Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Johanna K. Ahlskog"'
Autor:
Aurélie de Thonel, Johanna K. Ahlskog, Kevin Daupin, Véronique Dubreuil, Jérémy Berthelet, Carole Chaput, Geoffrey Pires, Camille Leonetti, Ryma Abane, Lluís Cordón Barris, Isabelle Leray, Anna L. Aalto, Sarah Naceri, Marine Cordonnier, Carène Benasolo, Matthieu Sanial, Agathe Duchateau, Anniina Vihervaara, Mikael C. Puustinen, Federico Miozzo, Patricia Fergelot, Élise Lebigot, Alain Verloes, Pierre Gressens, Didier Lacombe, Jessica Gobbo, Carmen Garrido, Sandy D. Westerheide, Laurent David, Michel Petitjean, Olivier Taboureau, Fernando Rodrigues-Lima, Sandrine Passemard, Délara Sabéran-Djoneidi, Laurent Nguyen, Madeline Lancaster, Lea Sistonen, Valérie Mezger
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Abstract Patients carrying autosomal dominant mutations in the histone/lysine acetyl transferases CBP or EP300 develop a neurodevelopmental disorder: Rubinstein-Taybi syndrome (RSTS). The biological pathways underlying these neurodevelopmental defect
Externí odkaz:
https://doaj.org/article/9f7e7aecc3a8463b9a5732585bfbb110
Autor:
Aurélie de Thonel, Johanna K. Ahlskog, Kevin Daupin, Véronique Dubreuil, Jérémy Berthelet, Carole Chaput, Geoffrey Pires, Camille Leonetti, Ryma Abane, Lluís Cordón Barris, Isabelle Leray, Anna L. Aalto, Sarah Naceri, Marine Cordonnier, Carène Benasolo, Matthieu Sanial, Agathe Duchateau, Anniina Vihervaara, Mikael C. Puustinen, Federico Miozzo, Patricia Fergelot, Élise Lebigot, Alain Verloes, Pierre Gressens, Didier Lacombe, Jessica Gobbo, Carmen Garrido, Sandy D. Westerheide, Laurent David, Michel Petitjean, Olivier Taboureau, Fernando Rodrigues-Lima, Sandrine Passemard, Délara Sabéran-Djoneidi, Laurent Nguyen, Madeline Lancaster, Lea Sistonen, Valérie Mezger
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/4589c26879ce46d1a03bf9df8d0e1d72
Autor:
Johanna K. Ahlskog, Antti Pohjakallio, Ralf Paul, Martin Augustin, Elisabeth Schneider, Sakshi Johri, Tuomas Tervahauta, Hans-Georg Beisel, Lars Neumann, Julia Lindqvist, Anu Moilanen
Publikováno v:
Cancer Research. 83:6179-6179
Background: DNA Polymerase θ (Polθ) is active in Theta-mediated end joining (TMEJ), a repair pathway that utilizes resected 3’ ends and micro-homology sequences to repair double strand breaks. Polθ contains an N-terminal helicase domain and a C-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a398847ea3513ad142d5cc706bdaf5e
https://doi.org/10.1158/1538-7445.am2023-6179
https://doi.org/10.1158/1538-7445.am2023-6179
Autor:
Brian D. Larsen, Jan Benada, Philip Yuk Kwong Yung, Ryan A. V. Bell, George Pappas, Vaclav Urban, Johanna K. Ahlskog, Tia T. Kuo, Pavel Janscak, Lynn A. Megeney, Simon J. Elsässer, Jiri Bartek, Claus S. Sørensen
Genotoxic therapy such as radiation serves as a frontline cancer treatment, yet acquired resistance that leads to tumor reoccurrence is frequent. We found that cancer cells maintain viability during irradiation by reversibly increasing genome-wide DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f94a98c77fd839512eb03c92cbac49d7
Autor:
Carène Benasolo, Élise Lebigot, Jérémy Berthelet, Madeline A. Lancaster, Federico Miozzo, Didier Lacombe, Sarah Naceri, Déborah Bouvier, Olivier Taboureau, Aurélie de Thonel, Johanna K. Ahlskog, Véronique Dubreuil, Mathilde Henry, Pierre Gressens, Sandrine Passemart, Matthieu Sanial, Jean-Paul Concordet, Délara Sabéran-Djoneidi, Patricia Fergelot, Marion Cordonnier, Jessica Gobbo, Mikael C. Puustinen, Anna L. Aalto, Agathe Duchateau, Michel Petitjean, Ryma Abane, Alain Verloes, Lea Sistonen, Carmen Garrido, Valérie Mezger, Sandy D. Westerheide, Anniina Vihervaara, Fernando Rodrigues-Uma, Geoffrey Pires
SUMMARYCells respond to protein-damaging insults by activating heat shock factors (HSFs), key transcription factors of proteostasis. Abnormal HSF protein levels occur in cancer and neurodegenerative disorders, highlighting the importance of the tight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7632caa55526350c6374166293dbf678
Autor:
Yanying Huo, Johanna K. Ahlskog, Gabriele Vincelli, Claus Storgaard Sørensen, Tzeh Keong Foo, Shridar Ganesan, Srilatha Simhadri, Sarah M. Misenko, Samuel F. Bunting, Bing Xia, Gregory G. Oakley
Publikováno v:
Oncogene
The G2/M checkpoint inhibits mitotic entry upon DNA damage, thereby preventing segregation of broken chromosomes and preserving genome stability. The tumor suppressor proteins BRCA1, PALB2 and BRCA2 constitute a BRCA1-PALB2-BRCA2 axis that is essenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c1663a852a0424857ba6c5db32b148
https://pubmed.ncbi.nlm.nih.gov/30337689
https://pubmed.ncbi.nlm.nih.gov/30337689
DNA damage activates the ATM and ATR kinases that coordinate checkpoint and DNA repair pathways. An essential step in homology‐directed repair (HDR) of DNA breaks is the formation of RAD51 nucleofilaments mediated by PALB2–BRCA2; however, roles o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e456ed7c3250b0059f1989b51dfe545
https://europepmc.org/articles/PMC5341514/
https://europepmc.org/articles/PMC5341514/
Autor:
Marko J. Kallio, Pia Roos-Mattjus, Camilla Aspelin, Alexandra N. Elsing, Johanna K. Ahlskog, Johanna K. Björk, Lea Sistonen
Publikováno v:
Ahlskog, J K, Björk, J K, Elsing, A N, Aspelin, C, Kallio, M, Roos-Mattjus, P & Sistonen, L 2010, ' Anaphase-Promoting Complex/Cyclosome Participates in the Acute Response to Protein-Damaging Stress ', Molecular and Cellular Biology, vol. 30, no. 24, pp. 5608-5620 . https://doi.org/10.1128/MCB.01506-09
The ubiquitin E3 ligase anaphase-promoting complex/cyclosome (APC/C) drives degradation of cell cycle regulators in cycling cells by associating with the coactivators Cdc20 and Cdh1. Although a plethora of APC/C substrates have been identified, only
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::945686dc7cb90fe66913405f39027419
https://doi.org/10.1128/mcb.01506-09
https://doi.org/10.1128/mcb.01506-09
Publikováno v:
FEBS Journal. 276:7366-7374
Transcription factors are DNA-binding proteins that regulate key biological processes. Their interactions with DNA are commonly analyzed with gel-based electrophoretic mobility shift assay (EMSA) using radioactively labeled probes. Within various fie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b20d9524deeb4bce4cbd9d59164a315
https://doi.org/10.1111/j.1742-4658.2009.07446.x
https://doi.org/10.1111/j.1742-4658.2009.07446.x
Autor:
Andrey Mikhailov, Lila Pirkkala, Ville Hietakangas, Niko M. Sahlberg, Johanna K. Ahlskog, Carina I. Holmberg, Lea Sistonen, Jorma J. Palvimo, Maria Hellesuo, Annika M. Jakobsson
Publikováno v:
Molecular and Cellular Biology. 23:2953-2968
The heat shock response, which is accompanied by a rapid and robust upregulation of heat shock proteins (Hsps), is a highly conserved protection mechanism against protein-damaging stress. Hsp induction is mainly regulated at transcriptional level by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b849fc8e79955bcf0742dc69146184e
https://doi.org/10.1128/mcb.23.8.2953-2968.2003
https://doi.org/10.1128/mcb.23.8.2953-2968.2003