Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Johanna Magga"'
Autor:
Julia Swan, Zoltán Szabó, Juliana Peters, Outi Kummu, Anna Kemppi, Lea Rahtu-Korpela, Anja Konzack, Jukka Hakkola, Arja Pasternack, Olli Ritvos, Risto Kerkelä, Johanna Magga
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116683- (2024)
Objective: Blockade of activin 2 receptor (ACVR2) signaling has been shown to improve insulin sensitivity and aid in weight loss. Inhibition of ACVR2 signaling restores cardiac function in multiple heart failure models. However, its potential in the
Externí odkaz:
https://doaj.org/article/f12e102e8fb44b96a295022015e36e48
Autor:
Ruizhu Lin, Juhani Junttila, Jarkko Piuhola, E. Samuli Lepojärvi, Johanna Magga, Antti M. Kiviniemi, Juha Perkiömäki, Heikki Huikuri, Olavi Ukkola, Mikko Tulppo, Risto Kerkelä
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-9 (2023)
Abstract Background All coronary artery disease (CAD) patients do not benefit equally of secondary prevention. Individualized intensity of drug therapy is currently implemented in guidelines for CAD and diabetes. Novel biomarkers are needed to identi
Externí odkaz:
https://doaj.org/article/3e29b0ab061c45c994f01770949a0d38
Autor:
Manar Elmadani, Sami Raatikainen, Orvokki Mattila, Tarja Alakoski, Jarkko Piuhola, Pirjo Åström, Olli Tenhunen, Johanna Magga, Risto Kerkelä
Publikováno v:
Toxicology Reports, Vol 10, Iss , Pp 521-528 (2023)
Dasatinib is a multitargeted kinase inhibitor used for treatment of chronic myeloid leukemia and acute lymphoblastic leukemia. Unfortunately, treatment of cancer patients with some kinase inhibitors has been associated with cardiotoxicity. Cancer tre
Externí odkaz:
https://doaj.org/article/78ac950203a444f3a338fbcbb7c674d4
Autor:
Ruizhu Lin, Lea Rahtu-Korpela, Johanna Magga, Johanna Ulvila, Julia Swan, Anna Kemppi, Lasse Pakanen, Katja Porvari, Heikki Huikuri, Juhani Junttila, Risto Kerkelä
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 20, Iss , Pp 589-605 (2020)
Non-coding microRNAs (miRNAs) are powerful regulators of gene expression and critically involved in cardiovascular pathophysiology. The aim of the current study was to identify miRNAs regulating cardiac fibrosis. Cardiac samples of age-matched contro
Externí odkaz:
https://doaj.org/article/a2aaa49b59974543a479eb83c8b3b525
Autor:
Laura E. Vainio, MD, Zoltán Szabó, MSc, Ruizhu Lin, MSc, Johanna Ulvila, PhD, Raisa Yrjölä, MSc, Tarja Alakoski, MSc, Jarkko Piuhola, MD, PhD, Walter J. Koch, PhD, Heikki Ruskoaho, MD, PhD, Shaun D. Fouse, PhD, Todd W. Seeley, PhD, Erhe Gao, MD, PhD, Pierre Signore, PhD, Kenneth E. Lipson, PhD, Johanna Magga, PhD, Risto Kerkelä, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 1, Pp 83-94 (2019)
Summary: Myocardial infarction (MI)−induced cardiac fibrosis attenuates cardiac contractile function, and predisposes to arrhythmias and sudden cardiac death. Expression of connective tissue growth factor (CTGF) is elevated in affected organs in vi
Externí odkaz:
https://doaj.org/article/a4c614fa5d9249b080d2fe33ba0c0e4d
Autor:
Jere Paavola, Tarja Alakoski, Johanna Ulvila, Teemu Kilpiö, Juuso Sirén, Sanni Perttunen, Suneeta Narumanchi, Hong Wang, Ruizhu Lin, Katja Porvari, Juhani Junttila, Heikki Huikuri, Katariina Immonen, Päivi Lakkisto, Johanna Magga, Ilkka Tikkanen, Risto Kerkelä
Publikováno v:
EBioMedicine, Vol 51, Iss , Pp - (2020)
Background: Vascular endothelial zinc finger 1 (Vezf1) is a transcription factor previously shown to regulate vasculogenesis and angiogenesis. We aimed to investigate the role of Vezf1 in the postnatal heart. Methods: The role of Vezf1 in regulating
Externí odkaz:
https://doaj.org/article/3c77abab2ac34b3ca0fbf694d31d866e
Autor:
Manar Elmadani, Suleiman Khan, Olli Tenhunen, Johanna Magga, Tero Aittokallio, Krister Wennerberg, Risto Kerkelä
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 21 (2019)
Background Small molecule kinase inhibitors (KIs) are a class of agents currently used for treatment of various cancers. Unfortunately, treatment of cancer patients with some of the KIs is associated with cardiotoxicity, and there is an unmet need fo
Externí odkaz:
https://doaj.org/article/07d2f52188a24363999ca98b66ae2b41
Autor:
Laura Vainio, Saija Taponen, Sini M. Kinnunen, Eveliina Halmetoja, Zoltan Szabo, Tarja Alakoski, Johanna Ulvila, Juhani Junttila, Päivi Lakkisto, Johanna Magga, Risto Kerkelä
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13586 (2021)
Prior studies show that glycogen synthase kinase 3β (GSK3β) contributes to cardiac ischemic injury and cardiac hypertrophy. GSK3β is constitutionally active and phosphorylation of GSK3β at serine 9 (S9) inactivates the kinase and promotes cellula
Externí odkaz:
https://doaj.org/article/8de1a1bbbd7d42f4ab4e54d5aacbe51b
Autor:
Taisia Rolova, Lakshman Puli, Johanna Magga, Hiramani Dhungana, Katja Kanninen, Sara Wojciehowski, Antero Salminen, Heikki Tanila, Jari Koistinaho, Tarja Malm
Publikováno v:
Neurobiology of Disease, Vol 64, Iss , Pp 16-29 (2014)
Inflammation is a major mechanism of acute brain injury and chronic neurodegeneration. This neuroinflammation is known to be substantially regulated by the transcription factor NF-κB, which is predominantly found in the form of heterodimer of p65 (R
Externí odkaz:
https://doaj.org/article/f0b6c68beb8e49dd9a1dedcd9f56ddc1
Autor:
Ekaterina Savchenko, Tarja Malm, Henna Konttinen, Riikka H Hamalainen, Cindy Guerrero-Toro, Sara Wojciechowski, Rashid Giniatullin, Jari Koistinaho, Johanna Magga
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 10 (2016)
Background Accumulation of amyloid β (Aβ) is one of the main hallmarks of Alzheimer’s disease (AD). The enhancement of Aβ clearance may provide therapeutic means to restrict AD pathology. The cellular responses to different forms of Aβ in monoc
Externí odkaz:
https://doaj.org/article/8eb2ab42af6a4bc9a01850460752c4ad