Výsledky vyhledávání - "Johanna Kaufmann"

Akademický článek

A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)

A G protein-coupled receptors (GPCRs) phosphorylation assay for cell culture plates can be used for ligand profiling and inhibitor screening, as evidenced by the identification of two GRK inhibitor compounds.

Externí odkaz: https://doaj.org/article/6d354c7b140b4e0489510cad7b49570b

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Akademický článek

Altered fractionation short-course radiotherapy for stage II-III rectal cancer: a retrospective study

Autor: Hans Geinitz, Carsten Nieder, Lukas Kocik, Christine Track, Johann Feichtinger, Theresa Weingartner, Kurt Spiegl, Barbara Füreder-Kitzmüller, Johanna Kaufmann, Dietmar H. Seewald, Reinhold Függer, Andreas Shamiyeh, Andreas L. Petzer, David Kiesl, Josef Hammer

Publikováno v: Radiation Oncology, Vol 15, Iss 1, Pp 1-9 (2020)

Abstract Purpose To report the long-term outcomes of neoadjuvant altered fractionation short-course radiotherapy in 271 consecutive patients with stage II-III rectal cancer. Patients and Methods: This was a retrospective single institution study with

Externí odkaz: https://doaj.org/article/82faf28c0ab24d36943d95310f80ca2f

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747 CodaLytic™, a novel codon-pair deoptimized influenza virus creates an immune-stimulatory tumor microenvironment leading to monotherapy efficacy in a preclinical model of breast cancer

Autor: Juliana Tafrova, Steffen Mueller, Sybil A. Tasker, J. Robert Coleman, Marcin Stawowczyk, Katie Pfeffer, Charles B. Stauft, Johanna Kaufmann, Anna Kushnir

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

BackgroundOncolytic viruses (OVs) of multiple species have been demonstrated to induce beneficial changes in the tumor microenvironment (TME), increasing immune cell infiltration and activating stimulatory immune responses, which ultimately support i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba562964dad1b78b6cee1c8783ff8258
https://doaj.org/article/48c486fc5a694640a8100f05390d164c

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Response to anti-PD-1 and anti-LAG-3 immune checkpoint blockade is associated with induction of pro-inflammatory Tregs

Autor: Annah S Rolig, Elizabeth R Sturgill, Courtney Mick, Daniel Rose, Johanna Kaufmann, Niranjan Yanamandra, Sue Griffin, James Smothers, William L Redmond

Publikováno v: The Journal of Immunology. 208:119.12-119.12

Only a subset of patients durable clinical responses to aPD-1 and/or aCTLA-4 immunotherapies, thus, developing new therapeutic agents to increase the proportion of responding patients is a priority. Combining aPD-1 with aLAG-3 has shown promising res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bcee3e6347319384a9a4bcee7da3cbfc
https://doi.org/10.4049/jimmunol.208.supp.119.12

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Altered fractionation short-course radiotherapy for stage II-III rectal cancer: A retrospective study

Autor: Lukas Kocik, C. Track, David Kiesl, Kurt Spiegl, Hans Geinitz, D.H. Seewald, Barbara Füreder-Kitzmüller, Johanna Kaufmann, Andreas L. Petzer, Theresa Weingartner, J. Hammer, Johann Feichtinger, Carsten Nieder, Reinhold Függer, Andreas Shamiyeh

Publikováno v: Radiation Oncology, Vol 15, Iss 1, Pp 1-9 (2020)
Radiation Oncology (London, England)

Purpose: To report the long-term outcomes of neoadjuvant altered fractionation short-course radiotherapy in 271 consecutive patients with stage II-III rectal cancer. Patients and Methods: This was a retrospective single institution study with median

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7eaa66e4328793f9397053b7623fc1
https://hdl.handle.net/10037/18944

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The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake

Autor: Olabisi Osunmakinde, Daiana Pamela Celias, Kay Hänggi, Alexis Onimus, Eslam Mohamed, Bruna Batista-Bittencourt, Xiaoqing Yu, Alycia Gardner, Álvaro de Mingo Pulido, Vincent C. Luca, Hatem Soliman, Tsuneyasu Kaisho, Kristen McEachern, Jie Li, Reymi Peña, Jimena Trillo-Tinoco, Brian Ruffell, Paulo C. Rodriguez, Johanna Kaufmann

Publikováno v: de Mingo Pulido, Á, Hänggi, K, Celias, D P, Gardner, A, Li, J, Batista-Bittencourt, B, Mohamed, E, Trillo-Tinoco, J, Osunmakinde, O, Peña, R, Onimus, A, Kaisho, T, Kaufmann, J, McEachern, K, Soliman, H, Luca, V C, Rodriguez, P C, Yu, X & Ruffell, B 2021, ' The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake ', Immunity, vol. 54, no. 6, pp. 1154-1167 . https://doi.org/10.1016/j.immuni.2021.04.019
Immunity

Blockade of the inhibitory receptor TIM-3 shows efficacy in cancer immunotherapy clinical trials. TIM-3 inhibits production of the chemokine CXCL9 by XCR1+ classical dendritic cells (cDC1), thereby limiting antitumor immunity in mammary carcinomas. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b059daa04afcb695b635ed0bf185936
https://doi.org/10.1016/j.immuni.2021.04.019

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Configurations of User Involvement and Participation in Relation to Information System Project Success

Autor: Michael Burgmaier, Marco Baumer, Johanna Kaufmann, Benjamin Mueller, Alexander Maedche, Phillip Haake, Kay Eichhorn

Publikováno v: Advanced Information Systems Engineering ISBN: 9783319915623
CAiSE

Information system (IS) project success is crucial given the importance of these projects for many organizations. We examine the role of user involvement and participation (UIP) for IS project success in terms of perceived usability in 16 cases, wher

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56a98cd3a7718b700f7e6b4db2062d3a
https://doi.org/10.1007/978-3-319-91563-0_6

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