Effect of elevating the skin temperature during topical ALA application on in vitro ALA penetration through mouse skin and in vivo PpIX production in human skin

Autor: Johanna T. H. M. van den Akker, Stanley B. Brown, Henricus J. C. M. Sterenborg, Laurens Groenendijk, David I. Vernon, Gerard C. van Rhoon, Kristian Boot

Publikováno v: Photochemical & photobiological sciences, 3(3), 263-267. Royal Society of Chemistry
Photochemical & Photobiological Sciences, 263(7), 1-2. Royal Society of Chemistry

An approach to induce increased protoporphyrin IX (PpIX) production in aminolevulinic acid (ALA)-based photodynamic therapy (PDT) of skin lesions is to elevate the skin temperature during topical ALA application. Increased skin temperature may increa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29cdb205f0b319350358a1ca107e7d9
https://doi.org/10.1039/b309284d

Systemic component of protoporphyrin IX production in nude mouse skin upon topical application of aminolevulinic acid depends on the application conditions

Autor: Johan Emelian Moan, Henricus J. C. M. Sterenborg, Vladimir Iani, Johanna T. H. M. van den Akker, Willem M. Star

Publikováno v: Photochemistry and photobiology, 75(2), 172-177. Wiley-Blackwell

Topical application of 5-aminolevulinic acid (ALA) for protoporphyrin IX (PpIX)-based photodynamic therapy of skin cancer is generally considered not to induce systemic side effects because PpIX is supposed to be formed locally. However, earlier stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::319354ab89d879fbf92691e5297918b0
https://doi.org/10.1562/0031-8655(2002)075<0172:scopip>2.0.co

Comparative in vitro percutaneous penetration of 5-aminolevulinic acid and two of its esters through excised hairless mouse skin

Autor: Johanna T. H. M. van den Akker, Henricus J. C. M. Sterenborg, David I. Vernon, Stanley B. Brown, J. Andrew Holroyd

Publikováno v: Lasers in surgery and medicine, 33(3), 173-181. Wiley-Liss Inc.
Lasers in Surgery and Medicine, 33, 173-181. Wiley-Liss Inc.

Background and Objectives ALA esters have been developed to improve PpIX production in ALA–PDT, but they do not perform as well in skin as they do in cells and the bladder. Study Design/Materials and Methods The in vitro penetration across normal m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c926c8d1c66272dc9954e959989736e
https://pubmed.ncbi.nlm.nih.gov/12949947

Protoporphyrin IX Fluorescence Kinetics and Localization after Topical Application of ALA Pentyl Ester and ALA on Hairless Mouse Skin with UVB-Induced Early Skin Cancer

Autor: Henricus J. C. M. Sterenborg, Willem M. Star, Johanna T. H. M. van den Akker, Henriëtte S. de Bruijn, Gerard M. J. Beijersbergen van Henegouwen

Publikováno v: Photochemistry and photobiology, 72(3), 399-406. Wiley-Blackwell

In order to improve the efficacy of 5-aminolevulinic acid-based (ALA) photodynamic therapy (PDT), different ALA derivatives are presently being investigated. ALA esters are more lipophilic and therefore may have better skin penetration properties tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::853554a8a77ea35dd466d62c329081ef
https://doi.org/10.1562/0031-8655(2000)072<0399:pifkal>2.0.co