Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Johannah L Butler"'
Autor:
Elizabeth K Speliotes, Laura M Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J Kim, Cameron D Palmer, Vilmundur Gudnason, Gudny Eiriksdottir, Melissa E Garcia, Lenore J Launer, Michael A Nalls, Jeanne M Clark, Braxton D Mitchell, Alan R Shuldiner, Johannah L Butler, Marta Tomas, Udo Hoffmann, Shih-Jen Hwang, Joseph M Massaro, Christopher J O'Donnell, Dushyant V Sahani, Veikko Salomaa, Eric E Schadt, Stephen M Schwartz, David S Siscovick, NASH CRN, GIANT Consortium, MAGIC Investigators, Benjamin F Voight, J Jeffrey Carr, Mary F Feitosa, Tamara B Harris, Caroline S Fox, Albert V Smith, W H Linda Kao, Joel N Hirschhorn, Ingrid B Borecki, GOLD Consortium
Publikováno v:
PLoS Genetics, Vol 7, Iss 3, p e1001324 (2011)
Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic variants influencing NAFLD using genome-wide association (GWA) analys
Externí odkaz:
https://doaj.org/article/c5813c26c983461e8c878bf0d8d9f7b5
Autor:
Charleston W K Chiang, Zofia K Z Gajdos, Joshua M Korn, Finny G Kuruvilla, Johannah L Butler, Rachel Hackett, Candace Guiducci, Thutrang T Nguyen, Rainford Wilks, Terrence Forrester, Christopher A Haiman, Katherine D Henderson, Loic Le Marchand, Brian E Henderson, Mark R Palmert, Colin A McKenzie, Helen N Lyon, Richard S Cooper, Xiaofeng Zhu, Joel N Hirschhorn
Publikováno v:
PLoS Genetics, Vol 6, Iss 3, p e1000866 (2010)
As we move forward from the current generation of genome-wide association (GWA) studies, additional cohorts of different ancestries will be studied to increase power, fine map association signals, and generalize association results to additional popu
Externí odkaz:
https://doaj.org/article/dd8333722d85479091e08623ee749a13
Autor:
Helen N Lyon, Valur Emilsson, Anke Hinney, Iris M Heid, Jessica Lasky-Su, Xiaofeng Zhu, Gudmar Thorleifsson, Steinunn Gunnarsdottir, G Bragi Walters, Unnur Thorsteinsdottir, Augustine Kong, Jeffrey Gulcher, Thuy Trang Nguyen, André Scherag, Arne Pfeufer, Thomas Meitinger, Günter Brönner, Winfried Rief, Manuel E Soto-Quiros, Lydiana Avila, Barbara Klanderman, Benjamin A Raby, Edwin K Silverman, Scott T Weiss, Nan Laird, Xiao Ding, Leif Groop, Tiinamaija Tuomi, Bo Isomaa, Kristina Bengtsson, Johannah L Butler, Richard S Cooper, Caroline S Fox, Christopher J O'Donnell, Caren Vollmert, Juan C Celedón, H Erich Wichmann, Johannes Hebebrand, Kari Stefansson, Christoph Lange, Joel N Hirschhorn
Publikováno v:
PLoS Genetics, Vol 3, Iss 4, p e61 (2007)
A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI) by Herbert and colleagues. The association between increased BMI and homozygosity for the minor allele was first obser
Externí odkaz:
https://doaj.org/article/dc06c9849c15436a9b60607b9319ceeb
Autor:
Robert K. Montgomery, Samuel Tischfield, Jennifer E. Moon, Laurie N. Fishman, Sarah Fleet, Athos Bousvaros, Catarina D. Campbell, Victor L. Fox, Susan S. Baker, Paul Mitchell, Sophie Allende-Richter, Nana Yaa Baffour-Awuah, Johannah L. Butler, Richard J. Grand, Joel N. Hirschhorn, Mikko Kuokkanen
Publikováno v:
Journal of Pediatric Gastroenterology & Nutrition. 60:182-191
Recent data from mainly homogeneous European and African populations implicate a 140-bp region 5' to the transcriptional start site of LCT (the lactase gene) as a regulatory site for lactase persistence and nonpersistence. Because there are no studie
Autor:
Uri Seligsohn, Alkes L. Price, Vincenzo Lorenzo Pascali, Andres Ruiz-Linares, Leif Groop, David Reich, Johannah L. Butler, Penelope Korkolopoulou, Cristian Capelli, Christine Schirmer, Lori Arbeitman, David Goldstein, Alexis Ramos, Alicja Waliszewska, Francesca Scarnicci, Kristin Ardlie, Joel N. Hirschhorn, James Nemesh, Angelica A. Saetta, Nick Patterson
Publikováno v:
PLoS Genetics, Vol 4, Iss 1, p e236 (2008)
European Americans are often treated as a homogeneous group, but in fact form a structured population due to historical immigration of diverse source populations. Discerning the ancestry of European Americans genotyped in association studies is impor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbff29e0fa38a3c500e4d7d9b8967597
https://ora.ox.ac.uk/objects/uuid:40cc23aa-e321-4f5d-9b62-9dffe0dd7023
https://ora.ox.ac.uk/objects/uuid:40cc23aa-e321-4f5d-9b62-9dffe0dd7023
Autor:
Johannah L. Butler, Subra Kugathasan, Joel N. Hirschhorn, Jessica J. Lee, Michael C. Stephens, Richard J. Grand, Marco F. Ramoni, Johanna C. Escher, Guillaume Lettre, Jonah Essers
Publikováno v:
Annals of Human Genetics. 74:489-497
Our data indicate that genetic influences due to stature-associated and possibly CD risk alleles may predispose CD patients to alterations in linear growth. This is the first report of a link between a stature-associated locus and growth impairment i
Autor:
Helen N. Lyon, Rachel Hackett, Xiaofeng Zhu, Ilze Berzins, Johannah L. Butler, Bamidele O. Tayo, Kristin G. Ardlie, Joel N. Hirschhorn, Charleston W. K. Chiang, Richard S. Cooper, Colin A. McKenzie, Rainford J. Wilks, Amy Luke, Candace Guiducci, Guillaume Lettre, Thutrang T. Nguyen, Cameron D. Palmer, Adebowale Adeyemo, Terrence Forrester, Sun J. Kang, Daniel Shriner, Charles N. Rotimi, Tao Feng
Publikováno v:
Human Molecular Genetics. 19:2725-2738
Genome-wide association (GWA) studies have identified common variants that are associated with a variety of traits and diseases, but most studies have been performed in European-derived populations. Here, we describe the first genome-wide analyses of
Autor:
Joel N. Hirschhorn, Sam Tischfield, Laurence N. Kolonel, Christopher A. Haiman, Loic Le Marchand, Brian E. Henderson, Johannah L. Butler, Matthew Egyud, Zofia K. Z. Gajdos
Publikováno v:
Human Genetics. 125:295-303
Many association methods use a subset of genotyped single nucleotide polymorphisms (SNPs) to capture or infer genotypes at other untyped SNPs. We and others previously showed that tag SNPs selected to capture common variation using data from The Inte
Identification of ten loci associated with height highlights new biological pathways in human growth
Autor:
Joel N. Hirschhorn, Frank B. Hu, Serena Sanna, Susana Eyheramendy, Guillaume Lettre, Karen L. Mohlke, Johannah L. Butler, Sonja I. Berndt, Valeriya Lyssenko, Iris M. Heid, Bo Isomaa, Peter Kraft, Michael Boehnke, Stephen J. Chanock, Veikko Salomaa, Anne U. Jackson, H-Erich Wichmann, Leif Groop, Rachel Hackett, Leena Peltonen, Thomas Illig, Gonçalo R. Abecasis, Candace Guiducci, David J. Hunter, Fredrick R. Schumacher, Christian Gieger, Kevin B. Jacobs, Richard B. Hayes, David Schlessinger, Benjamin F. Voight, Manuela Uda
Publikováno v:
Nature Genetics. 40:584-591
Height is a classic polygenic trait, reflecting the combined influence of multiple as-yet-undiscovered genetic factors. We carried out a meta-analysis of genome-wide association study data of height from 15,821 individuals at 2.2 million SNPs, and fo
Autor:
George Dedoussis, Scott T. Weiss, Xiao Ding, Valur Emilsson, Cliona Molony, Constantina Papoutsakis, Juan C. Celedón, Benjamin A. Raby, H.-Erich Wichmann, Manuel E. Soto-Quiros, Gudmar Thorleifsson, Eric E. Schadt, Unnur Thorsteinsdottir, Lydiana Avila, Caren Vollmert, Caroline S. Fox, Nan M. Laird, Florian Kronenberg, Ross Lazarus, Barbara J. Klanderman, Thomas Illig, Iris M. Heid, Jessica Lasky-Su, Helen N. Lyon, Christoph Lange, Joel N. Hirschhorn, Daniel Levy, Christopher J. O'Donnell, Matthew B. McQueen, Kari Stefansson, Kristin G. Ardlie, Johannah L. Butler, Edwin K. Silverman
Publikováno v:
The American Journal of Human Genetics. 82:849-858
The failure of researchers to replicate genetic-association findings is most commonly attributed to insufficient statistical power, population stratification, or various forms of between-study heterogeneity or environmental influences.(1) Here, we il