldt, Anna Krarup Keller, Tommy Kjærgaard Nielsen, Niels Fristrup, Iben Lyskjær
Publikováno v:
Acta Oncologica, Vol 63, Iss 1 (2024)
Background: Management of localized renal cell carcinoma (RCC) is challenged by inaccurate methods to assess the risk of recurrence and deferred detection of relapse and residual disease after radical or partial nephrectomy. Circulating tumor DNA (ct
Externí odkaz:
https://doaj.org/article/09ed88d58e504938a238f78cd2525daa
Autor:
Johanne Ahrenfeldt, Ditte S Christensen, Andreas B Østergaard, Judit Kisistók, Mateo Sokač, Nicolai J Birkbak
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0281375 (2023)
Immunotherapy has revolutionised cancer treatment. However, not all cancer patients benefit, and current stratification strategies based primarily on PD1 status and mutation burden are far from perfect. We hypothesised that high activation of an inna
Externí odkaz:
https://doaj.org/article/2e10a8146a224eb3bc42295f9af6be36
Autor:
Johanne Ahrenfeldt, Ditte S. Christensen, Mateo Sokač, Judit Kisistók, Nicholas McGranahan, Nicolai J. Birkbak
Publikováno v:
Cancers, Vol 14, Iss 23, p 5817 (2022)
Cancer metastasis is the lethal developmental step in cancer, responsible for the majority of cancer deaths. To metastasise, cancer cells must acquire the ability to disseminate systemically and to escape an activated immune response. Here, we endeav
Externí odkaz:
https://doaj.org/article/f9b0934df7c947deb0b77f8f69e39548
Autor:
Martin Christen Frølund Thomsen, Johanne Ahrenfeldt, Jose Luis Bellod Cisneros, Vanessa Jurtz, Mette Voldby Larsen, Henrik Hasman, Frank Møller Aarestrup, Ole Lund
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157718 (2016)
Recent advances in whole genome sequencing have made the technology available for routine use in microbiological laboratories. However, a major obstacle for using this technology is the availability of simple and automatic bioinformatics tools. Based
Externí odkaz:
https://doaj.org/article/4ea6f859516549418b3593b159df43d8
Autor:
Nicolai J. Birkbak, Martin R. Jakobsen, Lars Dyrskjøt, Michael Knudsen, Thomas B.K. Watkins, Kevin Litchfield, Johanne Ahrenfeldt, Mateo Sokač
Supplementary data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c35d0c74d03c1247d17e90d41e82e3
https://doi.org/10.1158/2767-9764.22545327.v1
https://doi.org/10.1158/2767-9764.22545327.v1
Autor:
Nicolai J. Birkbak, Martin R. Jakobsen, Lars Dyrskjøt, Michael Knudsen, Thomas B.K. Watkins, Kevin Litchfield, Johanne Ahrenfeldt, Mateo Sokač
The cGAS-STING pathway serves a critical role in anticancer therapy. Particularly, response to immunotherapy is likely driven by both active cGAS-STING signaling that attracts immune cells, and by the presence of cancer neoantigens that presents as t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad056887e0d39a19b232c1443747b5a
https://doi.org/10.1158/2767-9764.c.6550911.v1
https://doi.org/10.1158/2767-9764.c.6550911.v1
Autor:
Nicolai J. Birkbak, Nicholas McGranahan, Lasse Maretty, Martin K. Thomsen, Judit Kisistók, Mateo Sokač, Johanne Ahrenfeldt, Ditte S. Christensen
Supplementary Data from Treatment Represents a Key Driver of Metastatic Cancer Evolution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f96ddda436f0a2cc809e1c21c59609a
https://doi.org/10.1158/0008-5472.22431749
https://doi.org/10.1158/0008-5472.22431749
Autor:
Nicolai J. Birkbak, Nicholas McGranahan, Lasse Maretty, Martin K. Thomsen, Judit Kisistók, Mateo Sokač, Johanne Ahrenfeldt, Ditte S. Christensen
Metastasis is the main cause of cancer death, yet the evolutionary processes behind it remain largely unknown. Here, through analysis of large panel-based genomic datasets from the AACR Genomics Evidence Neoplasia Information Exchange project, includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1feecd178204e8cbc10c9dd1799da198
https://doi.org/10.1158/0008-5472.c.6513971
https://doi.org/10.1158/0008-5472.c.6513971