Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Johanna Knöferle"'
Autor:
Lucas Caldi Gomes, Sonja Hänzelmann, Fabian Hausmann, Robin Khatri, Sergio Oller, Mojan Parvaz, Laura Tzeplaeff, Laura Pasetto, Marie Gebelin, Melanie Ebbing, Constantin Holzapfel, Stefano Fabrizio Columbro, Serena Scozzari, Johanna Knöferle, Isabell Cordts, Antonia F. Demleitner, Marcus Deschauer, Claudia Dufke, Marc Sturm, Qihui Zhou, Pavol Zelina, Emma Sudria-Lopez, Tobias B. Haack, Sebastian Streb, Magdalena Kuzma-Kozakiewicz, Dieter Edbauer, R. Jeroen Pasterkamp, Endre Laczko, Hubert Rehrauer, Ralph Schlapbach, Christine Carapito, Valentina Bonetto, Stefan Bonn, Paul Lingor
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Amyotrophic lateral sclerosis (ALS) is a debilitating motor neuron disease and lacks effective disease-modifying treatments. This study utilizes a comprehensive multiomic approach to investigate the early and sex-specific molecular mechanism
Externí odkaz:
https://doaj.org/article/a01f4f133f534a40923cc24277e82506
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59478 (2013)
Apolipoprotein (apo) E4 is the leading genetic risk factor for Alzheimer's disease (AD), and it has a gene dose-dependent effect on the risk and age of onset of AD. Although apoE4 is primarily produced by astrocytes in the brain, neurons can also pro
Externí odkaz:
https://doaj.org/article/5f0cfc751797450ea86e16a5964542aa
Autor:
Johanna Knöferle, Sanja Ramljak, Jan C. Koch, Lars Tönges, Abdul R. Asif, Uwe Michel, Fred S. Wouters, Stephan Heermann, Kerstin Krieglstein, Inga Zerr, Mathias Bähr, Paul Lingor
Publikováno v:
Neurobiology of Disease, Vol 38, Iss 3, Pp 395-404 (2010)
Malfunction of the ubiquitin–proteasome system has been implicated as a causal factor in the pathogenesis of aggregation-related disorders, e.g. Parkinson's disease. We show here that Transforming growth factor-beta 1 (TGF-β), a multifunctional cy
Externí odkaz:
https://doaj.org/article/e203a224898445e183fa8f8de9d825eb
Autor:
Peter Androvic, Martina Schifferer, Katrin Perez Anderson, Ludovico Cantuti-Castelvetri, Hanyi Jiang, Hao Ji, Lu Liu, Garyfallia Gouna, Stefan A. Berghoff, Simon Besson-Girard, Johanna Knoferle, Mikael Simons, Ozgun Gokce
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Understanding the complexity of cellular function within a tissue necessitates the combination of multiple phenotypic readouts. Here, we developed a method that links spatially-resolved gene expression of single cells with their ultrastructu
Externí odkaz:
https://doaj.org/article/c66140bd92484a63acc14ed3e67b9854
Publikováno v:
Nature Protocols. 6:1887-1896
In this protocol, we describe the imaging of single axons in the rat optic nerve in vivo. Axons are labeled through the intravitreal injection of adeno-associated viral vectors (AAVs) expressing a fluorophore (duration of the procedure ∼1 h). Two w
Autor:
Sanja Ramljak, Jan C. Koch, Lars Tönges, Paul Lingor, Uwe Michel, Kerstin Krieglstein, Johanna Knöferle, Inga Zerr, Stephan Heermann, Fred S. Wouters, Mathias Bähr, Abdul R. Asif
Publikováno v:
Neurobiology of Disease, Vol 38, Iss 3, Pp 395-404 (2010)
Malfunction of the ubiquitin-proteasome system has been implicated as a causal factor in the pathogenesis of aggregation-related disorders, e.g. Parkinson's disease. We show here that Transforming growth factor-beta 1 (TGF-beta), a multifunctional cy
Publikováno v:
Autophagy. 6(5)
Axonal degeneration is a pathological hallmark of many traumatic and neurodegenerative neurological disorders. Although the underlying mechanisms remain largely unclear, increased autophagy and the influx of extracellular calcium have been implicated
Autor:
Jan C. Koch, Mathias Bähr, Veronique Planchamp, Lars Tönges, Johanna Knöferle, Wolfgang Brück, Christine Stadelmann, Paul Lingor, Thomas Ostendorf, Uwe Michel, Polya Vutova
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 107(13)
Axonal degeneration is an initial key step in traumatic and neurodegenerative CNS disorders. We established a unique in vivo epifluorescence imaging paradigm to characterize very early events in axonal degeneration in the rat optic nerve. Single reti
Autor:
Thomas Michaelis, Sonja Hochmeister, Johanna Knöferle, Susann Boretius, Ivana Gadjanski, Ricarda Diem, Jens Frahm, Kurt-Wolfram Sühs, Richard Fairless, Paul Lingor, Muriel B. Sättler, Sarah K. Williams, Mathias Bähr, Maria K. Storch
Publikováno v:
Annals of Neurology
Objective: The aim of this study was to investigate the role of voltage-dependent calcium channels (VDCCs) in axon degeneration during autoimmune optic neuritis. Methods: Calcium ion (Ca 2 ) influx into the optic nerve (ON) through VDCCs was investig
Autor:
Tomas Racek, Carsten Scheller, Anett Ullrich, Eleni Koutsilieri, Johannes Prottengeier, Johanna Knöferle, Sieghart Sopper, Christian Jassoy, Axel Rethwilm
Publikováno v:
Journal of cellular biochemistry. 97(6)
CD95 (Fas/Apo-1) triggers apoptotic cell death via a caspase-dependent pathway. Inhibition of caspase activation blocks proapoptotic signaling and thus, prevents execution of apoptosis. Besides induction of apoptotic cell death, CD95 has been reporte