Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Johanna Ten, Hoeve"'
Autor:
Amelia Palermo, Shen Li, Johanna ten Hoeve, Akshay Chellappa, Alexandra Morris, Barbara Dillon, Feiyang Ma, Yijie Wang, Edward Cao, Byourak Shabane, Rebeca Acín-Perez, Anton Petcherski, A. Jake Lusis, Stanley Hazen, Orian S. Shirihai, Matteo Pellegrini, Vaithilingaraja Arumugaswami, Thomas G. Graeber, Arjun Deb
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract The ketogenic diet (KD) has demonstrated benefits in numerous clinical studies and animal models of disease in modulating the immune response and promoting a systemic anti-inflammatory state. Here we investigate the effects of a KD on system
Externí odkaz:
https://doaj.org/article/cd9018672742454ebef2fb4e64d4f1fd
Autor:
Kun Do Rhee, Yanjie Wang, Johanna ten Hoeve, Linsey Stiles, Thao Thi Thu Nguyen, Xiangmei Zhang, Laurent Vergnes, Karen Reue, Orian Shirihai, Dean Bok, Xian-Jie Yang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Rhee et al. demonstrates that the potent neuroprotective agent CNTF significantly impacts metabolism of degenerating retinas, thus revealing cellular mechanisms underlying enhanced neuronal viability and providing insight for the ongoing CNTF clinica
Externí odkaz:
https://doaj.org/article/2f8c15a86a74474882c082f8c3e059f3
Autor:
Neal K Bennett, Hiroki J Nakaoka, Danny Laurent, Ross A Okimoto, Yoshitaka Sei, Andrew E Horvai, Trever G Bivona, Johanna Ten Hoeve, Thomas G Graeber, Ken Nakamura, Jean L Nakamura
Publikováno v:
PLoS Biology, Vol 20, Iss 9, p e3001753 (2022)
The Warburg effect, aerobic glycolysis, is a hallmark feature of cancer cells grown in culture. However, the relative roles of glycolysis and respiratory metabolism in supporting in vivo tumor growth and processes such as tumor dissemination and meta
Externí odkaz:
https://doaj.org/article/fe3de3a23f7743958aa4f1af96582889
Autor:
Neal K. Bennett, Mai K. Nguyen, Maxwell A. Darch, Hiroki J. Nakaoka, Derek Cousineau, Johanna ten Hoeve, Thomas G. Graeber, Markus Schuelke, Emin Maltepe, Martin Kampmann, Bryce A. Mendelsohn, Jean L. Nakamura, Ken Nakamura
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Energy metabolism and ATP levels are controlled by an interlocking network of pathways. Here, the authors apply a genome-wide CRISPR screen to define genes that increase or decrease ATP levels to define the “ATPome”, a map of pathways that contri
Externí odkaz:
https://doaj.org/article/f277e255c7dc4504b568ae47fe3e9af8
Autor:
Shen Li, Tomohiro Yokota, Ping Wang, Johanna ten Hoeve, Feiyang Ma, Thuc M. Le, Evan R. Abt, Yonggang Zhou, Rimao Wu, Maxine Nanthavongdouangsy, Abraham Rodriguez, Yijie Wang, Yen-Ju Lin, Hayato Muranaka, Mark Sharpley, Demetrios T. Braddock, Vicky E. MacRae, Utpal Banerjee, Pei-Yu Chiou, Marcus Seldin, Dian Huang, Michael Teitell, Ilya Gertsman, Michael Jung, Steven J. Bensinger, Robert Damoiseaux, Kym Faull, Matteo Pellegrini, Aldons J. Lusis, Thomas G. Graeber, Caius G. Radu, Arjun Deb
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 2 (2022)
Various populations of cells are recruited to the heart after cardiac injury, but little is known about whether cardiomyocytes directly regulate heart repair. Using a murine model of ischemic cardiac injury, we demonstrate that cardiomyocytes play a
Externí odkaz:
https://doaj.org/article/4f249dd668874f6a904b120bd8b43144
Autor:
Shen Li, Feiyang Ma, Tomohiro Yokota, Gustavo Garcia Jr., Amelia Palermo, Yijie Wang, Colin Farrell, Yu-Chen Wang, Rimao Wu, Zhiqiang Zhou, Calvin Pan, Marco Morselli, Michael A. Teitell, Sergey Ryazantsev, Gregory A. Fishbein, Johanna ten Hoeve, Valerie A. Arboleda, Joshua Bloom, Barbara Dillon, Matteo Pellegrini, Aldons J. Lusis, Thomas G. Graeber, Vaithilingaraja Arumugaswami, Arjun Deb
Publikováno v:
JCI Insight, Vol 6, Iss 2 (2021)
Extrapulmonary manifestations of COVID-19 are associated with a much higher mortality rate than pulmonary manifestations. However, little is known about the pathogenesis of systemic complications of COVID-19. Here, we create a murine model of SARS-Co
Externí odkaz:
https://doaj.org/article/5eccd2b0db0941ecae1137cd886d2357
Autor:
Nicholas A Graham, Aspram Minasyan, Anastasia Lomova, Ashley Cass, Nikolas G Balanis, Michael Friedman, Shawna Chan, Sophie Zhao, Adrian Delgado, James Go, Lillie Beck, Christian Hurtz, Carina Ng, Rong Qiao, Johanna ten Hoeve, Nicolaos Palaskas, Hong Wu, Markus Müschen, Asha S Multani, Elisa Port, Steven M Larson, Nikolaus Schultz, Daniel Braas, Heather R Christofk, Ingo K Mellinghoff, Thomas G Graeber
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 2, Pp 1-25 (2017)
Abstract Copy number alteration (CNA) profiling of human tumors has revealed recurrent patterns of DNA amplifications and deletions across diverse cancer types. These patterns are suggestive of conserved selection pressures during tumor evolution but
Externí odkaz:
https://doaj.org/article/ecca9cc2cad345a0a0b562644ca81d88
Autor:
Thomas G. Graeber, Roger S. Lo, Vineet Bafna, Daniel S. Peeper, Asha S. Multani, P. Nagesh Rao, Paul J. Hergenrother, Kim H. Paraiso, T. Niroshi Senaratne, Stephen E. Motika, Amelia Palermo, Johanna ten Hoeve, Kyle Sheu, Salwan Alhani, Nikolas G. Balanis, Rachana Jayaraman, Gabriel Karin, Eli Pazol, Jesus Salazar, William P. Crosson, Trevor Ridgley, Prashanthi Dharanipragada, Oscar Krijgsman, Gatien Moriceau, Mark H. Goodman, Jens Luebeck, Shirley H. Lomeli, Siavash R. Dehkordi, Arthur Huang, Jenna K. Minami, Kai Song
Focal amplifications (FA) can mediate targeted therapy resistance in cancer. Understanding the structure and dynamics of FAs is critical for designing treatments that overcome plasticity-mediated resistance. We developed a melanoma model of dual MAPK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005496410afa192ef817de39cbb29907
https://doi.org/10.1158/2159-8290.c.6549616.v1
https://doi.org/10.1158/2159-8290.c.6549616.v1
Autor:
Thomas G. Graeber, Roger S. Lo, Vineet Bafna, Daniel S. Peeper, Asha S. Multani, P. Nagesh Rao, Paul J. Hergenrother, Kim H. Paraiso, T. Niroshi Senaratne, Stephen E. Motika, Amelia Palermo, Johanna ten Hoeve, Kyle Sheu, Salwan Alhani, Nikolas G. Balanis, Rachana Jayaraman, Gabriel Karin, Eli Pazol, Jesus Salazar, William P. Crosson, Trevor Ridgley, Prashanthi Dharanipragada, Oscar Krijgsman, Gatien Moriceau, Mark H. Goodman, Jens Luebeck, Shirley H. Lomeli, Siavash R. Dehkordi, Arthur Huang, Jenna K. Minami, Kai Song
Supplementary Table from Plasticity of Extrachromosomal and Intrachromosomal BRAF Amplifications in Overcoming Targeted Therapy Dosage Challenges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a8c4bd05ca644172e944aa05c3ccc9
https://doi.org/10.1158/2159-8290.22541326
https://doi.org/10.1158/2159-8290.22541326
Autor:
Thomas G. Graeber, Roger S. Lo, Vineet Bafna, Daniel S. Peeper, Asha S. Multani, P. Nagesh Rao, Paul J. Hergenrother, Kim H. Paraiso, T. Niroshi Senaratne, Stephen E. Motika, Amelia Palermo, Johanna ten Hoeve, Kyle Sheu, Salwan Alhani, Nikolas G. Balanis, Rachana Jayaraman, Gabriel Karin, Eli Pazol, Jesus Salazar, William P. Crosson, Trevor Ridgley, Prashanthi Dharanipragada, Oscar Krijgsman, Gatien Moriceau, Mark H. Goodman, Jens Luebeck, Shirley H. Lomeli, Siavash R. Dehkordi, Arthur Huang, Jenna K. Minami, Kai Song
Supplementary Figure from Plasticity of Extrachromosomal and Intrachromosomal BRAF Amplifications in Overcoming Targeted Therapy Dosage Challenges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ca04ff69af6e06a7f3fc1472e95733
https://doi.org/10.1158/2159-8290.22541341
https://doi.org/10.1158/2159-8290.22541341