Zobrazeno 1 - 10
of 224
pro vyhledávání: '"Johanna Weiss"'
Autor:
Camilo Scherkl, Andreas D. Meid, Sven E. Cuntz, Laura Classen, Johanna Weiss, David Czock, Walter E. Haefeli
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 3, Pp n/a-n/a (2024)
Abstract Individual sirolimus whole blood concentrations are highly variable, critically influenced by the concomitant use of cytochrome P450 (CYP) 3A inducers or inhibitors, and also modulated by food. Therapeutic drug monitoring is therefore recomm
Externí odkaz:
https://doaj.org/article/29aa79bdc38c451f872ab11996092463
Autor:
Gzona Bajraktari-Sylejmani, Cindy Bay, Lukas Gebauer, Jürgen Burhenne, Johanna Weiss, Max Sauter
Publikováno v:
Molecules, Vol 29, Iss 21, p 5162 (2024)
Metformin is the gold standard substrate for evaluating potential inhibitors of the organic cation transporters (OCTs). Here, we established a UPLC-MS/MS assay to quantify metformin in cell pellets with a range of 0.05–50 ng/mL using 6-deuterated m
Externí odkaz:
https://doaj.org/article/8431ee4b99bd46bab864944b4a179af1
Autor:
Fabian Rose, Beate Köberle, Sebastian Honnen, Cindy Bay, Jürgen Burhenne, Johanna Weiss, Walter E. Haefeli, Dirk Theile
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 173, Iss , Pp 116450- (2024)
Cisplatin not only targets DNA but also RNA. However, it is largely unknown whether platinated RNA (Pt-RNA) causes apoptosis and thus contributes to the cytotoxic effects of cisplatin. Consequently, cellular RNA was isolated from HepG2 and LS180 cell
Externí odkaz:
https://doaj.org/article/691ee0e015794113952a9066ccf52ae9
Autor:
Juan Pablo Rigalli, Anna Gagliardi, Klara Diester, Gzona Bajraktari-Sylejmani, Antje Blank, Jürgen Burhenne, Alexander Lenard, Lars Werntz, Andrea Huppertz, Lena Münch, Janica Margrit Wendt, Max Sauter, Walter Emil Haefeli, Johanna Weiss
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 4118 (2024)
Drug efflux transporters of the ATP-binding-cassette superfamily play a major role in the availability and concentration of drugs at their site of action. ABCC2 (MRP2) and ABCG2 (BCRP) are among the most important drug transporters that determine the
Externí odkaz:
https://doaj.org/article/da5d043a05534d599854f1f5ffae0d8b
Publikováno v:
BioTechniques, Vol 73, Iss 3, Pp 131-135 (2022)
Experimental data with cells often require normalization. The frequently used bicinchoninic acid (BCA) assay, in fact, indicates protein content but is influenced by incubation time, pH etc. A simple, rapid and reliable alternative is desirable. Crys
Externí odkaz:
https://doaj.org/article/a69fa2ca032848b2abec9388b54d5030
Autor:
Vanessa Zhu, Jürgen Burhenne, Johanna Weiss, Mathias Haag, Ute Hofmann, Matthias Schwab, Stephan Urban, Gerd Mikus, David Czock, Walter E. Haefeli, Antje Blank
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Bulevirtide is a first-in-class antiviral drug to treat chronic hepatitis B/D. We investigated the drug-drug interaction potential and pharmacokinetics of high-dose subcutaneous bulevirtide (5 mg twice daily) with organic anion transpor
Externí odkaz:
https://doaj.org/article/9dadd7a5884e42199ebe15eb6e6fa246
Autor:
Anna Gagliardi, Gzona Bajraktari-Sylejmani, Elisabetta Barocelli, Johanna Weiss, Juan Pablo Rigalli
Publikováno v:
Life, Vol 13, Iss 8, p 1745 (2023)
Drug-metabolizing enzymes (DMEs) and transporters play a major role in drug efficacy and safety. They are regulated at multiple levels and by multiple factors. Estimating their expression and activity could contribute to predicting drug pharmacokinet
Externí odkaz:
https://doaj.org/article/142974420a2d45979a94afb9bea5d278
Autor:
Caterina Prelli Bozzo, Rayhane Nchioua, Meta Volcic, Lennart Koepke, Jana Krüger, Desiree Schütz, Sandra Heller, Christina M. Stürzel, Dorota Kmiec, Carina Conzelmann, Janis Müller, Fabian Zech, Elisabeth Braun, Rüdiger Groß, Lukas Wettstein, Tatjana Weil, Johanna Weiß, Federica Diofano, Armando A. Rodríguez Alfonso, Sebastian Wiese, Daniel Sauter, Jan Münch, Christine Goffinet, Alberto Catanese, Michael Schön, Tobias M. Boeckers, Steffen Stenger, Kei Sato, Steffen Just, Alexander Kleger, Konstantin M. J. Sparrer, Frank Kirchhoff
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
IFITM proteins can inhibit several viruses, but effects on SARS-CoV-2 infection are not well understood. Here, the authors show that endogenous IFITMs support SARS-CoV-2 infection in different in vitro models by binding spike and enhancing virus entr
Externí odkaz:
https://doaj.org/article/45486c77950d4620853ea7ad4237e600
Autor:
Barbara-ann Guinn, Patrick J. Schuler, Hubert Schrezenmeier, Susanne Hofmann, Johanna Weiss, Christiane Bulach, Marlies Götz, Jochen Greiner
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9285 (2023)
Immune checkpoint inhibitors can block inhibitory molecules on the surface of T cells, switching them from an exhausted to an active state. One of these inhibitory immune checkpoints, programmed cell death protein 1 (PD-1) is expressed on T cell subp
Externí odkaz:
https://doaj.org/article/68f05d842e334c0fb2f9bc4f2769c710
Autor:
Cindy Bay, Gzona Bajraktari-Sylejmani, Walter E. Haefeli, Jürgen Burhenne, Johanna Weiss, Max Sauter
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 5029 (2023)
The authors would like to make the following corrections to the publication [...]
Externí odkaz:
https://doaj.org/article/2dda890622dc4a8490397d8346bd4792