Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Johanna M. Beekman"'
Publikováno v:
Experimental and Toxicologic Pathology. 65:949-960
Introduction Investigation of molecular mechanisms by gene expression profiling gains increasingly importance in preclinical safety evaluation. However, assigning expressed genes to specific cell populations is nearly impossible if the investigated R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a58e67d76b6baf3c7a9b8eb369e793db
https://doi.org/10.1016/j.etp.2013.01.009
https://doi.org/10.1016/j.etp.2013.01.009
Autor:
Christiane Otto, Carsten Möller, Ulrike Dr. Fuhrmann, Jens Hoffmann, Johanna M. Beekman, Daniel Korr, Wiebke Afhüppe
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 119:45-55
The progesterone receptor (PR) is a key regulator of female reproductive functions. Compounds with progesterone inhibiting effects (PR antagonists) have found numerous utilities in female reproductive health, ranging from contraception to potential t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a6616e2a62f22b80f6ade3300a6d50c
https://doi.org/10.1016/j.jsbmb.2009.12.011
https://doi.org/10.1016/j.jsbmb.2009.12.011
Autor:
Susanne Schwenke, Johannes Lampe, Rupert Sandbrink, Joachim Reischl, Jan Hilpert, Kristin Kowal, Jürgen F. Heubach, Johanna M. Beekman, Steffen Stürzebecher, David Bauer
Publikováno v:
Journal of Neuroimmunology. 199:115-125
Treatment with interferon β-1b (IFNB-1b) is clinically effective in multiple sclerosis patients. However, the mechanism of action is only partially understood, and validated biological response markers are lacking. We assessed IFNB-1b-induced transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226206a76314aba59c99ba6f8d7eab6a
https://doi.org/10.1016/j.jneuroim.2008.04.036
https://doi.org/10.1016/j.jneuroim.2008.04.036
Autor:
Johanna M. Beekman, Joachim Reischl, Susanne Schwenke, Jürgen F. Heubach, Ulrich Mrowietz, Stürzebecher S
Publikováno v:
Journal of Investigative Dermatology. 127(1):163-169
Psoriasis vulgaris is characterized by hyperproliferation and incomplete terminal differentiation of epidermal keratinocytes. Despite the established role of Wnt pathways in the regulation of stem cell proliferation and differentiation, they have not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59370f15532e0dd6575847b31803889
Publikováno v:
Environmental Health Perspectives
Genomics technologies are used in several disciplines, including toxicology. However, these technologies are relatively new, and their applications require further investigations. When investigators apply these technologies to in vitro experiments, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55631633ae5770deca69a6b178997a72
https://doi.org/10.1289/ehp.7915
https://doi.org/10.1289/ehp.7915
Autor:
Nancy H. Ing, Michael E. Hogan, Krishna Jayaraman, Johanna M. Beekman, Donald J. Kessler, Ming-Jer Tsai, Joseph G. Zendegui, Bert W. O'Malley, Mark W. Murphy
Publikováno v:
Nucleic Acids Research. 21:2789-2796
Oligonucleotides provide novel reagents for inhibition of gene expression because of their high affinity binding to specific nucleotide sequences. We describe a 38 base, single-stranded DNA that forms a triple helix or 'triplex' on progesterone respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e96b3ae8bde9fc716b5bb86ee758ccd
https://doi.org/10.1093/nar/21.12.2789
https://doi.org/10.1093/nar/21.12.2789
Publikováno v:
Toxicogenomics: A Powerful Tool for Toxicity Assessment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5107aa2a1d10addd93890135b4586a6
https://doi.org/10.1002/9780470699638.ch1
https://doi.org/10.1002/9780470699638.ch1
Autor:
Jürgen F. Heubach, Chetan Lathia, David Bauer, David Henderson, Rainer Ternes, Johanna M. Beekman, Carol Peña, Joachim Reischl
Publikováno v:
Journal of pharmacological and toxicological methods. 59(1)
Introduction The availability of blood collection systems with RNA stabilizing additives (e.g. PAXgene) has opened the field for gene expression profiling in large multi-center clinical trials. Here, we investigated whether the PAXgene system also of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c065d90eb26a4c987c24b4852e73578
https://pubmed.ncbi.nlm.nih.gov/19028589
https://pubmed.ncbi.nlm.nih.gov/19028589
Autor:
J. Peter, Fred van Leeuwen, Roger A.H. Adan, Johanna M. Beekman, Geert Ab, Hubert H.M. Van Tol, Marleen A.E. Verbeeck, H. Burbach, John F. Axelson
Publikováno v:
Journal of Neuroendocrinology. 2:633-639
Oxytocin (OT) plays a role in reproduction at the level of the pituitary and mammary glands and uterus. This OT is synthesized in the hypothalamo-neurohypophyseal system (HNS). A number of observations have suggested that estrogens regulate the produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a582fbe6a0a31c73c5a121f59213e88c
https://doi.org/10.1111/j.1365-2826.1990.tb00458.x
https://doi.org/10.1111/j.1365-2826.1990.tb00458.x
Autor:
Laura Suter, Johanna M. Beekman, Nick Flint, Frank Staedtler, Arno Kalkuhl, Michael T. Lawton, Jeffrey F. Waring, David Morfitt, Roger G. Ulrich
Publikováno v:
Environmental health perspectives, vol 112, iss 4
Environmental Health Perspectives
Environmental Health Perspectives
Several studies using microarrays have shown that changes in gene expression provide information about the mechanism of toxicity induced by xenobiotic agents. Nevertheless, the issue of whether gene expression profiles are reproducible across differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afebf103ec36006bf990a035051d31e
https://escholarship.org/uc/item/5hp0f3k7
https://escholarship.org/uc/item/5hp0f3k7