Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Johanna Shen"'
Autor:
Ann-Marie K. Shorrocks, Samuel E. Jones, Kaima Tsukada, Carl A. Morrow, Zoulikha Belblidia, Johanna Shen, Iolanda Vendrell, Roman Fischer, Benedikt M. Kessler, Andrew N. Blackford
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The BLM helicase interacts with the topoisomerase TOP3A and RMI1 to form the BTR complex. Here, the authors reveal that this complex contains multiple binding sites for the single-stranded DNA-binding complex RPA, and that RPA-binding stimulates BLM
Externí odkaz:
https://doaj.org/article/b8e899d3fab949ef9615c88f13f058e9
Autor:
Matthew B. Dong, Kaiyuan Tang, Xiaoyu Zhou, Johanna Shen, Krista Chen, Hyunu R. Kim, Jerry Zhou, Hanbing Cao, Erica Vandenbulcke, Yueqi Zhang, Ryan D. Chow, Andrew Du, Kazushi Suzuki, Shao-Yu Fang, Medha Majety, Xiaoyun Dai, Sidi Chen
Publikováno v:
bioRxiv
SummaryCas9 transgenic animals have drastically accelerated the discovery of novel immune modulators. But due to its inability to process its own CRISPR RNAs (crRNAs), simultaneous multiplexed gene perturbations using Cas9 remains limited, especially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd2f3c9fe5579ba654d0138ae9da2021
https://doi.org/10.1101/2023.03.14.532657
https://doi.org/10.1101/2023.03.14.532657
Publikováno v:
Nature biomedical engineering
Prime editing enables diverse genomic alterations to be written into target sites without requiring double-strand breaks or donor templates. The design of prime-editing guide RNAs (pegRNAs), which must be customized for each edit, can however be comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056edf9c2482d7a0fe15385a92365d5f
https://doi.org/10.1038/s41551-020-00622-8
https://doi.org/10.1038/s41551-020-00622-8
To the EditorCRISPR technologies have been widely adopted as powerful tools for targeted genomic manipulation 1. Recently, a new CRISPR-based strategy for precision genome editing was developed that enables diverse genomic alterations to be directly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3512ec1d7984725a8f9f802623853203
https://doi.org/10.1101/2020.05.06.081612
https://doi.org/10.1101/2020.05.06.081612
Autor:
Stanley Z. Lam, Yaying Du, Xiaoyun Dai, Christopher D. Guzman, Xiaoyu Zhou, Sidi Chen, Jonathan J. Park, Donald R. Lannin, Guangchuan Wang, Hyunu Ray Kim, Lupeng Ye, Jingjia J. Zhou, Matthew B. Dong, Roy S. Herbst, Paul A. Renauer, Ryan D. Chow, Lvyun Zhu, Krista Y. Chen, Youssef Errami, Johanna Shen
Publikováno v:
Cell
CD8 T cells play essential roles in anti-tumor immune responses. Here, we performed genome-scale CRISPR screens in CD8 T cells directly under cancer immunotherapy settings, and identified regulators of tumor infiltration and degranulation. The in viv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17853f8e1bc5359c1819139e43ee3f8c
https://pubmed.ncbi.nlm.nih.gov/31492928
https://pubmed.ncbi.nlm.nih.gov/31492928