Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Johanna K, Ruohola"'
Publikováno v:
Growth Factors. 28:256-267
Expression of fibroblast growth factor 8 (FGF-8) is increased in several forms of hormonal cancer. It was previously shown to regulate expression of thrombospondin 1 (TSP-1), an inhibitor of angiogenesis, in S115 breast cancer cells. Here, we studied
VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumors
Autor:
Mirjami M. Mattila, Terhi Karpanen, Johanna K. Ruohola, Pirkko Härkönen, David A. Jackson, Kari Alitalo
Publikováno v:
International Journal of Cancer. 98:946-951
The spread of cancer cells to regional lymph nodes through the lymphatic system is the first step in the dissemination of breast cancer. In several human cancers including those of the breast and prostate, the expression of vascular endothelial growt
Autor:
Philippa D. Darbre, Pirkko Härkönen, Eeva M. Valve, Merja J. Tasanen, Johanna K. Ruohola, James F. Glover
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 78:389-400
The Shionogi 115 (S115) mouse mammary tumor cells express the MMTV-specific 1.7 kb mRNA (orf) at a high level in the presence of androgens. In lymphoid cells the orf-gene encodes a superantigen which has an important role in establishing self-toleran
FGF-8b increases angiogenic capacity and tumor growth of androgen-regulated S115 breast cancer cells
Autor:
Jani Seppänen, Merja J. Tasanen, Johanna K. Ruohola, Eeva M. Valve, Pirkko Härkönen, Mirjami M. Mattila
Publikováno v:
Oncogene. 20:2791-2804
Fibroblast growth factor 8 (FGF-8) is a secreted heparin-binding protein, which has transforming potential. Alternative splicing of the mouse Fgf-8 gene potentially codes for eight protein isoforms (a-h) which differ in their transforming capacity in
Publikováno v:
Biochemical and Biophysical Research Communications. 250:805-808
Fgf8 is an embryonally expressed mitogenic fibroblast growth factor which has transforming capacity. It is expressed in S115 mouse mammary tumor cells (S115 cells) and in parental tumors of DD/Sio mice as well as in some human breast and prostate can
Publikováno v:
Endocrinology. 136:2179-2188
We studied the androgen regulation of fibroblast growth factor (FGF) receptors (FGFRs) in the Shionogi 115 (S115) mouse mammary tumor cell line and its genetic variant Clone 22. In S115 cells, androgen maintains a transformed morphology, rate of prol
Autor:
Kati Tarkkonen, Johanna K. Ruohola, Jani Seppänen, Mirjami M. Mattila, Eeva M. Valve, Pirkko Härkönen
Publikováno v:
Molecular and cellular endocrinology. 253(1-2)
In the search for androgen target genes responsible for malignant growth in S115 mouse mammary tumor cells we found that thrombospondin 1 (TSP1) expression was strongly downregulated by testosterone (Te). Experiments with cycloheximide suggested that
VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumors
Autor:
Mirjami M-T, Mattila, Johanna K, Ruohola, Terhi, Karpanen, David G, Jackson, Kari, Alitalo, Pirkko L, Härkönen
Publikováno v:
International journal of cancer. 98(6)
The spread of cancer cells to regional lymph nodes through the lymphatic system is the first step in the dissemination of breast cancer. In several human cancers including those of the breast and prostate, the expression of vascular endothelial growt
Autor:
Pirkko Härkönen, Kari Alitalo, Eeva M. Valve, Marika J. Karkkainen, Johanna K. Ruohola, Vladimir Joukov
Publikováno v:
Molecular and cellular endocrinology. 149(1-2)
Vascular endothelial growth factor (VEGF) is a major inducer of tumor angiogenesis and an important prognostic factor in breast cancer. Hypoxia is an important inducer of VEGF expression but less is known of the role of hormones in VEGF regulation. W