Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Johanna Rankenberg"'
Publikováno v:
Frontiers in Ophthalmology, Vol 3 (2023)
Presbyopia is the progressive loss of the ability of the lens to focus on nearby objects due to its increased stiffness. It occurs in the mid-40s and continues to worsen until the mid-60s. The age-associated increase in protein cross-linking in the l
Externí odkaz:
https://doaj.org/article/5e920941a56f403aa969a84c450ab52a
Autor:
Vivian Rajeswaren, Jeffrey O. Wong, Dana Yabroudi, Rooban B. Nahomi, Johanna Rankenberg, Mi-Hyun Nam, Ram H. Nagaraj
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
This review summarizes the latest findings on small heat shock proteins (sHsps) in three major retinal diseases: glaucoma, diabetic retinopathy, and age-related macular degeneration. A general description of the structure and major cellular functions
Externí odkaz:
https://doaj.org/article/7f07f974e8de494d89f5242ff55631d8
Autor:
Sudipta Panja, Rooban B. Nahomi, Johanna Rankenberg, Cole R. Michel, Hanmant Gaikwad, Mi‐Hyun Nam, Ram H. Nagaraj
Publikováno v:
Aging Cell. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43a18302e7939d96fbd175c32b458fa7
https://doi.org/10.1111/acel.13797
https://doi.org/10.1111/acel.13797
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 2196
Volume 24
Issue 3
Pages: 2196
With aging, human lenses lose the ability to focus on nearby objects due to decreases in accommodative ability, a condition known as presbyopia. An increase in stiffness or decrease in lens elasticity due to protein aggregation and insolubilization a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18730bfc407b5c1ac5ad2e7054f30c33
Publikováno v:
Biochemical Journal. 478:2285-2296
Transforming growth factor-β2 (TGFβ2)-mediated epithelial to mesenchymal transition (EMT) in lens epithelial cells (LECs) has been implicated in fibrosis associated with secondary cataracts. In this study, we investigated whether the receptor for a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08fac7e099e37cd27c2e429d8ad1ca8d
https://doi.org/10.1042/bcj20210069
https://doi.org/10.1042/bcj20210069
Autor:
Johanna Rankenberg, Rooban B. Nahomi, Sandip Kumar Nandi, Marcus A. Glomb, Ram H. Nagaraj, Mikhail Linetsky, Stefan Rakete
Publikováno v:
Glycoconj J
Proteins in the eye lens have negligible turnover and therefore progressively accumulate chemical modifications during aging. Carbonyls and oxidative stresses, which are intricately linked to one another, predominantly drive such modifications. Oxida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0179d57f377a23b732e9d2d09d2c1c1
https://doi.org/10.1007/s10719-020-09961-9
https://doi.org/10.1007/s10719-020-09961-9
Publikováno v:
J Biol Chem
Lens proteins become increasingly cross-linked through nondisulfide linkages during aging and cataract formation. One mechanism that has been implicated in this cross-linking is glycation through formation of advanced glycation end products (AGEs). H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f17d75eaecab918cea41e5b59ef28e49
https://doi.org/10.1074/jbc.ra120.012604
https://doi.org/10.1074/jbc.ra120.012604
Publikováno v:
Biochem Biophys Res Commun
The chaperone activity of α-crystallin is important for maintaining the transparency of the human lens. αB-crystallin (αBC) is a long-lived protein in the lens that accumulates chemical modifications during aging. The formation of advanced glycati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cecc1016888b577dd32083645c07d3a9
https://pubmed.ncbi.nlm.nih.gov/33081971
https://pubmed.ncbi.nlm.nih.gov/33081971
Autor:
Dorota L. Stankowska, Stefan Rakete, Rooban B. Nahomi, Mina B. Pantcheva, Julie A. Houck, Ginger C. Johnson, Paul S. MacLean, Ram H. Nagaraj, Mi Hyun Nam, Johanna Rankenberg
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 5
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1795 (2020)
Volume 21
Issue 5
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1795 (2020)
Background: Glaucoma is an optic neuropathy and involves the progressive degeneration of retinal ganglion cells (RGCs), which leads to blindness in patients. We investigated the role of the neuroprotective kynurenic acid (KYNA) in RGC death against r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a6ac3771a1be9fdfc0e37c07e9ad0d6
http://europepmc.org/articles/PMC7084183
http://europepmc.org/articles/PMC7084183
Autor:
Stefan Rakete, Ram H. Nagaraj, Christian Henning, Jennifer L. Patnaik, Brandie D. Wagner, Johanna Rankenberg, Anne M. Lynch, Marcus A. Glomb
Publikováno v:
Exp Eye Res
Advanced glycation end products (AGEs) accumulate with age in human lens capsules. AGEs in lens capsules potentiate the transforming growth factor beta-2-mediated mesenchymal transition of lens epithelial cells, which suggests that they play a role i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba489a75c0959a71934fc4b12d78049b
https://doi.org/10.1016/j.exer.2021.108704
https://doi.org/10.1016/j.exer.2021.108704