Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Johanna Raithel"'
Autor:
Roger Mulet-Lazaro, Stanley van Herk, Margit Nuetzel, Aniko Sijs-Szabo, Noelia Díaz, Katherine Kelly, Claudia Erpelinck-Verschueren, Lucia Schwarzfischer-Pfeilschifter, Hanna Stanewsky, Ute Ackermann, Dagmar Glatz, Johanna Raithel, Alexander Fischer, Sandra Pohl, Anita Rijneveld, Juan M. Vaquerizas, Christian Thiede, Christoph Plass, Bas J. Wouters, Ruud Delwel, Michael Rehli, Claudia Gebhard
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Leukemias with ambiguous lineage comprise several loosely defined entities, often without a clear mechanistic basis. Here, we extensively profile the epigenome and transcriptome of a subgroup of such leukemias with CpG Island Methylator Phen
Externí odkaz:
https://doaj.org/article/df577d6f414846109f3f3dcf2f2865a4
Autor:
Julia Minderjahn, Alexander Fischer, Konstantin Maier, Karina Mendes, Margit Nuetzel, Johanna Raithel, Hanna Stanewsky, Ute Ackermann, Robert Månsson, Claudia Gebhard, Michael Rehli
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
How chromatin structure and gene accessibility changes during monocyte differentiation is not clearly defined. Here the authors characterize the chromatin changes during macrophage or dendritic cell maturation from monocytes and the dependence of thi
Externí odkaz:
https://doaj.org/article/9b3ed1fbfa844e7484ae6ceb15b31a69
Autor:
Karina Mendes, Sandra Schmidhofer, Julia Minderjahn, Dagmar Glatz, Claudia Kiesewetter, Johanna Raithel, Julia Wimmer, Claudia Gebhard, Michael Rehli
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
DNA methylation turnover is an essential epigenetic process during development. Here, the authors look at the changes in DNA methylation during the differentiation of post-mitotic human monocytes (MO), and find that EGR2 interacts with TET2 and is re
Externí odkaz:
https://doaj.org/article/9f76e08c38bc4cedbd1f8e393116b9f3
Autor:
Julia Minderjahn, Andreas Schmidt, Andreas Fuchs, Rudolf Schill, Johanna Raithel, Magda Babina, Christian Schmidl, Claudia Gebhard, Sandra Schmidhofer, Karina Mendes, Anna Ratermann, Dagmar Glatz, Margit Nützel, Matthias Edinger, Petra Hoffmann, Rainer Spang, Gernot Längst, Axel Imhof, Michael Rehli
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
PU.1 is a master TF of hematopoietic lineage differentiation. Here the authors analyse properties of PU.1 DNA-binding in vitro and genome-wide in vivo across different cell types with native or ectopic PU.1 expression, and uncover the mechanisms gove
Externí odkaz:
https://doaj.org/article/a1e8607ec20a48c6b05e13fafbd8d67e
Autor:
Julia Minderjahn, Andreas Schmidt, Andreas Fuchs, Rudolf Schill, Johanna Raithel, Magda Babina, Christian Schmidl, Claudia Gebhard, Sandra Schmidhofer, Karina Mendes, Anna Ratermann, Dagmar Glatz, Margit Nützel, Matthias Edinger, Petra Hoffmann, Rainer Spang, Gernot Längst, Axel Imhof, Michael Rehli
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/66824d16d96e4929acc4d9b0b4333cea
Autor:
Anna Rosenbaum, Stefan Vordenbäumen, Ralph Brinks, Jutta G Richter, Matthias Schneider, Michael Rehli, Christina Düsing, Alexander Sokolowski, Gamal Chehab, Johanna Raithel, Claudia Gebhard
Publikováno v:
Lupus
Objective Hypomethylation of CD40-ligand (CD40L) in T-cells is associated with increased disease activity in systemic lupus erythematosus (SLE). We therefore investigated possible associations of dietary methyl donors and products with CD40L methylat
Autor:
Anna Rosenbaum, Claudia Gebhard, Stefan Vordenbäumen, Johanna Raithel, Gamal Chehab, Christina Düsing, Alexander Sokolowski, Ralph Brinks, Michael Rehli, Matthias Schneider, Jutta G Richter
Publikováno v:
Lupus. 30:45-51
Objective To comprehensively assess associations of site-specific CD4+-T-cell hypomethylation of the CD40-Ligand gene ( CD40L) with disease activity of women with systemic lupus erythematosus (SLE). Methods CpG-sites within the DNA of the promotor an
Autor:
Petra Hoffmann, Matthias Edinger, Andreas Schmidt, Magda Babina, Sandra Schmidhofer, Gernot Längst, Andreas Fuchs, Michael Rehli, Johanna Raithel, Rudolf Schill, Claudia Gebhard, Dagmar Glatz, Rainer Spang, Margit Nützel, Anna Ratermann, Christian Schmidl, Karina Mendes, Julia Minderjahn, Axel Imhof
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
Establishing gene regulatory networks during differentiation or reprogramming requires master or pioneer transcription factors (TFs) such as PU.1, a prototype master TF of hematopoietic lineage differentiation. To systematically determine molecular f
Autor:
Claudia Gebhard, Julia Minderjahn, Julia Wimmer, Michael Rehli, Sandra Schmidhofer, Dagmar Glatz, Johanna Raithel, Karina Mendes, Claudia Kiesewetter
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Communications
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Communications
The differentiation of human blood monocytes (MO), the post-mitotic precursors of macrophages (MAC) and dendritic cells (moDC), is accompanied by the active turnover of DNA methylation, but the extent, consequences and mechanisms of DNA methylation c
Autor:
Marian Schön, Matthias Lubnow, Christina Bruss, Nathalie Babl, Kristina Kolodova, Jakob Simeth, Jana Klitzke, Christoph Brochhausen, Katrin Singer, Heiko Siegmund, Wolfgang Herr, Hendrik Poeck, Carina Matos, Bernd Salzberger, Alice Peuker, Florian Hitzenbichler, Marina Kreutz, I Ugele, Alexander Dietl, Daniel Wolff, Ralph Burkhardt, Florian Lüke, Florian Geismann, Michael Rehli, Dirk Lunz, Kathrin Renner, Louisa Steines, Daniel Heudobler, Josef Köstler, Johanna Raithel, Rainer Spang, Ralf Wagner, Sonja-Maria Decking, Peter Hau, Peter J. Siska, André Gessner, Katharina Freitag, Michael Paulus, Christopher Bohr, Bernhard M. Graf, Petra Hoffmann, Jonathan Jantsch, Frank Hanses, Gabriele Schönhammer, Matthias Mack, Tobias Pukrop
Publikováno v:
J Clin Invest
Metabolic pathways regulate immune responses and disrupted metabolism leads to immune dysfunction and disease. Coronavirus disease 2019 (COVID-19) is driven by imbalanced immune responses, yet the role of immunometabolism in COVID-19 pathogenesis rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2084baa14ddf905a7838047d2a70bb79