Proteome-scale characterisation of motif-based interactome rewiring by disease mutations

Autor: Johanna Kliche, Leandro Simonetti, Izabella Krystkowiak, Hanna Kuss, Marcel Diallo, Emma Rask, Jakob Nilsson, Norman E Davey, Ylva Ivarsson

Publikováno v: Molecular Systems Biology, Vol 20, Iss 9, Pp 1025-1048 (2024)

Abstract Whole genome and exome sequencing are reporting on hundreds of thousands of missense mutations. Taking a pan-disease approach, we explored how mutations in intrinsically disordered regions (IDRs) break or generate protein interactions mediat

Externí odkaz: https://doaj.org/article/0bbc2585d8e5430193b425c67f6f3b23

Proteome‐scale mapping of binding sites in the unstructured regions of the human proteome

Autor: Caroline Benz, Muhammad Ali, Izabella Krystkowiak, Leandro Simonetti, Ahmed Sayadi, Filip Mihalic, Johanna Kliche, Eva Andersson, Per Jemth, Norman E Davey, Ylva Ivarsson

Publikováno v: Molecular Systems Biology, Vol 18, Iss 1, Pp 1-27 (2022)

Abstract Specific protein–protein interactions are central to all processes that underlie cell physiology. Numerous studies have together identified hundreds of thousands of human protein–protein interactions. However, many interactions remain to

Externí odkaz: https://doaj.org/article/f6abadd527bf44d9a60e048c7d8b617c

Orchestrating serine/threonine phosphorylation and elucidating downstream effects by short linear motifs

Autor: Johanna Kliche, Ylva Ivarsson

Publikováno v: Biochemical Journal

Cellular function is based on protein–protein interactions. A large proportion of these interactions involves the binding of short linear motifs (SLiMs) by folded globular domains. These interactions are regulated by post-translational modification

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e229639bd0886f333df83ce1a8d4d1
https://doi.org/10.1042/bcj20200714

Large-scale identification of phospho-modulated motif-based protein-protein interactions

Autor: Johanna Kliche, Dimitriya Hristoforova Garvanska, Leandro Simonetti, Dilip Badgujar, Doreen Dobritzsch, Jakob Nilsson, Norman Davey, Ylva Ivarsson

Phosphorylation is an extensively studied post-translation modification that regulates protein function by promoting, inhibiting or modulating protein-protein interactions. Deciphering which of the hundreds of thousands of phosphosites in the proteom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5fa40731398fa2d3e31915e10433d597
https://doi.org/10.1101/2022.06.08.495335

Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities

Autor: Leandro Simonetti, Fabian Coscia, Matthias Mann, Andreas Mund, Ylva Ivarsson, Ahmed Sayadi, Raviteja Inturi, Ainhoa Moliner Morro, Muhammad Akhtar Ali, Eva Andersson, Caroline Benz, Emma Nilsson, Filip Mihalic, Thomas Kruse, Johanna Kliche, Anna K. Överby, Jakob Nilsson, Gerald M. McInerney, Richard Lindqvist, Dimitriya H Garvanska, Norman E. Davey, Per Jemth

Publikováno v: bioRxiv
Kruse, T, Benz, C, Garvanska, D H, Lindqvist, R, Mihalic, F, Coscia, F, Inturi, R, Sayadi, A, Simonetti, L, Nilsson, E, Ali, M, Kliche, J, Moliner Morro, A, Mund, A, Andersson, E, McInerney, G, Mann, M, Jemth, P, Davey, N E, Överby, A K, Nilsson, J & Ivarsson, Y 2021, ' Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities ', Nature Communications, vol. 12, no. 1, 6761 . https://doi.org/10.1038/s41467-021-26498-z
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Viral proteins make extensive use of short peptide interaction motifs to hijack cellular host factors. However, most current large-scale methods do not identify this important class of protein-protein interactions. Uncovering peptide mediated interac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15dfa469f4d1901888b1c305c45a2fae