Výsledky vyhledávání - "Johanna M. Smeekens"

Akademický článek

Food‐specific IgA levels in esophageal biopsies are not sufficiently high to predict food triggers in eosinophilic esophagitis

Autor: Lior Abramson, Johanna M. Smeekens, Michael D. Kulis, Evan S. Dellon

Publikováno v: Immunity, Inflammation and Disease, Vol 11, Iss 9, Pp n/a-n/a (2023)

Abstract Background Eosinophilic esophagitis (EoE) is an immune‐mediated disease, characterized by Th2‐type inflammation linked to specific foods. No currently available allergy tests reliably identify food triggers in EoE, leading to empiric die

Externí odkaz: https://doaj.org/article/2d16720d916d42ababdc7b2d914b0ae8

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Akademický článek

Peanut butter feeding induces oral tolerance in genetically diverse collaborative cross mice

Autor: Robert M. Immormino, Johanna M. Smeekens, Priscilla I. Mathai, Janelle R. Kesselring, Andrew V. Turner, Michael D. Kulis, Timothy P. Moran

Publikováno v: Frontiers in Allergy, Vol 4 (2023)

BackgroundEarly dietary introduction of peanut has shown efficacy in clinical trials and driven pediatric recommendations for early introduction of peanut to children with heightened allergy risk worldwide. Unfortunately, tolerance is not induced in

Externí odkaz: https://doaj.org/article/592b64addfd6418d96db6ce758376f7e

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Akademický článek

Induction of food-specific IgG by Gene Gun-delivered DNA vaccines

Autor: Johanna M. Smeekens, Janelle R. Kesselring, Hannah Frizzell, Kenneth C. Bagley, Michael D. Kulis

Publikováno v: Frontiers in Allergy, Vol 3 (2022)

BackgroundShellfish and tree nut allergies are among the most prevalent food allergies, now affecting 2%–3% and 1% of the US population, respectively. Currently, there are no approved therapies for shellfish or tree nut allergies, with strict avoid

Externí odkaz: https://doaj.org/article/3ec5b4af380042c5abd22838ae66904d

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Akademický článek

Peanut applied to the skin of nonhuman primates induces antigen‐specific IgG but not IgE

Autor: Michael D. Kulis, Johanna M. Smeekens, Kylie Kavanagh, Matthew J. Jorgensen

Publikováno v: Immunity, Inflammation and Disease, Vol 8, Iss 2, Pp 211-215 (2020)

Abstract Introduction Previous studies in humans support the dual‐allergen exposure hypothesis, and several studies in mouse models have demonstrated that cutaneous exposure to disrupted or intact skin can lead to sensitization to peanut. However,

Externí odkaz: https://doaj.org/article/eb775adec6904ec1857669380e175745

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Akademický článek

Mouse Models of Food Allergy in the Pursuit of Novel Treatment Modalities

Autor: Johanna M. Smeekens, Michael D. Kulis

Publikováno v: Frontiers in Allergy, Vol 2 (2021)

The prevalence of IgE-mediated food allergies has increased dramatically in the past three decades, now affecting up to 10% of the US population. IgE-mediated food allergy is an immunologic disease, involving a variety of cells, including B and T cel

Externí odkaz: https://doaj.org/article/14f7fe219d3e4ad1bad4aa76474ab1e3

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Akademický článek

Fecal IgA, Antigen Absorption, and Gut Microbiome Composition Are Associated With Food Antigen Sensitization in Genetically Susceptible Mice

Autor: Johanna M. Smeekens, Brandi T. Johnson-Weaver, Andrew L. Hinton, M. Andrea Azcarate-Peril, Timothy P. Moran, Robert M. Immormino, Janelle R. Kesselring, Erin C. Steinbach, Kelly A. Orgel, Herman F. Staats, A. Wesley Burks, Peter J. Mucha, Martin T. Ferris, Michael D. Kulis

Publikováno v: Frontiers in Immunology, Vol 11 (2021)

Food allergy is a potentially fatal disease affecting 8% of children and has become increasingly common in the past two decades. Despite the prevalence and severe nature of the disease, the mechanisms underlying sensitization remain to be further elu

Externí odkaz: https://doaj.org/article/841f66418b1d4c8393bc5558dcc2038b

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Akademický článek

An enrichment method based on synergistic and reversible covalent interactions for large-scale analysis of glycoproteins

Autor: Haopeng Xiao, Weixuan Chen, Johanna M. Smeekens, Ronghu Wu

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

Understanding the functions of protein glycosylation critically depends on methods to efficiently enrich glycoproteins from complex samples. Here, the authors develop a strategy using dendrimer-conjugated benzoboroxole to enhance glycopeptide enrichm

Externí odkaz: https://doaj.org/article/003e950ab8cd4085b921ab58ee0f6809

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