Výsledky vyhledávání - "Johanna Smeekens"

The airway as a route of sensitization to peanut: An update to the dual allergen exposure hypothesis

Autor: Michael D. Kulis, Johanna Smeekens, Timothy P. Moran, Robert M. Immormino

Publikováno v: J Allergy Clin Immunol

Food allergies have increased at an alarming rate over the past 2 decades, indicating that environmental factors are driving disease progression. It has been postulated that sensitization to foods, in particular, peanut, occurs through impaired skin.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75e71ada2474a4fdc64422ebf0f208b
https://doi.org/10.1016/j.jaci.2021.05.035

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Peanut applied to the skin of nonhuman primates induces antigen‐specific IgG but not IgE

Autor: Michael D. Kulis, Johanna Smeekens, Matthew J. Jorgensen, Kylie Kavanagh

Publikováno v: Immunity, Inflammation and Disease, Vol 8, Iss 2, Pp 211-215 (2020)
Immunity, Inflammation and Disease

Introduction Previous studies in humans support the dual‐allergen exposure hypothesis, and several studies in mouse models have demonstrated that cutaneous exposure to disrupted or intact skin can lead to sensitization to peanut. However, the field

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744f80e18f0b947709e53115354d8f62
https://doaj.org/article/eb775adec6904ec1857669380e175745

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Evolution of Immune Responses in Food Immunotherapy

Autor: Michael D. Kulis, Johanna Smeekens

Publikováno v: Immunol Allergy Clin North Am

Food allergies are a growing public health concern affecting approximately 8% of children and 10% of adults in the United States. Several immunotherapy approaches are under active investigation, including oral immunotherapy, epicutaneous immunotherap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea80d38e317a60871bb529b278b01d1c
https://doi.org/10.1016/j.iac.2019.09.006

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Increased intestinal permeability in an orally-reactive peanut allergy model identifies Angiopoietin like-4 as a biomarker

Autor: Satyaki Roy, Burks Aw, Johanna Smeekens, Erin C. Steinbach, Kulis, Shehzad Z. Sheikh, Ana Berglind, Takahiko Toyonaga, Perini Lb, Martin T. Ferris, Edwin H. Kim, Cornaby C, Terrence S. Furey

Peanut allergy reaction severity correlates with increased intestinal epithelial cell (IEC) barrier permeability. CC027/GeniUnc mice develop peanut allergy by intragastric administration of peanut proteins without adjuvant. We report that peanut-alle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4f1746eae04d5b19695ce65edd55c67
https://doi.org/10.1101/2021.07.14.452416

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Indoor dust acts as an adjuvant to promote sensitization to peanut through the airway

Autor: Michael D. Kulis, Johanna Smeekens, Peter A Balogh, Scott H. Randell, Timothy P. Moran, Robert M. Immormino

Publikováno v: Clin Exp Allergy

Background There is growing evidence that environmental peanut exposure through non-oral routes, including the skin and respiratory tract, can result in peanut sensitization. Environmental adjuvants in indoor dust can promote sensitization to inhaled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::911323951d3ab5d50ddf7adac42d3566
https://doi.org/10.1111/cea.13486

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