Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Johanna L. Crimins"'
Publikováno v:
Estrogens and Memory
A compelling case can be made for estrogen’s role in maintaining synaptic health in the context of cognitive aging. This chapter first reviews clinical literature pertinent to estrogenic actions on cognition in menopausal women. Next, the authors p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3eee0347d4a29343aa588c40a56cef3
https://doi.org/10.1093/oso/9780190645908.003.0018
https://doi.org/10.1093/oso/9780190645908.003.0018
Autor:
Min Wang, Amy F.T. Arnsten, Constantinos D. Paspalas, Johanna L. Crimins, James A. Mazer, Marcus T. Altman, Sheng-Tao Yang
Publikováno v:
Cerebral Cortex (New York, NY)
Neurons in primary visual cortex (V1) are more resilient than those in dorsolateral prefrontal cortex (dlPFC) in aging, schizophrenia and Alzheimer’s disease. The current study compared glutamate and neuromodulatory actions in macaque V1 to those i
Autor:
Douglas L. Rosene, Christopher H. van Dyck, Amy F.T. Arnsten, Anita Huttner, Angus C. Nairn, Johanna L. Crimins, Shannon N. Leslie, Constantinos D. Paspalas, Becky C. Carlyle, Todd M. Preuss
Publikováno v:
Alzheimer's & dementia : the journal of the Alzheimer's Association
Introduction An animal model of late-onset Alzheimer's disease is needed to research what causes degeneration in the absence of dominant genetic insults and why the association cortex is particularly vulnerable to degeneration. Methods We studied the
Autor:
Johanna L. Crimins, Mark G. Baxter
Publikováno v:
Neuron. 98:1064-1066
Drug treatments to improve memory focus on enhancing acetylcholine. However, Vijayraghavan and colleagues (2018) show that direct stimulation of the M1 muscarinic acetylcholine receptor adversely affected neuronal activity in prefrontal cortex relate
Autor:
Yuko Hara, Peter R. Rapp, Athena Ching-Jung Wang, Rishi Puri, William G.M. Janssen, Sarah E. Motley, Johanna L. Crimins, Tiffany M. Ramos, John H. Morrison, Frank J. Yuk
Age- and menopause-related deficits in working memory can be partially restored with estradiol replacement in women and female nonhuman primates. Working memory is a cognitive function reliant on persistent firing of dorsolateral prefrontal cortex (d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d03a004571ee57cf415753e88a8c81
https://europepmc.org/articles/PMC6394848/
https://europepmc.org/articles/PMC6394848/
Autor:
Yuko Hara, Frank J. Yuk, Rishi Puri, Katina C. Calakos, John H. Morrison, Johanna L. Crimins, Peter R. Rapp, William G.M. Janssen
Publikováno v:
The Journal of comparative neurology. 527(4)
Female rhesus monkeys and women are subject to age- and menopause-related deficits in working memory, an executive function mediated by the dorsolateral prefrontal cortex (dlPFC). Long-term cyclic administration of 17β-estradiol improves working mem
Autor:
Shannon N. Leslie, Johanna L. Crimins, Douglas L. Rosene, Constantinos D. Paspalas, Dibyadeep Datta, Todd M. Preuss, Amy F.T. Arnsten, Becky C. Carlyle, Huttner J. Anita, Christopher H. van Dyck, Angus C. Nairn
Publikováno v:
Alzheimer's & Dementia. 14
Autor:
Patrick R. Hof, Maria Medalla, Joseph M. Amatrudo, Christina M. Weaver, Jennifer I. Luebke, Alan Peters, Brendan Hunt, Johanna L. Crimins
Publikováno v:
Cerebral Cortex. 25:1454-1468
The effects of normal aging on morphologic and electrophysiologic properties of layer 3 pyramidal neurons in rhesus monkey primary visual cortex (V1) were assessed with whole-cell, patch-clamp recordings in in vitro slices. In another cohort of monke
Autor:
Jennifer I. Luebke, Johanna L. Crimins, Manuela Polydoro, Amy M. Pooler, Tara L. Spires-Jones
Publikováno v:
Ageing Research Reviews. 12:757-763
The synaptic connections that form between neurons during development remain plastic and able to adapt throughout the lifespan, enabling learning and memory. However, during aging and in particular in neurodegenerative diseases, synapses become dysfu
Autor:
Patrick R. Hof, Jennifer I. Luebke, Joseph M. Amatrudo, Johanna L. Crimins, Douglas L. Rosene, Christina M. Weaver
Publikováno v:
The Journal of Neuroscience. 32:13644-13660
Whole-cell patch-clamp recordings and high-resolution 3D morphometric analyses of layer 3 pyramidal neurons inin vitroslices of monkey primary visual cortex (V1) and dorsolateral granular prefrontal cortex (dlPFC) revealed that neurons in these two b