Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Johanna Zerbib"'
Autor:
Johanna Zerbib, Marica Rosaria Ippolito, Yonatan Eliezer, Giuseppina De Feudis, Eli Reuveni, Anouk Savir Kadmon, Sara Martin, Sonia Viganò, Gil Leor, James Berstler, Julia Muenzner, Michael Mülleder, Emma M. Campagnolo, Eldad D. Shulman, Tiangen Chang, Carmela Rubolino, Kathrin Laue, Yael Cohen-Sharir, Simone Scorzoni, Silvia Taglietti, Alice Ratti, Chani Stossel, Talia Golan, Francesco Nicassio, Eytan Ruppin, Markus Ralser, Francisca Vazquez, Uri Ben-David, Stefano Santaguida
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Aneuploidy is a hallmark of human cancer, yet the molecular mechanisms to cope with aneuploidy-induced cellular stresses remain largely unknown. Here, we induce chromosome mis-segregation in non-transformed RPE1-hTERT cells and derive multip
Externí odkaz:
https://doaj.org/article/39fb3782127942b7a41803d50388bb0d
Autor:
Roy Rabinowitz, Oded Shor, Johanna Zerbib, Shay Herman, Natalie Zelikson, Shreyas Mediwale, Nataly Yom-Tov, Uri Ben-David, Felix Benninger, Daniel Offen
The CRISPR-Cas system holds great promise in the treatment of diseases caused by genetic variations. As wildtype SpyCas9 is known to generate many off-target effects, its use in the clinic remains an elusive goal. To date, several high-fidelity Cas9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdc4856f77de998dc14345772abdc5cb
https://doi.org/10.1101/2023.04.11.536265
https://doi.org/10.1101/2023.04.11.536265
Autor:
Marica Rosaria Ippolito, Johanna Zerbib, Yonatan Eliezer, Eli Reuveni, Sonia Viganò, Giuseppina De Feudis, Anouk Savir Kadmon, Ilaria Vigorito, Sara Martin, Kathrin Laue, Yael Cohen-Sharir, Simone Scorzoni, Francisca Vazquez, Stefano Santaguida, Uri Ben-David
Aneuploidy, an abnormal chromosome composition, results in a stoichiometric imbalance of protein complexes, which jeopardizes the fitness of aneuploid cells. Aneuploid cells thus need to compensate for the imbalanced DNA levels by regulating their RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d18fb3abaa4827fc89c783f62141cbda
https://doi.org/10.1101/2023.01.27.525826
https://doi.org/10.1101/2023.01.27.525826
Autor:
Johanna Zerbib, Marica Rosaria Ippolito, Yonatan Eliezer, Giuseppina De Feudis, Eli Reuveni, Anouk Savir Kadmon, Sara Martin, Sonia Viganò, Gil Leor, James Berstler, Kathrin Laue, Yael Cohen-Sharir, Simone Scorzoni, Francisca Vazquez, Uri Ben-David, Stefano Santaguida
Aneuploidy is a hallmark of human cancer, yet the cellular mechanisms that allow cells to cope with aneuploidy-induced cellular stresses remain largely unknown. Such coping mechanisms may present cellular vulnerabilities that can be harnessed for tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55d6dfffbbebdc391fabd111e83f8a20
https://doi.org/10.1101/2023.01.27.525822
https://doi.org/10.1101/2023.01.27.525822
Autor:
Johanna Zerbib, Daniel Aberdam, Edward Pichinuk, Elie Frank, Léa Zennaro, Keren Oved, Orly Dorot, Lauriane N. Roux, Dominique Bremond-Gignac
Publikováno v:
Biochemical and Biophysical Research Communications. 582:100-104
Aniridia is a panocular inherited rare eye disease linked to heterozygous mutations on the PAX6 gene, which fail to properly produce sufficient protein essential for normal eye development and function. Most of the patients suffer from aniridia-relat
Autor:
Sara Martin, René Wardenaar, Marica Rosaria Ippolito, Daniele Fachinetti, Valentino Martis, Floris Foijer, Uri Ben-David, Stefano Santaguida, Andréa E. Tijhuis, Christy Hong, Diana C.J. Spierings, Marie Dumont, Johanna Zerbib
Publikováno v:
Developmental Cell, 56(17), 2440-2454. CELL PRESS
Mitotic errors lead to aneuploidy, a condition of karyotype imbalance, frequently found in cancer cells. Alterations in chromosome copy number induce a wide variety of cellular stresses, including genome instability. Here, we show that cancer cells m
Akademický článek
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Autor:
Zuzana Storchova, Lisa-Marie Stautmeister, Kathrin Laue, Nicholas J. Lyons, Mariya Kazachkova, Todd R. Golub, Andrew Jones, Stefano Santaguida, Sara Vanessa Bernhard, Jason Stumpff, Helen Tang, Marica Rosaria Ippolito, James M. McFarland, Adam J. Bass, Rameen Beroukhim, Uri Ben-David, Yael Cohen-Sharir, Irena Bockaj, Ankur K. Nagaraja, Carolyn Marquis, Diana C.J. Spierings, Mai Abdusamad, Floris Foijer, Heidi L.H. Malaby, Johanna Zerbib, René Wardenaar
Publikováno v:
Nature, 590(7846). Nature Publishing Group
Nature
Nature
Selective targeting of aneuploid cells is an attractive strategy for cancer treatment(1). However, it is unclear whether aneuploidy generates any clinically relevant vulnerabilities in cancer cells. Here we mapped the aneuploidy landscapes of about 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::632fb9544da6ff2088c466a916cf5a86
https://research.rug.nl/en/publications/6435240d-9c09-4249-b11f-a46eeb586ffb
https://research.rug.nl/en/publications/6435240d-9c09-4249-b11f-a46eeb586ffb
Autor:
Valentino Martis, Floris Foijer, Diana C.J. Spierings, Uri Ben-David, Stefano Santaguida, René Wardenaar, Marica Rosaria Ippolito, Johanna Zerbib, Christy Hong
Mitotic errors lead to aneuploidy, a condition of karyotype imbalance, frequently found in cancer cells. Alterations in chromosome copy number induce a wide variety of cellular stresses, including genome instability. Here, we show that cancer cells m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::577db304e9939e3aa0fa85a27457be92
https://doi.org/10.1101/2020.09.25.313924
https://doi.org/10.1101/2020.09.25.313924
Autor:
Floris Foijer, Valentino Martis, Stefano Santaguida, Johanna Zerbib, René Wardenaar, Uri Ben-David, Christy Hong, Marica Rosaria Ippolito, Diana C.J. Spierings
Publikováno v:
SSRN Electronic Journal.
Mitotic errors lead to aneuploidy, a condition of karyotype imbalance, frequently found in cancer cells. Alterations in chromosome copy number induce a wide variety of cellular stresses, including genome instability. Here, we show that cancer cells m