Increased sensitivity to broadly neutralizing antibodies of end-stage disease R5 HIV-1 correlates with evolution in Env glycosylation and charge.

Autor: Marie Borggren, Johanna Repits, Jasminka Sterjovski, Hannes Uchtenhagen, Melissa J Churchill, Anders Karlsson, Jan Albert, Adnane Achour, Paul R Gorry, Eva Maria Fenyö, Marianne Jansson

Publikováno v: PLoS ONE, Vol 6, Iss 6, p e20135 (2011)

BACKGROUND: Induction of broadly neutralizing antibodies, such as the monoclonal antibodies IgGb12, 2F5 and 2G12, is the objective of most antibody-based HIV-1 vaccine undertakings. However, despite the relative conserved nature of epitopes targeted

Externí odkaz: https://doaj.org/article/fd270ce1c66d4db6ab54f2a06090e26c

Laboratory Findings, Compassionate Use of Favipiravir, and Outcome in Patients With Ebola Virus Disease, Guinea, 2015-A Retrospective Observational Study

Autor: Babak Afrough, Mar Cabeza-Cabrerizo, Ulrike Arnold, Jonathan H.J. Baum, Lamine Koivogui, Christopher H. Logue, Luam Ghebreghiorghis, Nicole Hetzelt, Katja Nitzsche, Rahel Lemma Yenamaberhan, Cèline Gurry, Daouda Sissoko, Lauren A. Cowley, Ralf Krumkamp, Martin Rudolf, Carlos M. Castro, Kilian Stoecker, Roman Wölfel, Beate Becker-Ziaja, Sophie Duraffour, Inês Vitoriano, Isabel García-Dorival, Erna Fleischmann, Natasha Y. Rickett, Antonino Di Caro, Marc Mertens, Joseph Akoi Bore, Sarah Meisel, Theresa Enkirch, Sékou Ditinn Cissé, Liana E. Kafetzopoulou, Anna Jaeger, Martin Gabriel, Abigail Kosgei, Fara Raymond Koundouno, Lisa L. Carter, Boubacar Diallo, N’Faly Magassouba, Jürgen May, Tobias Holm, Johanna Repits, Katrin Singethan, Julia Hinzmann, Denis Malvy, Elisa Pallasch, Xavier Anglaret, Stephanie Wurr, Patrick Drury, Antonio Mazzarelli, Eva Lorenz, Sakoba Keita, Claire Levy Marchal, Osvaldo Miranda, Alseny-Modet Camara, Romy Kerber, Géraldine Colin, Sylvain Juchet, Jacques Seraphin Kolié, Stephan Günther, Miles W. Carroll, Abdoul Habib Beavogui, Sabrina Bockholt, Pierre Formenty, Janine Michel, Alvaro Camino, Eeva Kuisma, Giuseppe Ippolito, Livia Victoria Patrono, Andreas Sachse, Jan-Peter Böttcher, Amadou Bah, Elsa Gayle Zekeng, Jasmine Portmann

Publikováno v: JOURNAL OF INFECTIOUS DISEASES
Journal of Infectious Diseases
Journal of Infectious Diseases, Oxford University Press (OUP), 2019, 220 (2), pp.195-202. ⟨10.1093/infdis/jiz078⟩
The Journal of Infectious Diseases

In 2015, favipiravir was administered on a compassionate-use basis to patients with Ebola virus disease in Guinea. This study reveals a trend toward improved survival in favipiravir-treated patients; however, the effect of treatment was not statistic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82b8acb3a37901ef1f93dc953e3b506

Reduced Baseline Sensitivity to Maraviroc Inhibition Among R5 HIV-1 Isolates From Individuals With Severe Immunodeficiency

Autor: Magnus Gisslén, Martin Ålenius, Ulf O. Karlsson, Johanna Repits, Joakim Esbjörnsson, Marianne Jansson, Erik Cederfjäll, Bengt Ljungberg, Alan Sabirsh, Liselotte Antonsson

Publikováno v: Journal of Acquired Immune Deficiency Syndromes (1999)

To the Editors: The recognition that the chemokine receptors CCR5 and CXCR4 act as essential receptors for the entry of human immunodeficiency virus type 1 (HIV-1) into CD4+ target cells has provided the basis for new treatment strategies. Although H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d305242074bb012ea47f46fcd4727094
https://doi.org/10.1097/qai.0000000000000873

Microbial Translocation Correlates with the Severity of Both HIV‐1 and HIV‐2 Infections

Autor: Salma Nowroozalizadeh, Fredrik Månsson, Zacarias da Silva, Johanna Repits, Braima Dabo, Carla Pereira, Antonio Biague, Jan Albert, Jens Nielsen, Peter Aaby, Eva Maria Fenyö, Hans Norrgren, Birgitta Holmgren, Marianne Jansson

Publikováno v: The Journal of Infectious Diseases. 201:1150-1154

Microbial translocation has been linked to systemic immune activation during human immunodeficiency virus (HIV) type 1 infection. Here, we show that an elevated level of microbial translocation, measured as plasma lipopolysaccharide (LPS) concentrati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71ee8e4d8a0b0cd2127c89964d1830a6
https://doi.org/10.1086/651430

Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa

Autor: Eeva Kuisma, Julia Hinzmann, Fabrizio Carletti, Edmund N. C. Newman, Janine Michel, Andreas Sachse, Andreas Kurth, Hilde De Clerck, Yemisi Ighodalo, N’Faly Magassouba, Mandy Kader Kondé, Isabel García-Dorival, Claudia Kohl, Francesca Colavita, Patience Akhilomen, Ruth Thom, Kilian Stoecker, Johanna Repits, Francis Senyah, Emmanuel Omomoh, Ute Hopf-Guevara, Elisa Pallasch, Catherine Pratt, Martin Richter, Gytis Dudas, Erna Fleischmann, Christopher H. Logue, Simone Priesnitz, Lisa Oestereich, Jan Peter Boettcher, Anja Lüdtke, Deborah U. Ehichioya, Tine Vermoesen, Serena Quartu, Heinz Ellerbrok, Mandiou Diakite, Hervé Raoul, Michael J. Elmore, Ekaete Alice Tobin, Raymond Koundouno, Kristina Maria Schmidt, Zoltán Kis, Antje Hermelink, Simon Clark, Miles W. Carroll, Callum Wright, Svenja Wolff, Benny Borremans, Doreen Muth, Silvia Meschi, Peter Molkenthin, Thomas Olokor, Thomas Strecker, Anne Kelterbaum, Simon R. Bate, John Kenny, Sophie Duraffour, Gordian Schudt, César Muñoz-Fontela, Andrew Bosworth, Julie C. F. Rappe, Babak Afrough, Bernadett Pályi, Jennifer Okosun, Martin Gabriel, Amadou Bah, Tatjana Avšič-Županc, Matthias Wagner, Benjamin Meyer, Yper Hall, Constanze Yue, Georgios Pollakis, Sakoba Keita, Britta Liedigk, Sophie Gryseels, Jasmine Portmann, Marlis Badusche, Anne Bocquin, Roman Wölfel, Beate Becker-Ziaja, Stephan Becker, Damien Steer, Romy Kerber, Lamine Koivogui, Sandra Diederich, Piet Maes, Saïd Abdellati, Stefan Kloth, Stephan Günther, Roger Hewson, Adomeh Donatus, Concetta Castilletti, Stephen Thomas, James McCowen, Barry Atkinson, Armand Sprecher, Alexis Traoré, Jochen Trautner, Maria Rosaria Capobianchi, Racheal Omiunu, Thomas Pottage, Jan Baumann, Alexandra Fizet, Giuseppe Ippolito, David A. Matthews, Andrew Rambaut, Patrick Drury, Dirk Becker, Miša Korva, Pierre Formenty, Howard Tolley, Angela Cannas, Birte Kretschmer, Didier Ngabo, Maria Dolores Fernandez-Garcia, Martin Rudolf, Boubacar Diallo, Inês Vitoriano, Marc Mertens, Stéphane Mély, Natasha Y. Rickett, Antonino Di Caro, Joseph Akoi Bore, Annette Kraus, Cordelia E. M. Coltart, Marc Strasser, Julian A. Hiscox, Lisa J. Jameson, Andreas Nitsche, Danny Asogun, Michel Van Herp, John Aiyepada

Publikováno v: Carroll, M W, Matthews, D A, Hiscox, J A, Elmore, M J, Pollakis, G, Rambaut, A, Hewson, R, Garcia-Dorival, I, Bore, J A, Koundouno, R, Abdellati, S, Afrough, B, Aiyepada, J, Akhilomen, P, Asogun, D, Atkinson, B, Badusche, M, Bah, A, Bate, S, Baumann, J, Becker, D, Becker-Ziaja, B, Bocquin, A, Borremans, B, Bosworth, A, Boettcher, J P, Cannas, A, Carletti, F, Castilletti, C, Clark, S, Colavita, F, Diederich, S, Donatus, A, Duraffour, S, Ehichioya, D, Ellerbrok, H, Fenandez-Garcia, M D, Fizet, A, Fleischmann, E, Gryseels, S, Hermelink, A, Hinzmann, J, Hopf-Guevara, U, Ighodalo, Y, Jameson, L, Kelterbaum, A, Kis, Z, Kloth, S, Kohl, C, Korva, M, Kraus, A, Kuisma, E, Kurth, A, Liedigk, B, Logue, C H, Ludtke, A, Maes, P, McCowen, J, Mely, S, Mertens, M, Meschi, S, Meyer, B, Michel, J, Molkenthin, P, Munoz-Fontela, C, Muth, D, Newman, E N C, Ngabo, D, Oestereich, L, Okosun, J, Olokor, T, Omiunu, R, Omomoh, E, Pallasch, E, Palyi, B, Portmann, J, Pottage, T, Pratt, C, Priesnitz, S, Quartu, S, Rappe, J, Repits, J, Richter, M, Rudolf, M, Sachse, A, Schmidt, K M, Schudt, G, Strecker, T, Thom, R, Thomas, S, Tobin, E, Tolley, H, Trautner, J, Vermoesen, T, Vitoriano, I, Wagner, M, Wolff, S, Yue, C, Capobianchi, M R, Kretschmer, B, Hall, Y, Kenny, J G, Rickett, N Y, Dudas, G, Coltart, C E M, Kerber, R, Steer, D, Wright, C, Senyah, F, Keita, S, Drury, P, Diallo, B, de Clerck, H, Van Herp, M, Sprecher, A, Traore, A, Diakite, M, Konde, M K, Koivogui, L, Magassouba, NF, Avsic-Zupanc, T, Nitsche, A, Strasser, M, Ippolito, G, Becker, S, Stoecker, K, Gabriel, M, Raoul, H, Di Caro, A, Wolfel, R, Formenty, P & Gunther, S 2015, ' Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa ', Nature, vol. 524, no. 7563, pp. 97-101 . https://doi.org/10.1038/nature14594
Nature
Carroll, M W, Matthews, D A, Hiscox, J A, Elmore, M J, Pollakis, G, Rambaut, A, Hewson, R, Garcia-Dorival, I, Bore, J A, Koundouno, R, Abdellati, S, Afrough, B, Aiyepada, J, Akhilomen, P, Asogun, D, Atkinson, B, Badusche, M, Bah, A, Bate, S, Baumann, J, Becker, D, Becker-Ziaja, B, Bocquin, A, Borremans, B, Bosworth, A, Boettcher, J P, Cannas, A, Carletti, F, Castilletti, C, Clark, S, Colavita, F, Diederich, S, Donatus, A, Duraffour, S, Ehichioya, D, Ellerbrok, H, Fenandez-Garcia, M D, Fizet, A, Fleischmann, E, Gryseels, S, Hermelink, A, Hinzmann, J, Hopf-Guevara, U, Ighodalo, Y, Jameson, L, Kelterbaum, A, Kis, Z, Kloth, S, Kohl, C, Korva, M, Kraus, A, Kuisma, E, Kurth, A, Liedigk, B, Logue, C H, Ludtke, A, Maes, P, McCowen, J, Mely, S, Mertens, M, Meschi, S, Meyer, B, Michel, J, Molkenthin, P, Munoz-Fontela, C, Muth, D, Newman, E N C, Ngabo, D, Oestereich, L, Okosun, J, Olokor, T, Omiunu, R, Omomoh, E, Pallasch, E, Palyi, B, Portmann, J, Pottage, T, Pratt, C, Priesnitz, S, Quartu, S, Rappe, J, Repits, J, Richter, M, Rudolf, M, Sachse, A, Schmidt, K M, Schudt, G, Strecker, T, Thom, R, Thomas, S, Tobin, E, Tolley, H, Trautner, J, Vermoesen, T, Vitoriano, I, Wagner, M, Wolff, S, Yue, C, Capobianchi, M R, Kretschmer, B, Hall, Y, Kenny, J G, Rickett, N Y, Dudas, G, Coltart, C E M, Kerber, R, Steer, D, Wright, C, Senyah, F, Keita, S, Drury, P, Diallo, B, de Clerck, H, Van Herp, M, Sprecher, A, Traore, A, Diakite, M, Konde, M K, Koivogui, L, Magassouba, N F, Avsic-Zupanc, T, Nitsche, A, Strasser, M, Ippolito, G, Becker, S, Stoecker, K, Gabriel, M, Raoul, H, Di Caro, A, Wolfel, R, Formenty, P & Gunther, S 2015, ' Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa ' Nature, vol 524, no. 7563, pp. 97-101 . DOI: 10.1038/nature14594
Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa. 2015: Nature
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Médecins Sans Frontières Field Research
Lirias

West Africa is currently witnessing the most extensive Ebola virus (EBOV) outbreak so far recorded. Until now, there have been 27,013 reported cases and 11,134 deaths. The origin of the virus is thought to have been a zoonotic transmission from a bat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e654c64b5b83a8ccc95112884cb3fee7
https://lirias.kuleuven.be/handle/123456789/515342