R‐spondin‐mediatedWNTsignaling potentiation in mammary and breast cancer development

Autor: Carla M. Felcher, Martín E García Solá, Johanna M. Tocci, Edith C. Kordon

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

The mammary gland is a secretory organ, which develops as a network of growing epithelial ducts composed of luminal and basal cells that invade the surrounding adipose tissue through a series of developmental cycles. Mammary stem cells (MaSCs) mainta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11cf098c70bf0c6a3f57eaa5c2ab44a
https://doi.org/10.1002/iub.2278

Angiotensin-(1-7) counteracts the transforming effects triggered by angiotensin II in breast cancer cells

Autor: Nadia Cambados, Marina Simian, Rocío Guadalupe Sampayo, Ilka Böhme, Karen Nahmod, Thomas Walther, Melisa Del Valle Suberbordes, Edith C. Kordon, Natalia Rubinstein, Carolina Schere-Levy, Johanna M. Tocci

Publikováno v: Oncotarget

// Nadia Cambados 1 , Thomas Walther 2, 4, 5 , Karen Nahmod 6 , Johanna M. Tocci 1 , Natalia Rubinstein 1, 7 , Ilka Bohme 2, 3 , Marina Simian 8 , Rocio Sampayo 8 , Melisa Del Valle Suberbordes 1 , Edith C. Kordon 1, 9 and Carolina Schere-Levy 1 1 In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76925ed6afc6aa41a4f506b0d815211d
http://europepmc.org/articles/PMC5687620

R-spondin3 Is Associated with Basal-Progenitor Behavior in Normal and Tumor Mammary Cells

Autor: Omar A. Coso, Anabella Srebrow, Roberto Meiss, Johanna M. Tocci, Edith C. Kordon, Martín E García Solá, María Victoria Goddio, Natalia Rubinstein, Carla M. Felcher, María Noel Zimberlin, Martín Carlos Abba

Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

R-spondin3 (RSPO3) is a member of a family of secreted proteins that enhance Wnt signaling pathways in diverse processes, including cancer. However, the role of RSPO3 in mammary gland and breast cancer development remains unclear. In this study, we s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e465e6ac047a82af1a0e5a270a96a7
http://sedici.unlp.edu.ar/handle/10915/124844

Progression of Hormone-Dependent Mammary Tumors After Dormancy: Role of Wnt Pathway

Autor: Nancy E. Hynes, Albana Gattelli, Edith C. Kordon, M. Victoria Goddio, Julian Naipauer, Martín Carlos Abba, Johanna M. Tocci

Publikováno v: Tumor Dormancy, Quiescence, and Senescence, Vol. 3 ISBN: 9789401793247

The cancer stem cell theory suggests the existence of cells within breast cancers that possess the ability to self-renew and differentiate, albeit in a deregulated manner, which sustains tumor progression. Therefore, latent breast tumors and/or their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c7088e909fa1929d340d6c51bec03e4
https://doi.org/10.1007/978-94-017-9325-4_6

Progesterone Receptor Induces ErbB-2 Nuclear Translocation To Promote Breast Cancer Growth via a Novel Transcriptional Effect: ErbB-2 Function as a Coactivator of Stat3

Autor: María Celeste Díaz Flaqué, Martín A. Rivas, Cecilia J. Proietti, Mercedes Tkach, Cinthia Rosemblit, Eduardo H. Charreau, Wendy Béguelin, Roxana Schillaci, Johanna M. Tocci, Patricia V. Elizalde, Florencia Cayrol

Progesterone receptor (PR) and ErbB-2 bidirectional cross talk participates in breast cancer development. Here, we identified a new mechanism of the PR and ErbB-2 interaction involving the PR induction of ErbB-2 nuclear translocation and the assembly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03117b3a2ef34619c50f24cdf372d3d6
http://mcb.asm.org/content/30/23/5456.long