Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Johanna M. Virta"'
Publikováno v:
SLAS Discovery, Vol 29, Iss 5, Pp 100165- (2024)
We report the development of a 384-well formatted NanoBRET assay to characterize molecular glues of 14-3-3/client interactions in living cells. The seven isoforms of 14-3-3 are dimeric hub proteins with diverse roles including transcription factor re
Externí odkaz:
https://doaj.org/article/85badde1d71a4181978e99532b926ef2
Autor:
Dyana N. Kenanova, Emira J. Visser, Johanna M. Virta, Eline Sijbesma, Federica Centorrino, Holly R. Vickery, Mengqi Zhong, R. Jeffrey Neitz, Luc Brunsveld, Christian Ottmann, Michelle R. Arkin
Publikováno v:
ACS Central Science, 9(5), 937-946. American Chemical Society
ACS central science, vol 9, iss 5
ACS central science, vol 9, iss 5
Protein-protein interactions (PPIs) are responsible for the proper function of biological processes and, when dysregulated, commonly lead to disease. PPI stabilization has only recently been systematically explored for drug discovery despite being a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d5dfbb9f85f0ba6a6dbf92e3bacf2b
https://research.tue.nl/nl/publications/076d1025-cb55-4575-b0a2-584f109c7743
https://research.tue.nl/nl/publications/076d1025-cb55-4575-b0a2-584f109c7743
Publikováno v:
Nucleic Acids Research
U6 snRNA undergoes post-transcriptional 3′ end modification prior to incorporation into the active site of spliceosomes. The responsible exoribonuclease is Usb1, which removes nucleotides from the 3′ end of U6 and, in humans, leaves a 2′,3′ c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::601c0f17698d247048eba4240151ee32
https://doi.org/10.1093/nar/gkz1177
https://doi.org/10.1093/nar/gkz1177
Autor:
Johanna M Virta, Samuel E. Butcher, Lauren D. Hagler, Eric J. Montemayor, Steven C. Zimmerman
Publikováno v:
Acta Crystallographica. Section F, Structural Biology Communications
The structure of a 22-base-pair RNA helix with mismatched pyrimidine base pairs is reported. The pyrimidine mismatches are unusual and display sheared, cross-strand stacking geometries that locally constrict the helical width.
The structure of a
The structure of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2847bb55bf60f47cfe93115e9d65a5da
https://doi.org/10.1107/s2053230x19012172
https://doi.org/10.1107/s2053230x19012172
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cf44fde57f5183bca53e3a6243d69bc
https://doi.org/10.1096/fasebj.2019.33.1_supplement.460.12
https://doi.org/10.1096/fasebj.2019.33.1_supplement.460.12